Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Anna Siskova"'
Autor:
Michal Kroupa, Ondrej Kubecek, Kristyna Tomasova, Petr Hanak, Marketa Krupova, Klara Cervena, Anna Siskova, Jachym Rosendorf, Petr Hosek, Ludmila Vodickova, Pavel Vodicka, Vaclav Liska, Stanislav John, Veronika Vymetalkova, Jiri Petera
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Telomeric sequences, the structures comprised of hexanucleotide repeats and associated proteins, play a pivotal role in chromosome end protection and preservation of genomic stability. Herein we address telomere length (TL) dynamics in prima
Externí odkaz:
https://doaj.org/article/e208be7268cb49858512e83c538d6774
Autor:
Josef Horak, Ondrej Kubecek, Anna Siskova, Katerina Honkova, Irena Chvojkova, Marketa Krupova, Monika Manethova, Sona Vodenkova, Sandra García-Mulero, Stanislav John, Filip Cecka, Ludmila Vodickova, Jiri Petera, Stanislav Filip, Veronika Vymetalkova
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Despite distant metastases being the critical factor affecting patients’ survival, they remain poorly understood. Our study thus aimed to molecularly characterize colorectal cancer liver metastases (CRCLMs) and explore whether molecular profiles di
Externí odkaz:
https://doaj.org/article/e8f2282a449d4e539c6f4ba856f3ae77
Autor:
Jiri Jungwirth, Marketa Urbanova, Arnoud Boot, Petr Hosek, Petra Bendova, Anna Siskova, Jiri Svec, Milan Kment, Daniela Tumova, Sandra Summerova, Zdenek Benes, Tomas Buchler, Pavel Kohout, Tomas Hucl, Radoslav Matej, Ludmila Vodickova, Tom van Wezel, Pavel Vodicka, Veronika Vymetalkova
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/661b0738232849dc90dff74cfcc6baac
Autor:
Anna Siskova, Jan Kral, Jana Drabova, Klara Cervena, Kristyna Tomasova, Jiri Jungwirth, Tomas Hucl, Pavel Kohout, Sandra Summerova, Ludmila Vodickova, Pavel Vodicka, Veronika Vymetalkova
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7656 (2022)
A colorectal adenoma, an aberrantly growing tissue, arises from the intestinal epithelium and is considered as precursor of colorectal cancer (CRC). In this study, we investigated structural and numerical chromosomal aberrations in adenomas, hypothes
Externí odkaz:
https://doaj.org/article/a97334baf4464dfbb236a8044b2d290e
Autor:
Miriam J. Kavec, Marketa Urbanova, Pavol Makovicky, Alena Opattová, Kristyna Tomasova, Michal Kroupa, Klara Kostovcikova, Anna Siskova, Nazila Navvabi, Michaela Schneiderova, Veronika Vymetalkova, Ludmila Vodickova, Pavel Vodicka
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 10, p 5704 (2022)
Oxidative stress, oxidative DNA damage and resulting mutations play a role in colorectal carcinogenesis. Impaired equilibrium between DNA damage formation, antioxidant status, and DNA repair capacity is responsible for the accumulation of genetic mut
Externí odkaz:
https://doaj.org/article/df5a938844314a999f3a9b6f54b5dd40
Publikováno v:
Cells, Vol 9, Iss 6, p 1540 (2020)
Colorectal carcinogenesis (CRC) is caused by the gradual long-term accumulation of both genetic and epigenetic changes. Recently, epigenetic alterations have been included in the classification of the CRC molecular subtype, and this points out their
Externí odkaz:
https://doaj.org/article/835696b660ea417caed42524bc4ed80e
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 9, p 3260 (2020)
Colorectal cancer (CRC) is a malignant disease with an incidence of over 1.8 million new cases per year worldwide. CRC outcome is closely related to the respective stage of CRC and is more favorable at less advanced stages. Detection of early colorec
Externí odkaz:
https://doaj.org/article/c81a9d9aded24e6c87cf3276d42fcbde
Autor:
Pavel Vodicka, Marketa Urbanova, Pavol Makovicky, Kristyna Tomasova, Michal Kroupa, Rudolf Stetina, Alena Opattova, Klara Kostovcikova, Anna Siskova, Michaela Schneiderova, Veronika Vymetalkova, Ludmila Vodickova
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2473 (2020)
Oxidative stress with subsequent premutagenic oxidative DNA damage has been implicated in colorectal carcinogenesis. The repair of oxidative DNA damage is initiated by lesion-specific DNA glycosylases (hOGG1, NTH1, MUTYH). The direct evidence of the
Externí odkaz:
https://doaj.org/article/975e3a4273b44b248fc1687c4e478c17
Autor:
Anna Siskova, Veronika Vymetalkova, Pavel Vodicka, Giulio Ferrero, Alessio Naccarati, Chuanpit Hampel, Regine Schneider-Stock
Publikováno v:
Cancer Research. 82:3368-3368
A colorectal adenoma, an aberrantly growing tissue that arises from the intestinal epithelium is considered a precursor of colorectal cancer, the third most common cancer worldwide. In the presented study, we performed a whole transcriptome analysis
Autor:
Kristyna Tomasova, Michal Kroupa, Anna Siskova, Josef Horak, Ondrej Vycital, Vaclav Liska, Ludmila Vodickova, Pavel Vodicka
Publikováno v:
Cancer Research. 82:2316-2316
Telomere attrition is a well-known hallmark of malignancy in cancer tissue. Our study analyzed the relative telomere length in adenomas, precursor lesions of colorectal adenocarcinoma. We investigated if the accelerated telomere length shortening occ