Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Anna Stieber"'
Autor:
Jennifer D. McBride, Bin Zhang, Kurt R. Brunden, Lakshmi Changolkar, Virginia M.-Y. Lee, Jeffrey J. Nirschl, Kevt’her Hoxha, John Q. Trojanowski, Hong Xu, Garrett S. Gibbons, Gerard D. Schellenberg, Mia O’Reilly, Soo-Jung Kim, Dawn M. Riddle, Anna Stieber
Publikováno v:
Acta Neuropathologica
The microtubule-associated protein tau (tau) forms hyperphosphorylated aggregates in the brains of tauopathy patients that can be pathologically and biochemically defined as distinct tau strains. Recent studies show that these tau strains exhibit str
Autor:
Yan Xu, Anna Stieber, Emily S. Meymand, Tagan Lehr, Bin Zhang, Edward B. Lee, John Q. Trojanowski, Sílvia Porta, Virginia M.-Y. Lee, Modupe F. Olufemi
Publikováno v:
Neuropathol Appl Neurobiol
Aim The heterogeneity in the distribution and morphological features of TAR DNA-binding protein-43 (TDP-43) pathology in the brains of frontotemporal lobar degeneration (FTLD-TDP) patients and their different clinical manifestations suggest that dist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd9992f4697115febcfac8be40df81e4
https://europepmc.org/articles/PMC8578586/
https://europepmc.org/articles/PMC8578586/
Autor:
Virginia M. Y. Lee, Anna Stieber, Modupe F. Olufemi, Bin Zhang, John Q. Trojanowski, Tagan Lehr, Sílvia Porta, Emily S. Meymand, Yan Xu, Edward B. Lee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08542d49acc69a863da2a9ac9371e928
https://doi.org/10.1111/nan.12732/v2/response1
https://doi.org/10.1111/nan.12732/v2/response1
Autor:
Mian Horvath, Bin Zhang, Angela Lo, Kelvin C. Luk, Tobias Raabe, Hannah J. Brown, Anna Stieber, Yuling Liang, Anna Caputo
Publikováno v:
eNeuro
Alpha-synuclein (aSyn) participates in synaptic vesicle trafficking and synaptic transmission, but its misfolding is also strongly implicated in Parkinson’s disease (PD) and other neurodegenerative disorders known as synucleinopathies where misfold
Autor:
Sarah A Weitzman, Dawn M. Riddle, Zhiyong Li, Lakshmi Changolkar, Erik D. Roberson, Anna Stieber, Bin Zhang, Alexandra Kats, Sneha Narasimhan, John Q. Trojanowski, Virginia M.-Y. Lee
Publikováno v:
Journal of Experimental Medicine. 217
Tauopathies are characterized by abnormal accumulation of tau protein in neurons and glia. In Alzheimer’s disease (AD), tau aggregates in neurons, while in corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP), tau also aggregate
Autor:
Virginia M.-Y. Lee, Modupe F. Olufemi, Anna Stieber, John Q. Trojanowski, Bin Zhang, Rose M. Pitkin, Chao Peng, Kelvin C. Luk, Dustin J. Covell, John L. Robinson, Ronald J. Gathagan, Coraima Medellin
Publikováno v:
Nature
In Lewy body diseases-including Parkinson's disease, without or with dementia, dementia with Lewy bodies, and Alzheimer's disease with Lewy body co-pathology 1 -α-synuclein (α-Syn) aggregates in neurons as Lewy bodies and Lewy neurites 2 . By contr
Autor:
Zhuohao He, Kurt R. Brunden, Ted Abel, Jennifer D. McBride, Sneha Narasimhan, Magdalena Nitla, Lakshmi Changolkar, Jing L. Guo, Ronald J. Gathagan, John Q. Trojanowski, Hyesung Kim, Virginia M.-Y. Lee, Douglas A. Coulter, Anna Stieber, Cuiyong Yue, Bin Zhang, Christopher G. Dengler
Publikováno v:
Nature Medicine. 24:29-38
Alzheimer’s disease (AD) is characterized by extracellular amyloid-β (Aβ) plaques and intracellular tau inclusions. However, the exact mechanistic link between these two AD lesions remains enigmatic. Through injection of human AD-brain-derived pa
Autor:
Luisa Victoria Silva, Lakshmi Changolkar, Zhuohao He, Jing L. Guo, Jennifer D. McBride, Anna Stieber, Virginia M.-Y. Lee, Bin Zhang, Sneha Narasimhan, Ronald J. Gathagan, John Q. Trojanowski
Publikováno v:
The Journal of Neuroscience. 37:11406-11423
Pathological tau aggregates occur in Alzheimer's disease (AD) and other neurodegenerative tauopathies. It is not clearly understood why tauopathies vary greatly in the neuroanatomical and histopathological patterns of tau aggregation, which contribut
Autor:
Jennifer D. McBride, Virginia M.-Y. Lee, Ronald J. Gathagan, Anna Stieber, Sneha Narasimhan, John Q. Trojanowski, Bin Zhang, Zhuohao He, Lakshmi Changolkar, Jing L. Guo, Michiyo Iba
Publikováno v:
The Journal of Experimental Medicine
Intracerebral inoculation of tau fibrils from AD brains results in the induction and propagation of tau inclusions in WT mice.
Filamentous tau aggregates are hallmark lesions in numerous neurodegenerative diseases, including Alzheimer’s diseas
Filamentous tau aggregates are hallmark lesions in numerous neurodegenerative diseases, including Alzheimer’s diseas
Autor:
Linda K. Kwong, Anna Stieber, Krista Spiller, Clark R. Restrepo, Virginia M.-Y. Lee, Claudia Cheung, John Q. Trojanowski
Publikováno v:
Journal of Neuroscience. 36:7707-7717
Motor neurons (MNs) are the neuronal class that is principally affected in amyotrophic lateral sclerosis (ALS), but it is widely known that individual motor pools do not succumb to degeneration simultaneously. Because >90% of ALS patients have an acc