Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Anna V, Molofsky"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Microglia remodel synapses and engulf apoptotic cells. The molecular program underlying these distinct functions are unclear. Here, the authors identify distinct microglial subsets associated with synaptic vs. neurogenic regions of the developing zeb
Externí odkaz:
https://doaj.org/article/827e8387a61f43bfa0b99a363397af48
Autor:
Julia A Kuhn, Ilia D Vainchtein, Joao Braz, Katherine Hamel, Mollie Bernstein, Veronica Craik, Madelene W Dahlgren, Jorge Ortiz-Carpena, Ari B Molofsky, Anna V Molofsky, Allan I Basbaum
Publikováno v:
eLife, Vol 10 (2021)
Peripheral nerve injury-induced neuropathic pain is a chronic and debilitating condition characterized by mechanical hypersensitivity. We previously identified microglial activation via release of colony-stimulating factor 1 (CSF1) from injured senso
Externí odkaz:
https://doaj.org/article/62a134c3d95e44b3af89fbe8fc850844
Autor:
Jerika J. Barron, Nicholas M. Mroz, Sunrae E. Taloma, Madelene W. Dahlgren, Jorge Ortiz-Carpena, Leah C. Dorman, Ilia D. Vainchtein, Caroline C. Escoubas, Ari B. Molofsky, Anna V. Molofsky
Publikováno v:
bioRxiv
The innate immune system plays essential roles in brain synaptic development, and immune dysregulation is implicated in neurodevelopmental diseases. Here we show that a subset of innate lymphocytes (group 2 innate lymphoid cells, ILC2s) is required f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::466609c5840600ffa1fa935483ea97bc
https://doi.org/10.1101/2023.03.16.532850
https://doi.org/10.1101/2023.03.16.532850
Autor:
Rafael T. Han, Ilia D. Vainchtein, Johannes C.M. Schlachetzki, Frances S. Cho, Leah C. Dorman, Eunji Ahn, Dong Kyu Kim, Jerika J. Barron, Hiromi Nakao-Inoue, Ari B. Molofsky, Christopher K. Glass, Jeanne T. Paz, Anna V. Molofsky
Publikováno v:
The Journal of experimental medicine, vol 220, iss 2
Microglia are critical regulators of brain development that engulf synaptic proteins during postnatal synapse remodeling. However, the mechanisms through which microglia sense the brain environment are not well defined. Here, we characterized the reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33bb84204fe9778ec512a95a323df0fe
https://doi.org/10.1084/jem.20220605
https://doi.org/10.1084/jem.20220605
Autor:
Aimee W. Kao, Austin L Wang, Anand Patwardhan, Michael Grabe, Phi T. Nguyen, Kean-Hooi Ang, Anna V. Molofsky, Carolina Alquezar, Michelle R. Arkin, Marcus Y. Chin, Mackenzie Welch
Publikováno v:
ACS Sensors
ACS sensors, vol 6, iss 6
ACS sensors, vol 6, iss 6
Lysosomes are important sites for macromolecular degradation, defined by an acidic lumenal pH of ∼4.5. To better understand lysosomal pH, we designed a novel, genetically encoded, fluorescent protein (FP)-based pH biosensor called Fluorescence Indi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2415b35c8d9c812672f8372fce4396ee
https://doi.org/10.1021/acssensors.0c02318
https://doi.org/10.1021/acssensors.0c02318
Autor:
Frances S. Cho, Ilia D. Vainchtein, Yuliya Voskobiynyk, Allison R. Morningstar, Francisco Aparicio, Bryan Higashikubo, Agnieszka Ciesielska, Diede W. M. Broekaart, Jasper J. Anink, Erwin A. van Vliet, Xinzhu Yu, Baljit S. Khakh, Eleonora Aronica, Anna V. Molofsky, Jeanne T. Paz
Publikováno v:
Cho, F S, Vainchtein, I D, Voskobiynyk, Y, Morningstar, A R, Aparicio, F, Higashikubo, B, Ciesielska, A, Broekaart, D W M, Anink, J J, van Vliet, E A, Yu, X, Khakh, B S, Aronica, E, Molofsky, A V & Paz, J T 2022, ' Enhancing GAT-3 in thalamic astrocytes promotes resilience to brain injury in rodents ', Science Translational Medicine, vol. 14, no. 652, eabj4310, pp. eabj4310 . https://doi.org/10.1126/scitranslmed.abj4310
