Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Anna Siniscalchi"'
Background Donation of returned medicines is a debated health policy issue as it is discouraged by WHO, but accepted in some countries. Methods Lessons learned from a donation programme of returned medicines carried out in Europe were documented. Res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a158d8dab1fe8c4c8e64bf741211459
http://hdl.handle.net/11392/2415348
http://hdl.handle.net/11392/2415348
Publikováno v:
Neurochemistry International. 63:112-120
Primary cortical neurons exposed to the mitochondrial toxin NaN3 (0.1-3 mM) were submitted to oxidative stress with H2O2 (30-150 μM), to mimic conditions observed in neurodegenerative disorders. The effects of such treatment on a series of parameter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae16fe4f3a5b2ddf16a6139215836ab
https://doi.org/10.1016/j.neuint.2013.05.005
https://doi.org/10.1016/j.neuint.2013.05.005
Autor:
Rita, Selvatici, Selvatici, Rita, Anna, Siniscalchi, Siniscalchi, Anna, Susanna, Spisani, Spisani, Susanna
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 13:553-564
Recently, interest in small peptide molecules as potential drug candidates has revived. In this review, two series of synthetic peptides and their selective effects on the inflammatory response have been described, focusing on the intracellular pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56034681a22a982ebbfb9a61c67221f
https://doi.org/10.2174/1389557511313040008
https://doi.org/10.2174/1389557511313040008
Autor:
Cristiano Nazzaro, Mario Barbieri, Lorenzo Beani, Katia Varani, Anna Siniscalchi, Rita J. Valentino
Publikováno v:
Neuropharmacology. 58:457-464
The effects of nociceptin/orphanin FQ on putative serotonin (5HT) neurons of the dorsal raphe nucleus (DRN), known to modulate the behavioral responses to stress, were investigated in vivo and in vitro. In DRN slices from unstressed rats, nociceptin/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84eab3766137025578bf9a9677f22552
https://doi.org/10.1016/j.neuropharm.2009.09.004
https://doi.org/10.1016/j.neuropharm.2009.09.004
Autor:
Remo Guerrini, Susanna Spisani, Sofia Falzarano, Adriano Mollica, Anna Siniscalchi, Rita Selvatici, Lara Franceschetti
Publikováno v:
FEBS Journal. 275:449-457
Elucidation of the involvement of protein kinase C subtypes in several diseases is an important challenge for the future development of new drug targets. We previously identified the PKI55 protein, which acts as a protein kinase C modulator, establis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::264c0fdbeb03fed93a1f95de102e52b4
https://doi.org/10.1111/j.1742-4658.2007.06212.x
https://doi.org/10.1111/j.1742-4658.2007.06212.x
Publikováno v:
Archives of Biochemistry and Biophysics. 462:74-82
PKI55 protein, coded by the recently identified KI55 gene [R. Selvatici, E. Melloni, M. Ferrati, C. Piubello, F.C. Marincola, E. Gandini, J. Mol. Evol. 57 (2003) 131-139] is synthesized following protein kinase C (PKC) activation and acts as a PKC mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8882ba6406a4f96ecaa85cdb0ad93f
https://doi.org/10.1016/j.abb.2007.03.018
https://doi.org/10.1016/j.abb.2007.03.018
Publikováno v:
NeuroToxicology. 28:622-629
An intracellular calcium ([Ca(2+)](i)) increase is involved in sodium azide (NaN(3))-induced neurotoxicity, an in vitro model of brain ischemia. In this study the questions of possible additional sources of calcium influx, besides glutamate receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0982703970fe3ec445c81eeba12105eb
https://doi.org/10.1016/j.neuro.2007.01.005
https://doi.org/10.1016/j.neuro.2007.01.005
Autor:
Sofia Falzarano, Silvia Marino, Sabrina Cavallini, Lara Franceschetti, Rita Selvatici, Anna Siniscalchi
Publikováno v:
Neurochemistry International. 49:729-736
The aim of the current study was to characterize the effects of chemical ischemia and reperfusion at the transductional level in the brain. Protein kinase C isoforms (alpha, beta(1), beta(2), gamma, delta and epsilon) total levels and their distribut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ee48982d7b931d84abde2f98d564904
https://doi.org/10.1016/j.neuint.2006.06.003
https://doi.org/10.1016/j.neuint.2006.06.003
Autor:
Matteo Marti, Anna Siniscalchi, Lorenzo Beani, Sabrina Cavallini, Rita Selvatici, Clementina Bianchi, Silvia Marino
Publikováno v:
Neurochemistry International. 47:482-490
Superfused rat cerebral cortex slices were submitted to a continuous electrical (5 Hz) stimulation and treated with sodium azide (1–10 mM) in the presence of 2 mM 2-deoxyglucose (“chemical ischemia”). Presynaptic cholinergic activity, evaluated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdb703c26bde0f807e5bd3612bf5b91c
https://doi.org/10.1016/j.neuint.2005.06.003
https://doi.org/10.1016/j.neuint.2005.06.003
Autor:
Carmela Piubello, Rita Selvatici, Luca Marani, Clementina Bianchi, Silvia Marino, Anna Siniscalchi
Publikováno v:
Neurochemistry International. 46:117-125
Glutamate-induced changes in the subcellular distribution of protein kinase C isoforms and in the intracellular calcium concentration were investigated in rat primary cortical neurons. Western blot analysis of protein kinase C isoforms (α, β 1 , β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c82864e98be026035b7595962019e70d
https://doi.org/10.1016/j.neuint.2004.08.001
https://doi.org/10.1016/j.neuint.2004.08.001