Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Anna Tigerström"'
Autor:
Ola Fjellström, Sibel Akkaya, Hans-Georg Beisel, Per-Olof Eriksson, Karl Erixon, David Gustafsson, Ulrik Jurva, Daiwu Kang, David Karis, Wolfgang Knecht, Viveca Nerme, Ingemar Nilsson, Thomas Olsson, Alma Redzic, Robert Roth, Jenny Sandmark, Anna Tigerström, Linda Öster
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0113705 (2015)
Activated factor XI (FXIa) inhibitors are anticipated to combine anticoagulant and profibrinolytic effects with a low bleeding risk. This motivated a structure aided fragment based lead generation campaign to create novel FXIa inhibitor leads. A virt
Externí odkaz:
https://doaj.org/article/1a2cc35337574e84979292e3f9e6ec05
Autor:
Birgitta Karlsson Svalstedt, Anders Thelin, Annika Wellner, Johanna Vinblad, Margareta Herslöf, David Gustafsson, Yantao Chen, Cristian Bodin, Ola Fjellström, Stefan Blaho, Jenny Sandmark, Carina Johansson, Birgitta Rosengren, Sofia Martinsson, Tomas Fex, Jonas Boström, Andreas Moberg, Tomas Akerud, Emma Evertsson, Bingze Xu, Ryan Hicks, Magnus Althage, Emelie Jarkvist, Wolfgang Knecht, Per-Olof Eriksson, Marianne Ridderström, Ann-Margret Östlund-Lindqvist, Anna Tigerström, Anders Dahlén, Anne Legnehed, Thomas Antonsson, Alan Sabirsh, Inge Kalies, Fredrik Kartberg
Publikováno v:
J Biol Chem
Increased plasma concentrations of lipoprotein(a) (Lp(a)) are associated with an increased risk for cardiovascular disease. Lp(a) is composed of apolipoprotein(a) (apo(a)) covalently bound to apolipoprotein B of low-density lipoprotein (LDL). Many of
Point-of-care microvolume cytometer measures platelet counts with high accuracy from capillary blood
Autor:
Jose Miguel Sanchez, William M Dickerson, Jamie Cheng, Eugene Y Chan, Helena U. Westergren, Anna Tigerström, Jonathan Paraskos, Lillian Li, Anna Ekman, Rebecca Yu, Philipp Schatz
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 8, p e0256423 (2021)
PLoS ONE, Vol 16, Iss 8, p e0256423 (2021)
Background Point-of-care (PoC) testing of platelet count (PLT) provides real-time data for rapid decision making. The goal of this study is to evaluate the accuracy and precision of platelet counting using a new microvolume (8 μL), absolute counting
Autor:
Göran Dahl, Bernd Kappler, Anna Tigerström, Annette Brodte, Fredrik Edfeldt, Philip B. Rawlins, Anders Egnéus, Geoff Holdgate, Rutger H. A. Folmer, Gareth M. Davies, Stephan Steigele, Eva-Lotta Westberg, Stephan Heyse, Nichole O'Connell, Martin Ginkel, Per Hillertz, Alexander Mehrle
Publikováno v:
Slas Discovery
Surface plasmon resonance (SPR) is a powerful method for obtaining detailed molecular interaction parameters. Modern instrumentation with its increased throughput has enabled routine screening by SPR in hit-to-lead and lead optimization programs, and
Autor:
Glen Hughes, Simon Young, Ravita Kaur, Marita Olsson, Magdalena Rhedin, Rabia Hidi, Adam Platt, Tim Dwyer, Anna Tigerström
Publikováno v:
Monitoring Airway Disease.
Introduction: Increased blood eosinophils (EOS) are associated with increased exacerbations, disease severity and mortality in asthma, and therapeutic reduction of EOS is beneficial to these patients (J. Nixon Pharmacology & Therapeutics 2017). EDN i
Autor:
Magnus Althage, Mikael Levin, and Anna Tigerström, Roslyn M. Bill, Pontus Gourdon, Jan Rydström, Jenny Karlsson
Publikováno v:
Althage, M, Karlsson, J, Gourdon, P, Levin, M, Bill, R M, Tigerström, A & Rydström, J 2003, ' Functional split and crosslinking of the membrane domain of the beta subunit of proton-translocating transhydrogenase from Escherichia coli ', Biochemistry, vol. 42, no. 37, pp. 10998-1003 . https://doi.org/10.1021/bi034560x
Proton pumping nicotinamide nucleotide transhydrogenase from Escherichia coli contains an alpha subunit with the NAD(H)-binding domain I and a beta subunit with the NADP(H)-binding domain III. The membrane domain (domain II) harbors the proton channe
Autor:
Niek Dekker, Stefan Geschwindner, Patrik Johansson, Rob Horsefield, Clay W Scott, Anna Tigerström, Jeffrey S. Albert
Publikováno v:
Journal of medicinal chemistry. 56(8)
We describe the development of a novel fragment screening methodology employing a plate-based optical biosensor system that can operate in a 384-well format. The method is based on the “inhibition in solution assay” (ISA) approach using an immobi
Autor:
David Gustafsson, Ingemar Nilsson, Ola Fjellström, Per-Olof Eriksson, Karl Erixon, Wolfgang Knecht, Hans-Georg Beisel, Alma Redzic, Robert G. Roth, Jenny Sandmark, Daiwu Kang, Viveca Nerme, Linda Öster, David Karis, Ulrik Jurva, Tommy Olsson, Sibel Akkaya, Anna Tigerström
Publikováno v:
'PloS One ', vol: 10, pages: e0113705-1-e0113705-42 (2015)
PLoS ONE, Vol 10, Iss 1, p e0113705 (2015)
PLoS ONE
PLoS ONE, Vol 10, Iss 1, p e0113705 (2015)
PLoS ONE
Activated factor XI (FXIa) inhibitors are anticipated to combine anticoagulant and profibrinolytic effects with a low bleeding risk. This motivated a structure aided fragment based lead generation campaign to create novel FXIa inhibitor leads. A virt
Autor:
William M Dickerson, Rebecca Yu, Helena U Westergren, Jonathan Paraskos, Philipp Schatz, Anna Tigerstrom, Anna Ekman, José Sánchez, Jamie Cheng, Lillian Li, Eugene Y Chan
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0256423 (2021)
BackgroundPoint-of-care (PoC) testing of platelet count (PLT) provides real-time data for rapid decision making. The goal of this study is to evaluate the accuracy and precision of platelet counting using a new microvolume (8 μL), absolute counting,
Externí odkaz:
https://doaj.org/article/75e1cb5715034652b85e7af2b9e48fdd