Science translational medicine, vol 14, iss 652
Science translational medicine, 14(652):eabj4310. American Association for the Advancement of Science
Science Translational Medicine, 14(652):eabj4310. American Association for the Advancement of Science
Sci Transl Med
Science translational medicine, vol 14, iss 652
Science translational medicine, 14(652):eabj4310. American Association for the Advancement of Science
Science Translational Medicine, 14(652):eabj4310. American Association for the Advancement of Science
Sci Transl Med
Inflammatory processes induced by brain injury are important for recovery; however, when uncontrolled, inflammation can be deleterious, likely explaining why most anti-inflammatory treatments have failed to improve neurological outcomes after brain i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b054ff20f5d895b9821c2fb247c991a
https://pubmed.ncbi.nlm.nih.gov/35941196
https://pubmed.ncbi.nlm.nih.gov/35941196
Publikováno v:
Immunity. 54:211-224
Astrocytes play both physiological and pathological roles in maintaining central nervous system (CNS) function. Here, we review the varied functions of astrocytes and how these might change in subsets of reactive astrocytes. We review the current und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d80add1f61a53c3d6dd2947cda1ae29
https://doi.org/10.1016/j.immuni.2021.01.013
https://doi.org/10.1016/j.immuni.2021.01.013
Autor:
Leah C, Dorman, Phi T, Nguyen, Caroline C, Escoubas, Ilia D, Vainchtein, Yinghong, Xiao, Peter V, Lidsky, Haruna, Nakajo, Nicholas J, Silva, Christian, Lagares-Linares, Ellen Y, Wang, Sunrae E, Taloma, Beatriz, Cuevas, Hiromi, Nakao-Inoue, Brianna M, Rivera, Bjoern, Schwer, Carlo, Condello, Raul, Andino, Tomasz J, Nowakowski, Anna V, Molofsky
Publikováno v:
bioRxiv : the preprint server for biology.
Microglia, the innate immune cells of the brain, are exquisitely sensitive to dynamic changes in the neural environment. Using single cell RNA sequencing of the postnatal somatosensory cortex during topographic remapping, we identified a type I inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::77fff49b25e7b36499cbc1dc125ab87a
https://pubmed.ncbi.nlm.nih.gov/35233577
https://pubmed.ncbi.nlm.nih.gov/35233577
Autor:
Anna V. Molofsky, Mazen A. Kheirbek, Kelsey J Clausing, Mark M. Gergues, Ilia D. Vainchtein, Kasey J. Han, Brandon Brown, Victoria S. Turner, Hye Sun Choi
Publikováno v:
Nature neuroscience
Nature neuroscience, vol 23, iss 11
Nature neuroscience, vol 23, iss 11
The ventral hippocampus (vHPC) is a critical hub in networks that process emotional information. While recent studies have indicated that ventral CA1 (vCA1) projection neurons are functionally dissociable, the basic principles of how the inputs and o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08c6381828e0de5759d26ae89e123fc3
http://europepmc.org/articles/PMC7606799
http://europepmc.org/articles/PMC7606799
Autor:
Ilia D. Vainchtein, Anna V. Molofsky
Publikováno v:
Trends Neurosci
Trends in neurosciences, vol 43, iss 3
Trends in neurosciences, vol 43, iss 3
Healthy central nervous system (CNS) development and function require an intricate and balanced bidirectional communication between neurons and glia cells. In this review, we discuss the complementary roles of astrocytes and microglia in building the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9e77b6b780027c37587148342d65db
https://doi.org/10.1016/j.tins.2020.01.003
https://doi.org/10.1016/j.tins.2020.01.003