Výsledky vyhledávání - "Anna T. Rogojina"

Data from Vertical Inhibition of the RAF–MEK–ERK Cascade Induces Myogenic Differentiation, Apoptosis, and Tumor Regression in H/NRASQ61X Mutant Rhabdomyosarcoma

Autor: Angelina V. Vaseva, Peter J. Houghton, Kris C. Wood, Myron S. Ignatius, William D. Figg, Cody J. Peer, Sara M. Zimmerman, Anna T. Rogojina, Yidong Chen, Kunal Baxi, Long Wang, Terry J. Shackleford, Craig M. Goodwin, Marielle E. Yohe, Vanessa Del Pozo, Natalia Garcia

Oncogenic RAS signaling is an attractive target for fusion-negative rhabdomyosarcoma (FN-RMS). Our study validates the role of the ERK MAPK effector pathway in mediating RAS dependency in a panel of H/NRASQ61X mutant RMS cells and correlates in vivo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f8284cff2d8a98fdac0344310698ee
https://doi.org/10.1158/1535-7163.c.6543340

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Supplementary Methods from Vertical Inhibition of the RAF–MEK–ERK Cascade Induces Myogenic Differentiation, Apoptosis, and Tumor Regression in H/NRASQ61X Mutant Rhabdomyosarcoma

Supplementary Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23d3e61604c7ec0285e0bd4364f173cc
https://doi.org/10.1158/1535-7163.22522342

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Supplementary Figures from Vertical Inhibition of the RAF–MEK–ERK Cascade Induces Myogenic Differentiation, Apoptosis, and Tumor Regression in H/NRASQ61X Mutant Rhabdomyosarcoma

Supplementary figures and legends

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a5ff6f98e44014e486437be70565a6
https://doi.org/10.1158/1535-7163.22522345.v1

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Vertical Inhibition of the RAF–MEK–ERK Cascade Induces Myogenic Differentiation, Apoptosis, and Tumor Regression inH/NRASQ61XMutant Rhabdomyosarcoma

Autor: Sara Zimmerman, Terry J Shackleford, Yi Chen, Anna T Rogojina, Kris C. Wood, Angelina V. Vaseva, Cody J. Peer, William D. Figg, Kunal Baxi, Long Wang, Natalia Garcia, Myron S. Ignatius, Craig M. Goodwin, Vanessa Del Pozo, Peter J. Houghton, Marielle E. Yohe

Publikováno v: Molecular Cancer Therapeutics. 21:170-183

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::473927580cc24e9cdc412c6bd6a92d2f
https://doi.org/10.1158/1535-7163.mct-21-0194

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Vertical Inhibition of the RAF-MEK-ERK Cascade Induces Myogenic Differentiation, Apoptosis, and Tumor Regression in

Autor: Natalia, Garcia, Vanessa, Del Pozo, Marielle E, Yohe, Craig M, Goodwin, Terry J, Shackleford, Long, Wang, Kunal, Baxi, Yidong, Chen, Anna T, Rogojina, Sara M, Zimmerman, Cody J, Peer, William D, Figg, Myron S, Ignatius, Kris C, Wood, Peter J, Houghton, Angelina V, Vaseva

Publikováno v: Mol Cancer Ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eb8165807d213ed82a1bf0f5bee4290a
https://pubmed.ncbi.nlm.nih.gov/34737198

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Multiplex immunoassay analysis of biomarkers in clinically accessible quantities of human aqueous humor

Autor: Rajesh K, Sharma, Anna T, Rogojina, K V, Chalam

Publikováno v: Molecular Vision

Purpose Aqueous humor is intimately related to the cells of the anterior and posterior chambers, which affect its composition. Aqueous analysis provides useful information regarding physiological and pathophysiological processes in the eye. Human aqu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2cdf44024674d11e03386a80caab6251
https://pubmed.ncbi.nlm.nih.gov/19145248

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Isolation and characterization of mAMSA-hypersensitive mutants. Cytotoxicity of Top2 covalent complexes containing DNA single strand breaks

Autor: Anna T, Rogojina, John L, Nitiss

Publikováno v: The Journal of biological chemistry. 283(43)

Topoisomerase II (Top2) is the primary target for active anti-cancer agents. We developed an efficient approach for identifying hypersensitive Top2 mutants and isolated a panel of mutants in yeast Top2 conferring hypersensitivity to the intercalator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b1d932ded820ff1c7c346cc2a66c9ab
https://pubmed.ncbi.nlm.nih.gov/18723844

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Combined Targeting of β-Catenin and FLT-3 Is Synergistically Lethal Against Cultured and Primary AML Blast Progenitor Cells Expressing FLT3 Internal Tandem Duplication (ITD)

Autor: Saikat Saha, Christopher Leveque, Baohua Sun, Youli Zu, Santhana G. T. Devaraj, Anna T Rogojina, Sunil Sharma, Bhavin Shah, Swaminathan Padmanabhan Iyer, Warren Fiskus, Kapil N. Bhalla

Publikováno v: Blood. 124:618-618

β-catenin acts as a co-activator for the T-cell factor (TCF) 4/lymphoid enhancer factor (LEF) 1 bipartite transcription factor at the promoters of the WNT-β-catenin target genes, including cyclin D1, c-Myc and survivin. The canonical WNT-β-catenin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::111e1c366c4390eb32ff85ba00938445
https://doi.org/10.1182/blood.v124.21.618.618

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