Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Anna Starr,"'
Autor:
Anna Starr,
Publikováno v:
Hatfield Graduate Journal of Public Affairs, Vol 6, Iss 1 (2022)
Problems persist throughout the U.S. healthcare system including exorbitant costs, poor health scores, high rates of uninsured, and lack of access to services among marginalized groups. Among many proposed solutions is a constitutional provision to h
Externí odkaz:
https://doaj.org/article/ae284dde89df4fca96cd440da720c3d3
Autor:
Pratish Thakore, James E. Clark, Aisah A. Aubdool, Dibesh Thapa, Anna Starr, Paul A. Fraser, Keith Farrell-Dillon, Elizabeth S. Fernandes, Ian McFadzean, Susan D. Brain
Publikováno v:
Biomolecules, Vol 14, Iss 4, p 442 (2024)
TRPC5 is a non-selective cation channel that is expressed in cardiomyocytes, but there is a lack of knowledge of its (patho)physiological role in vivo. Here, we examine the role of TRPC5 on cardiac function under basal conditions and during cardiac h
Externí odkaz:
https://doaj.org/article/8e0bbe9f106945c5825424a3000f4ab8
Autor:
Jade D. Bailey, Marina Diotallevi, Thomas Nicol, Eileen McNeill, Andrew Shaw, Surawee Chuaiphichai, Ashley Hale, Anna Starr, Manasi Nandi, Elena Stylianou, Helen McShane, Simon Davis, Roman Fischer, Benedikt M. Kessler, James McCullagh, Keith M. Channon, Mark J. Crabtree
Publikováno v:
Cell Reports, Vol 28, Iss 1, Pp 218-230.e7 (2019)
Summary: Classical activation of macrophages (M(LPS+IFNγ)) elicits the expression of inducible nitric oxide synthase (iNOS), generating large amounts of NO and inhibiting mitochondrial respiration. Upregulation of glycolysis and a disrupted tricarbo
Externí odkaz:
https://doaj.org/article/cc2fff285c5a45c9a7e1583fa7e6da7b
Publikováno v:
F1000Research, Vol 4 (2015)
Sepsis is a systemic inflammatory response triggered by microbial infection that can cause cardiovascular collapse, insufficient tissue perfusion and multi-organ failure. The cation channel transient receptor potential vanilloid 4 (TRPV4) is expresse
Externí odkaz:
https://doaj.org/article/63298b149ea84d7d8571a7da508805a8
Autor:
Anna Starr, Christoph Thiemermann, Olena Rudyk, Claire A. Sand, Catherine D. E. Wilder, David F. Treacher, Domenico Spina, Manasi Nandi
Publikováno v:
Journal of Applied Physiology
Sepsis and sepsis-associated multiorgan failure represent the major cause of mortality in intensive care units worldwide. Cardiovascular dysfunction, a key component of sepsis pathogenesis, has received much research interest, although research trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13987274be786fa0c7a98e8e71243b54
https://doi.org/10.1152/japplphysiol.00793.2014
https://doi.org/10.1152/japplphysiol.00793.2014
Autor:
Lamia, Heikal, Anna, Starr, Dania, Hussein, Jesus, Prieto-Lloret, Phil, Aaronson, Lea Ann, Dailey, Manasi, Nandi
Publikováno v:
JACC. Basic to Translational Science
Visual Abstract
Highlights • Tetrahydrobiopterin is an essential cofactor for NO production. • Limitation of endogenous tetrahydrobiopterin reduces NO bioavailability, enhances oxidative stress, and impairs vascular function. • Orally supp
Highlights • Tetrahydrobiopterin is an essential cofactor for NO production. • Limitation of endogenous tetrahydrobiopterin reduces NO bioavailability, enhances oxidative stress, and impairs vascular function. • Orally supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::166376ef4af2c73ef541c9bd95b774dd
https://pubmed.ncbi.nlm.nih.gov/29963647
https://pubmed.ncbi.nlm.nih.gov/29963647
Publikováno v:
Journal of Molecular Neuroscience. 34:149-155
The release of neuropeptides from primary sensory nerve fibers has been implicated in the modulation of local immune responses in surface tissues, such as the skin and the gastrointestinal mucosa, thereby inducing neurogenic inflammation, which is ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fcad75554fbf44dff81bfa474c49325
https://doi.org/10.1007/s12031-007-9015-9
https://doi.org/10.1007/s12031-007-9015-9
Publikováno v:
Arthritis & Rheumatism. 52:3248-3256
Objective To investigate the endogenous involvement of transient receptor potential vanilloid 1 (TRPV1) in a model of knee joint inflammation in the mouse. Methods Following characterization of wild-type (WT) and TRPV1-knockout mice, inflammation was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e248b67971754784341359052dd42d
https://doi.org/10.1002/art.21297
https://doi.org/10.1002/art.21297
Publikováno v:
Starr, A, Hussein, D & Nandi, M 2013, ' The regulation of vascular tetrahydrobiopterin bioavailability ', VASCULAR PHARMACOLOGY, vol. 58, no. 3, pp. 219-230 . https://doi.org/10.1016/j.vph.2012.08.002
6R l-erythro-5,6,7,8-tetrahydrobiopterin (BH4) is an essential cofactor for several enzymes including phenylalanine hydroxylase and the nitric oxide synthases (NOS). Oral supplementation of BH4 has been successfully employed to treat subsets of patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db2efefff481cf05cd434ac7b1cc41df
https://pubmed.ncbi.nlm.nih.gov/23634439
https://pubmed.ncbi.nlm.nih.gov/23634439
Autor:
Philip Cunningham, Zhen Wang, Anna Starr, Raymond Stidwill, Yue Ma, Belen Torondel, Manasi Nandi, James Leiper, Peter D. Kelly
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 32(11)
Objective— The overproduction of vascular NO contributes toward the circulatory collapse observed in patients with septic shock. Dimethylarginine dimethylaminohydrolase (DDAH), which has 2 isoforms, metabolizes asymmetrically methylated arginines (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f841a7522d929b5004ebd1e6778dbd
https://pubmed.ncbi.nlm.nih.gov/22995517
https://pubmed.ncbi.nlm.nih.gov/22995517