Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Anna Vidal-Alabró"'
Autor:
Beatriz Fernández-Alarcón, Oscar Nolberger, Anna Vidal-Alabró, Raul Rigo-Bonnin, Josep M. Grinyó, Edoardo Melilli, Nuria Montero, Anna Manonelles, Ana Coloma, Alex Favà, Sergi Codina, Josep M. Cruzado, Helena Colom, Nuria Lloberas
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
AimsThe once-daily extended-release tacrolimus formulation (ER-Tac) has demonstrated similar efficacy and safety to the twice-daily immediate-release formulation (IR-Tac), but few population-based pharmacokinetic models have been developed in de novo
Externí odkaz:
https://doaj.org/article/e1e7a764787d4907916c5088a819c282
Autor:
Anna Vidal-Alabró, Helena Colom, Pere Fontova, Gema Cerezo, Edoardo Melilli, Nuria Montero, Ana Coloma, Anna Manonelles, Alex Favà, Josep M. Cruzado, Joan Torras, Josep M. Grinyó, Nuria Lloberas
Publikováno v:
Nefrología (English Edition), Vol 44, Iss 2, Pp 204-216 (2024)
Background and justification: The strategy of the concentration-dose (C/D) approach and the different profiles of tacrolimus (Tac) according to the cytochrome P450 polymorphisms (CYPs) focus on the metabolism of Tac and are proposed as tools for the
Externí odkaz:
https://doaj.org/article/080bb41af9964a478495db2667e29f1c
Autor:
Anna Vidal-Alabró, Helena Colom, Pere Fontova, Gema Cerezo, Edoardo Melilli, Núria Montero, Ana Coloma, Anna Manonellas, Alexandre Favà, Josep M. Cruzado, Joan Torras, Josep M. Grinyó, Núria Lloberas
Publikováno v:
Nefrología, Vol 44, Iss 2, Pp 204-216 (2024)
Resumen: Antecedentes y justificación: La estrategia de la aproximación concentración-dosis (C/D) y los distintos perfiles del tacrolimus (Tac), según los polimorfismos del citocromo P450 (CYPs) se centran en el metabolismo de Tac y se plantean c
Externí odkaz:
https://doaj.org/article/05d6c0eae98441bc9adb797370fdde68
Autor:
Laura Martinez Valenzuela, Anna Vidal-Alabró, Belén Rubio, Paula Antón-Pàmpols, Francisco Gómez-Preciado, Xavier Fulladosa, Josep Maria Cruzado, Juan Torras, Nuria Lloberas, Juliana Draibe
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6479 (2024)
The inflammasome regulates the innate inflammatory response and is involved in autoimmune diseases. In this study, we explored the levels of IL-18 and IL-1β in serum and urine and the influence of various single-nucleotide polymorphisms (SNPs) on ki
Externí odkaz:
https://doaj.org/article/4ffe262b651e4742add7d897f292a447
Autor:
Zeyar Mohammed Ali, Marinda Meertens, Beatriz Fernández, Pere Fontova, Anna Vidal-Alabró, Raul Rigo-Bonnin, Edoardo Melilli, Josep M. Cruzado, Josep M. Grinyó, Helena Colom, Nuria Lloberas
Publikováno v:
Pharmaceutics, Vol 15, Iss 12, p 2699 (2023)
The aim of the study is to develop a population pharmacokinetic (PopPK) model and to investigate the influence of CYP3A5/CYP3A4 and ABCB1 single nucleotide polymorphisms (SNPs) on the Tacrolimus PK parameters after LCP-Tac formulation in stable adult
Externí odkaz:
https://doaj.org/article/9d949f15b70a4ab1b8f23ab50ab7990f
Autor:
Pere Fontova, Lisanne N. van Merendonk, Anna Vidal-Alabró, Raül Rigo-Bonnin, Gema Cerezo, Stefaan van Oevelen, Oriol Bestard, Edoardo Melilli, Nuria Montero, Ana Coloma, Anna Manonelles, Joan Torras, Josep M. Cruzado, Josep M. Grinyó, Helena Colom, Nuria Lloberas
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1481 (2023)
Despite intensive monitoring of whole blood tacrolimus concentrations, acute rejection after kidney transplantation occurs during tacrolimus therapy. Intracellular tacrolimus concentrations could better reflect exposure at the site of action and its
Externí odkaz:
https://doaj.org/article/17151f14f7b844a0abfe1718be0a1db2
Autor:
Elena Crespo, Anna Vidal-Alabró, Thomas Jouve, Pere Fontova, Maik Stein, Sonila Mocka, Maria Meneghini, Anett Sefrin, Petra Hruba, Montserrat Gomà, Alba Torija, Laura Donadeu, Alex Favà, Josep M. Cruzado, Edoardo Melilli, Francesc Moreso, Ondrej Viklicky, Frederike Bemelman, Petra Reinke, Josep Grinyó, Nuria Lloberas, Oriol Bestard
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Achieving fast immunosuppression blood exposure after kidney transplantation is key to abrogating both preformed and de novo anti-donor humoral and cellular alloresponses. However, while tacrolimus (TAC) is the cornerstone immunosuppressant inhibitin
Externí odkaz:
https://doaj.org/article/e1f40afe8ab94a93a922e44c70f720c5
Autor:
Pere Fontova, Helena Colom, Raül Rigo-Bonnin, Lisanne N. van Merendonk, Anna Vidal-Alabró, Nuria Montero, Edoardo Melilli, Maria Meneghini, Anna Manonelles, Josep M. Cruzado, Juan Torras, Josep Maria Grinyó, Oriol Bestard, Nuria Lloberas
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Introduction: Tacrolimus is the backbone immunosuppressant after solid organ transplantation. Tacrolimus has a narrow therapeutic window with large intra- and inter-patient pharmacokinetic variability leading to frequent over- and under-immunosuppres
Externí odkaz:
https://doaj.org/article/919fc8842deb4744a8f2acf7f43d07ac
Autor:
Helga Simon-Molas, Xavier Vallvé-Martínez, Irene Caldera-Quevedo, Pere Fontova, Claudia Arnedo-Pac, Anna Vidal-Alabró, Esther Castaño, Àurea Navarro-Sabaté, Núria Lloberas, Ramon Bartrons, Anna Manzano
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7436 (2021)
The glycolytic modulator TP53-Inducible Glycolysis and Apoptosis Regulator (TIGAR) is overexpressed in several types of cancer and has a role in metabolic rewiring during tumor development. However, little is known about the role of this enzyme in pr
Externí odkaz:
https://doaj.org/article/3b16fe1e45cc44499c433f05c939aa88
Autor:
Anna Vidal-Alabró, Alícia G. Gómez-Valadés, Andrés Méndez-Lucas, Jordi Llorens, Ramon Bartrons, Jordi Bermúdez, Jose C. Perales
Publikováno v:
International Journal of Endocrinology, Vol 2011 (2011)
Recent reports point out the importance of the complex GK-GKRP in controlling glucose and lipid homeostasis. Several GK mutations affect GKRP binding, resulting in permanent activation of the enzyme. We hypothesize that hepatic overexpression of a mu
Externí odkaz:
https://doaj.org/article/c70250b757ab48f0bf0ce4e04dce12c4