Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Anna V, Leopold"'
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Optical control over receptor tyrosine kinase (RTK) activity can find application in both basic biology and synthetic biology. Here the authors combine the photosensory module of DrBphP bacterial phytochrome with the Trk family of RTKs to obtain Trks
Externí odkaz:
https://doaj.org/article/d447bf17660142128b2c06f41c792119
Autor:
Anna V, Leopold, Stephen, Thankachan, Chun, Yang, Dmitry, Gerashchenko, Vladislav V, Verkhusha
Publikováno v:
Nature Methods. 19:871-880
Regulation of receptor tyrosine kinase (RTK) activity is necessary for studying cell signaling pathways in health and disease. We developed a generalized approach for engineering RTKs optically controlled with far-red light. We targeted the bacterial
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Understanding how neuronal activity patterns in the brain correlate with complex behavior is one of the primary goals of modern neuroscience. Chemical transmission is the major way of communication between neurons, however, traditional methods of det
Externí odkaz:
https://doaj.org/article/6774e016f19441b3b6e2fe30aa75de92
Publikováno v:
Chemical Science
Optogenetical and optochemical approaches can be used to control RTK signalling instead of growth factors, antibodies and small-molecule inhibitors.
Inhibition of receptor tyrosine kinases (RTKs) by small molecule inhibitors and monoclonal antib
Inhibition of receptor tyrosine kinases (RTKs) by small molecule inhibitors and monoclonal antib
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
Optical control over the activity of receptor tyrosine kinases (RTKs) provides an efficient way to reversibly and non-invasively map their functions. We combined catalytic domains of Trk (tropomyosin receptor kinase) family of RTKs, naturally activat
Publikováno v:
J Mol Biol
Optically controlled receptor tyrosine kinases (opto-RTKs) allow regulation of RTK signaling using light. Until recently, the majority of opto-RTKs were activated with blue-green light. Fusing a photosensory core module of Deinococcus radiodurans bac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37a3e7b332926e85ca06cdf58e15768d
https://europepmc.org/articles/PMC7306426/
https://europepmc.org/articles/PMC7306426/
Publikováno v:
Chemical Society Reviews. 47:2454-2484
Protein kinases are involved in the regulation of many cellular processes including cell differentiation, survival, migration, axon guidance and neuronal plasticity. A growing set of optogenetic tools, termed opto-kinases, allows activation and inhib