Selective mRNA degradation by antisense oligonucleotide-2,5A chimeras: Involvement of RNase H and RNase L

Autor: Anna Ubysz, Ian Robbins, Bernard Lebleu, Sylvie Vichier-Guerre, Robert W. Sobol, Guillaume Mitta, Bernard Rayner

Publikováno v: Biochimie
Biochimie, Elsevier, 1998, 80 (8-9), pp.711-20. ⟨10.1016/s0300-9084(99)80024-8⟩
Biochimie, Elsevier, 1998, 80 (8-9), pp.711-20

Antisense oligonucleotides (ON) allow the specific control of gene expression and phosphorothioate derivatives are currently being evaluated for possible clinical applications. Numerous second generation ON analogues with improved pharmacological pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a22f46c851a779bcc3e06af06d829a56
https://doi.org/10.1016/s0300-9084(99)80024-8