Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Anna Tchenio"'
Autor:
Katia Monsorno, Kyllian Ginggen, Andranik Ivanov, An Buckinx, Arnaud L. Lalive, Anna Tchenio, Sam Benson, Marc Vendrell, Angelo D’Alessandro, Dieter Beule, Luc Pellerin, Manuel Mameli, Rosa Chiara Paolicelli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Microglia, the innate immune cells of the central nervous system, actively participate in brain development by supporting neuronal maturation and refining synaptic connections. These cells are emerging as highly metabolically flexible, able
Externí odkaz:
https://doaj.org/article/ca1e699ffea54efa99b93749b51797b1
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Early-life stress primes depression in adulthood. This study shows that early maternal separation leads to lateral habenula (LHb) hyperactivity and causes depressive-like phenotypes, the latter being reversible when LHb hyperactivity is reduced chemo
Externí odkaz:
https://doaj.org/article/936450413b8840da904071ec58df9446
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Depression is a highly heterogeneous disease characterized by symptoms spanning from anhedonia and behavioral despair to social withdrawal and learning deficit. Such diversity of behavioral phenotypes suggests that discrete neural circuits may underl
Externí odkaz:
https://doaj.org/article/b36f0e0ac0ea41a89784b7b461992664
Autor:
Salvatore Lecca, Frank Julius Meye, Massimo Trusel, Anna Tchenio, Julia Harris, Martin Karl Schwarz, Denis Burdakov, Francois Georges, Manuel Mameli
Publikováno v:
eLife, Vol 6 (2017)
A sudden aversive event produces escape behaviors, an innate response essential for survival in virtually all-animal species. Nuclei including the lateral habenula (LHb), the lateral hypothalamus (LH), and the midbrain are not only reciprocally conne
Externí odkaz:
https://doaj.org/article/44fb35704e394cbe98406303710d0a5a
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 8 (2016)
The lateral habenula (LHb) and the serotoninergic system both contribute to motivational states by encoding rewarding and aversive signals. Converging evidence suggests that perturbation of these systems is critical for the pathophysiology of mood di
Externí odkaz:
https://doaj.org/article/bb45f89b2ab6453e9c8ec3c3765ee8a9
Autor:
Jean-Baptiste Brault, Zengzhen Liu, Sabine Bardin, Delphine Ladarre, Vincent Fraisier, Anna Tchenio, Zsolt Lenkei, Jean Salamero, Cedric Delevoye, Bruno Goud, Stephanie Miserey
Alzheimer s disease (AD) is the most common form of dementia worldwide. One of AD s main pathological hallmarks is the cerebral plaque deposits of Beta-amyloid (ABeta). ABeta is generated through sequential enzymatic cleavage of the amyloid precursor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b13f2f33fd30d363a5b66bc21959da52
https://doi.org/10.1101/2023.04.05.535676
https://doi.org/10.1101/2023.04.05.535676
Autor:
Arnaud L. Lalive, Mauro Congiu, Christopher Lewis, Dominik Groos, Joseph A. Clerke, Anna Tchenio, Yuan Ge, Fritjof Helmchen, Manuel Mameli
Publikováno v:
Current biology : CB. 32(8)
The lateral habenula (LHb) supports learning processes enabling the prediction of upcoming rewards. While reward-related stimuli decrease the activity of LHb neurons, whether this anchors on synaptic inhibition to guide reward-driven behaviors remain
Publikováno v:
Neuropharmacology. 196
Excitatory synaptic transmission in the lateral habenula (LHb), an evolutionarily ancient subcortical structure, encodes aversive stimuli and affective states. Habenular glutamatergic synapses contribute to these processes partly through the activati
The nervous system can associate neutral cues with rewards to promote appetitive adaptive behaviors. The lateral habenula (LHb) contributes to such behaviors as rewards and reward-predictive cues inhibit this structure and engage LHb-to-dopamine circ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95801812b16a1e6e9048aed64dc50859
https://doi.org/10.1101/2021.01.21.427572
https://doi.org/10.1101/2021.01.21.427572