Zobrazeno 1 - 10 of 31 pro vyhledávání: '"Anna Senik"'
1
Akademický článek
DRAM triggers lysosomal membrane permeabilization and cell death in CD4(+) T cells infected with HIV.
Autor: Mireille Laforge, Sophie Limou, Francis Harper, Nicoletta Casartelli, Vasco Rodrigues, Ricardo Silvestre, Houda Haloui, Jean-Francois Zagury, Anna Senik, Jerome Estaquier
Publikováno v: PLoS Pathogens, Vol 9, Iss 5, p e1003328 (2013)
Productive HIV infection of CD4(+) T cells leads to a caspase-independent cell death pathway associated with lysosomal membrane permeabilization (LMP) and cathepsin release, resulting in mitochondrial outer membrane permeabilization (MOMP). Herein, w
Externí odkaz: https://doaj.org/article/39011285a3494ce4b268c0db487fd53a
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2
The anti-caspase inhibitor Q-VD-OPH prevents AIDS disease progression in SIV-infected rhesus macaques
Autor: Guido Silvestri, Julie Garibal, Vasco Rodrigues, Alain Pruvost, Shahul Mouhamad, Mireille Laforge, Valérie Monceaux, Jérôme Estaquier, Anna Senik, Bruno Hurtrel, Henintsoa Rabezanahary, Ricardo Silvestre, Anabela Cordeiro-da-Silva, Laure Campillo-Gimenez, Marie-Christine Cumont
Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 2018, 128 (4), pp.1627-1640. ⟨10.1172/JCI95127⟩
Apoptosis has been proposed as a key mechanism responsible for CD4+ T cell depletion and immune dysfunction during HIV infection. We demonstrated that Q-VD-OPH, a caspase inhibitor, inhibits spontaneous and activation-induced death of T cells from SI
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a722532b12bdd83ff678a61fe5e8c8
https://europepmc.org/articles/PMC5873886/
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3
Commitment to Apoptosis in CD4 + T Lymphocytes Productively Infected with Human Immunodeficiency Virus Type 1 Is Initiated by Lysosomal Membrane Permeabilization, Itself Induced by the Isolated Expression of the Viral Protein Nef
Autor: Jérôme Estaquier, Anna Senik, Mireille Laforge, Frédéric Petit
Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2007, 81 (20), pp.11426-11440. ⟨10.1128/JVI.00597-07⟩
Primary CD4 + T lymphocytes, supporting in vitro human immunodeficiency virus type 1 (HIV-1) replication, are destined to die by apoptosis. We explored the initial molecular events that act upstream from mitochondrial dysfunction in CD4 + T lymphocyt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c750995bd6850f6f6f7c5db46628189e
https://doi.org/10.1128/jvi.00597-07
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5
Elektronická kniha
L'histoire mouvementée de la reconnaissance officielle des crimes de Vichy contre les Juifs : Autour de la cérémonie de commémoration de la rafle du Vel' d'Hiv
Autor: Anna Senik
Jusqu'en 1992 les crimes de l'État français de Vichy contre les Juifs n'avaient jamais fait l'objet d'une reconnaissance officielle. Ce silence fut brisé quand le Comité Vel'd'Hiv'42 lança un appel au président Mitterrand, lui demandant de proc
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6
[Untitled]
Autor: Nicolas Bidère, Anna Senik
Publikováno v: APOPTOSIS. 6:371-375
Cell death by apoptosis is involved in the maintenance of T cell receptor diversity, self tolerance, and T-cell number homeostasis. Until recently, apoptosis was thought to require caspase activation. Evidence is now accumulating that a caspase-indep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd97dbc4a2e7b47b9d734296d937b00e
https://doi.org/10.1023/a:1011390103783
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7
Antibody-mediated endocytosis of G250 tumor-associated antigen allows targeted gene transfer to human renal cell carcinoma in vitro
Autor: R Hirsch, Dominique Thierry, Matthieu Rouleau, Eric Angevin, A Gorter, G Chavanel, François Hirsch, Antoine Durrbach, Alain Chapel, Pascal Poncet, Anna Senik, Bernard Charpentier
Publikováno v: Scopus-Elsevier
Specific gene transfer into targeted tumor cells remains a critical issue for the development of systemic gene therapy protocols. With this end in view, we have tested the possibility of selectively directing genes to tumor cells through the recognit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f8241928a6a130576e2d7131090cb5
https://doi.org/10.1038/sj.cgt.7700085
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9
Apoptotic death concurrent with CD3 stimulation in primary human CD8+ T lymphocytes: a role for endogenous granzyme B
Autor: Anna Senik, Sylvie Carmona, Nicolas Bidère, Aurore Devocelle, Bernard Charpentier, Mireille Laforge
Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2006, 176 (7), pp.3966-3977. ⟨10.4049/jimmunol.176.7.3966⟩
We exposed primary CD8+ T cells to soluble CD3 mAb plus IL-2 and limited numbers of monocytes (3%). These cells were activated but concurrently subjected to ongoing apoptosis (∼25% were apoptotic from day 2 of culture). However, their costimulated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7823e7b9b90689ba769574cd86de4296
https://pubmed.ncbi.nlm.nih.gov/16547231
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