Low concentrations of medium-sized HDL particles predict incident CVD in chronic kidney disease patients

Autor: Baohai Shao, Farsad Afshinnia, Anna V. Mathew, Graziella E. Ronsein, Carissa Thornock, Angela D. Irwin, Mayank Kansal, Panduranga S. Rao, Mirela Dobre, Sadeer Al-Kindi, Matthew R. Weir, Alan Go, Jiang He, Jing Chen, Harold Feldman, Karin E. Bornfeldt, Subramaniam Pennathur, Matthias Kretzler, Debbie Gipson, Markus Bitzer, Crystal Gadegbeku, Keith Bellovich, Zeenat Bhat, Susan Massengill, Kalyani Perumal, Lawrence J. Appel, Debbie L. Cohen, James P. Lash, Robert G. Nelson, Mahboob Rahman, Vallabh O. Shah, Mark L. Unruh

Publikováno v: Journal of Lipid Research, Vol 64, Iss 6, Pp 100381- (2023)

Patients with chronic kidney disease (CKD) are at high risk for CVD. However, traditional CVD risk factors cannot completely explain the increased risk. Altered HDL proteome is linked with incident CVD in CKD patients, but it is unclear whether other

Externí odkaz: https://doaj.org/article/51bb7f209b9345f2821df3f6e9b94938

Altered HDL proteome predicts incident CVD in chronic kidney disease patients

Autor: Baohai Shao, Anna V. Mathew, Carissa Thornock, Subramaniam Pennathur, Matthias Kretzler, Debbie Gipson, Markus Bitzer, Crystal Gadegbeku, Keith Bellovich, Zeenat Bhat, Susan Massengill, Kalyani Perumal

Publikováno v: Journal of Lipid Research, Vol 62, Iss , Pp 100135- (2021)

Patients with chronic kidney disease (CKD) are at high risk for CVD. However, traditional lipid risk factors, including low HDL levels, cannot completely explain the increased risk. Altered HDL proteome is linked with both CVD and CKD, but the role o

Externí odkaz: https://doaj.org/article/b4aa4d551b3048118677416168a82eca

Salt-Responsive Metabolite, β-Hydroxybutyrate, Attenuates Hypertension

Autor: Saroj Chakraborty, Sarah Galla, Xi Cheng, Ji-Youn Yeo, Blair Mell, Vishal Singh, BengSan Yeoh, Piu Saha, Anna V. Mathew, Matam Vijay-Kumar, Bina Joe

Publikováno v: Cell Reports, Vol 25, Iss 3, Pp 677-689.e4 (2018)

Summary: Dietary salt reduction and exercise are lifestyle modifications for salt-sensitive hypertensives. While exercise has prominent metabolic effects, salt has an adverse effect on metabolic syndrome, of which hypertension is a hallmark. We hypot

Externí odkaz: https://doaj.org/article/becd80229958435d8c3a2344559f9d60

Critical Role for AMPK in Metabolic Disease-Induced Chronic Kidney Disease

Autor: Anne-Emilie Decleves, Florian Juszczak, Anna V. Mathew, Nathalie Caron

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 7994, p 7994 (2020)
JUSZCZAK, F, Caron, N, Mathew, A V & Declèves, A E 2020, ' Critical Role for AMPK in Metabolic Disease-Induced Chronic Kidney Disease ', International Journal of Molecular Sciences, vol. 21, no. 21, 7994, pp. 1-23 . https://doi.org/10.3390/ijms21217994

Chronic kidney disease (CKD) is prevalent in 9.1% of the global population and is a significant public health problem associated with increased morbidity and mortality. CKD is associated with highly prevalent physiological and metabolic disturbances

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052d4427e8801d6711691d8d370747e1
https://researchportal.unamur.be/en/publications/9ee7cbe2-a06e-4b8e-8577-0fa06879228e

Kynurenine pathway metabolites predict subclinical atherosclerotic disease and new cardiovascular events in chronic kidney disease

Autor: Trista Benitez, Elizabeth VanDerWoude, Yun Han, Jaeman Byun, Vetalise Cheofor Konje, Brenda W Gillespie, Rajiv Saran, Anna V Mathew

Publikováno v: Clinical kidney journal. 15(10)

Introduction Inflammation and oxidative stress contribute to the disproportionate burden of cardiovascular disease (CVD) in chronic kidney disease (CKD). Disordered catabolism of tryptophan via the kynurenine and indole pathways is linked to CVD in b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67aae2c94d22fdc3dce0483457ed01e5
https://pubmed.ncbi.nlm.nih.gov/36158159