Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Anna V. Roschke"'
Autor:
Anna V. Roschke, Oleg K. Glebov, Samir Lababidi, Kristen S. Gehlhaus, John N. Weinstein, Ilan R. Kirsch
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 11, Pp 1222-1230 (2008)
Chromosomal instability—a hallmark of epithelial cancers—is an ongoing process that results in aneuploidy and karyotypic heterogeneity of a cancer cell population. Previously, we stratified cancer cell lines in the NCI-60 drug discovery panel bas
Externí odkaz:
https://doaj.org/article/704a83da020d4d53be9d5910974efe7c
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 4, Iss 1, Pp 19-31 (2002)
Most human tumors and tumor cell lines exhibit numerical and structural chromosomal abnormalities. The goal of this study was to determine the ongoing rates of structural and numerical instability in selected cancer cell lines and to investigate the
Externí odkaz:
https://doaj.org/article/e169b470a8784c7cb079a9ab7bc25a82
Autor:
Ilan R. Kirsch, Kristen S. Gelhaus, Anna V. Roschke, David G. Covell, Ruili Huang, Anders Wallqvist
The karyotypic features of cancer cells have not been a particular focus of anticancer drug targeting either as guidance for treatment or as specific drug targets themselves. Cancer cell lines typically have considerable, characteristic, and variable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c08ce440fdf11ae49179cab924c170d
https://doi.org/10.1158/1535-7163.c.6531978.v1
https://doi.org/10.1158/1535-7163.c.6531978.v1
Autor:
Ilan R. Kirsch, Kristen S. Gelhaus, Anna V. Roschke, David G. Covell, Ruili Huang, Anders Wallqvist
Supplementary Tables A-M from Drugs aimed at targeting characteristic karyotypic phenotypes of cancer cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11cd08cdd5b45d8c2895569500fe4538
https://doi.org/10.1158/1535-7163.22485531
https://doi.org/10.1158/1535-7163.22485531
Autor:
W. M. Kuehl, Yan W. Asmann, Anna V. Roschke, Peter Leif Bergsagel, Yulia N. Demchenko, Wei Dong Chen
Publikováno v:
Nucleic Acids Research
Using a combination of array comparative genomic hybridization, mate pair and cloned sequences, and FISH analyses, we have identified in multiple myeloma cell lines and tumors a novel and recurrent type of genomic rearrangement, i.e. interchromosomal
Publikováno v:
Scientific Reports
Gross chromosomal rearrangements (GCRs), including translocations, inversions amplifications, and deletions, can be causal events leading to malignant transformation. GCRs are thought to be triggered by DNA double strand breaks (DSBs), which in turn
Autor:
Ana Gabrea, Gina Y. Kim, W. Michael Kuehl, Yulia N. Demchenko, Leif Bergsagel, Anna V. Roschke
Publikováno v:
Genes, Chromosomes and Cancer. 53:467-474
Primary IGH translocations involving seven recurrent partner loci and oncogenes are present in about 40% of multiple myeloma tumors. Secondary IGH rearrangements, which occur in a smaller fraction of tumors, usually are complex structures, including
Autor:
Paul S. Meltzer, Anna V. Roschke, Ilan R. Kirsch, Robert L. Walker, Yoonsoo Park, Ester Rozenblum, Geula Klorin, Frederic J. Kaye, Oleg K. Glebov
Publikováno v:
Cancer Genetics. 206:191-205
High-resolution oligonucleotide array comparative genomic hybridization (aCGH) and spectral karyotyping (SKY) were applied to a panel of malignant mesothelioma (MMt) cell lines. SKY has not been applied to MMt before, and complete karyotypes are repo
Autor:
Samir Lababidi, John N. Weinstein, Kristen Gehlhaus, Oleg K. Glebov, Anna V. Roschke, Ilan R. Kirsch
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 11, Pp 1222-1230 (2008)
Chromosomal instability—a hallmark of epithelial cancers—is an ongoing process that results in aneuploidy and karyotypic heterogeneity of a cancer cell population. Previously, we stratified cancer cell lines in the NCI-60 drug discovery panel bas
Autor:
W. Michael Kuehl, Ana Gabrea, Anna V. Roschke, Ying Qi, Jeffrey R. Sawyer, Bart Barlogie, Marialuisa Martelli, John D. Shaughnessy
Publikováno v:
Genes, Chromosomes and Cancer. 47:573-590
The pathogenesis of multiple myeloma (MM) is thought to involve at least two pathways, which generate hyperdiploid (HRD) or nonhyperdiploid (NHRD) tumors, respectively. Apart from chromosome content, the two pathways are distinguished by five primary