Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Anna Trauzold"'
Autor:
Anna-Christina Rambow, Insa Aschenbach, Sofie Hagelund, Doaa Tawfik, Jan-Paul Gundlach, Sebastian Weiße, Nicolai Maass, Anna Trauzold
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Binding of TRAIL to its death domain-containing receptors TRAIL-R1 and TRAIL-R2 can induce cell death and/or pro-inflammatory signaling. The importance of TRAIL and TRAIL-R1/R2 in tumor immune surveillance and cancer biology has meanwhile been well d
Externí odkaz:
https://doaj.org/article/df98f6fc26e5461cab7571c46261e202
Autor:
Anna Willms, Hella Schupp, Michelle Poelker, Alshaimaa Adawy, Jan Frederik Debus, Torsten Hartwig, Tim Krichel, Jürgen Fritsch, Steven Singh, Henning Walczak, Silvia von Karstedt, Heiner Schäfer, Anna Trauzold
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Abstract TNF-related apoptosis-inducing ligand (TRAIL) receptor 2 (TRAIL-R2) can induce apoptosis in cancer cells upon crosslinking by TRAIL. However, TRAIL-R2 is highly expressed by many cancers suggesting pro-tumor functions. Indeed, TRAIL/TRAIL-R2
Externí odkaz:
https://doaj.org/article/01faaca6a4584d9ebb8d543b9bdea437
Autor:
Sofie Hagelund, Anna Trauzold
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an important mediator of tumor immune surveillance. In addition, its potential to kill cancer cells without harming healthy cells led to the development of TRAIL receptor agonists, wh
Externí odkaz:
https://doaj.org/article/7943b2f2696546b3b966c533fa986c05
Autor:
Doaa Tawfik, Angela Zaccagnino, Alexander Bernt, Monika Szczepanowski, Wolfram Klapper, Albrecht Schwab, Holger Kalthoff, Anna Trauzold
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-17 (2020)
Abstract Background The human pancreatic cancer cell line A818–6 can be grown in vitro either as a highly malignant, undifferentiated monolayer (ML) or as three-dimensional (3D) single layer hollow spheres (HS) simulating a benign, highly different
Externí odkaz:
https://doaj.org/article/9b656db7e86545e5ae1471a8147f4dac
Autor:
Jan-Paul Gundlach, Charlotte Hauser, Franka Maria Schlegel, Christine Böger, Christian Röder, Christoph Röcken, Thomas Becker, Jan-Hendrik Egberts, Holger Kalthoff, Anna Trauzold
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-10 (2018)
Abstract Background The death receptors TRAIL-R1 and TRAIL-R2 are frequently overexpressed in cancer and there is an emerging evidence for their important role in malignant progression, also in the case of pancreatic ductal adenocarcinoma (PDAC). In
Externí odkaz:
https://doaj.org/article/fd93353d1fe04da2993bd5d883b6cc32
Autor:
Dorothee Winterberg, Lennart Lenk, Maren Oßwald, Fotini Vogiatzi, Carina Lynn Gehlert, Fabian-Simon Frielitz, Katja Klausz, Thies Rösner, Thomas Valerius, Anna Trauzold, Matthias Peipp, Christian Kellner, Denis Martin Schewe
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 12, p 2634 (2021)
B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most frequent malignancy in children and also occurs in adulthood. Despite high cure rates, BCP-ALL chemotherapy can be highly toxic. This type of toxicity can most likely be reduced by a
Externí odkaz:
https://doaj.org/article/c0f21f4ee6ba4856839802f5850fd12f
Autor:
Doaa Tawfik, Christopher Groth, Jan-Paul Gundlach, Matthias Peipp, Dieter Kabelitz, Thomas Becker, Hans-Heinrich Oberg, Anna Trauzold, Daniela Wesch
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Acquired immune evasion is one of the mechanisms that contributes to the dismal prognosis of cancer. Recently, we observed that different γδ T cell subsets as well as CD8+ αβ T cells infiltrate the pancreatic tissue. Interestingly, the abundance
Externí odkaz:
https://doaj.org/article/399e84bdb6fa467f9f93ff983e3eb50a
Autor:
Anna Willms, Hella Schittek, Sascha Rahn, Justyna Sosna, Ufuk Mert, Dieter Adam, Anna Trauzold
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0214847 (2019)
Due to their ability to preferentially induce cell death in tumor cells, while sparing healthy cells, TNF-related apoptosis-inducing ligand (TRAIL) and agonistic anti-TRAIL-R1 or anti-TRAIL-R2-specific antibodies are under clinical investigations for
Externí odkaz:
https://doaj.org/article/b399ac7566e0450e9157f35b7a9e1750
Autor:
Ufuk Mert, Alshaimaa Adawy, Elisabeth Scharff, Pierre Teichmann, Anna Willms, Verena Haselmann, Cynthia Colmorgen, Johannes Lemke, Silvia von Karstedt, Jürgen Fritsch, Anna Trauzold
Publikováno v:
Cancers, Vol 11, Iss 8, p 1167 (2019)
Binding of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to the plasma membrane TRAIL-R1/-R2 selectively kills tumor cells. This discovery led to evaluation of TRAIL-R1/-R2 as targets for anti-cancer therapy, yet the corresponding c
Externí odkaz:
https://doaj.org/article/71db7d2a031d4f8e937bcca8d1d4f662
Autor:
Lauritz Miarka, Charlotte Hauser, Ole Helm, Dörthe Holdhof, Silje Beckinger, Jan-Hendrik Egberts, Jan-Paul Gundlach, Lennart Lenk, Sascha Rahn, Wolfgang Mikulits, Anna Trauzold, Susanne Sebens
Publikováno v:
Cancers, Vol 11, Iss 6, p 745 (2019)
Most patients with pancreatic ductal adenocarcinoma (PDAC) undergoing curative resection relapse within months, often with liver metastases. The hepatic microenvironment determines induction and reversal of dormancy during metastasis. Both tumor grow
Externí odkaz:
https://doaj.org/article/564d32ffb5ac4c60882549465a30d014