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Acyltransferase-mediated selection of the length of the fatty acyl chain and of the acylation site governs activation of bacterial RTX toxins

Autor: Humaira Khaliq, Adriana Osickova, Radovan Fišer, Radim Osicka, Jana Holubova, Anna Sukova, Ondrej Stanek, Peter Sebo, Jiri Masin, David Jurnecka

Publikováno v: J Biol Chem

In a wide range of organisms, from bacteria to humans, numerous proteins have to be posttranslationally acylated to become biologically active. Bacterial r epeats in t o x in (RTX) cytolysins form a prominent group of proteins that are synthesized as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e3a3b613a1c36f1bf6a7d085427cc6
https://doi.org/10.1074/jbc.ra120.014122

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Residues 529 to 549 participate in membrane penetration and pore-forming activity of the Bordetella adenylate cyclase toxin

Autor: Adriana Osickova, Jiri Masin, Radovan Fišer, Peter Sebo, Anna Sukova, Gabriela Mikušová, Radim Osicka, Jana Roderova

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)

The adenylate cyclase toxin-hemolysin (CyaA, ACT or AC-Hly) of pathogenic Bordetellae delivers its adenylyl cyclase (AC) enzyme domain into the cytosol of host cells and catalyzes uncontrolled conversion of cellular ATP to cAMP. In parallel, the toxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5bd8ea8d27b3881d8848603c7f6d4b
http://europepmc.org/articles/PMC6453906

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Negative charge of the AC-to-Hly linking segment modulates calcium-dependent membrane activities of Bordetella adenylate cyclase toxin

Autor: Radovan Fišer, Jiri Masin, Vaclav Veverka, Jana Holubova, Ondrej Stanek, Josef Chmelík, Anna Sukova, Peter Sebo, Pavel Srb, Ladislav Bumba

Publikováno v: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1862:183310

Two distinct conformers of the adenylate cyclase toxin (CyaA) appear to accomplish its two parallel activities within target cell membrane. The translocating conformer would deliver the N-terminal adenylyl cyclase (AC) enzyme domain across plasma mem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b6c111d7d2e0db3a9a03086f057ded
https://doi.org/10.1016/j.bbamem.2020.183310

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