Výsledky vyhledávání - "Anna Schildbach"

Synthesis of lipid-linked oligosaccharides by a compartmentalized multi-enzyme cascade for the in vitro N-glycosylation of peptides

Autor: Erdmann Rapp, Valerian Grote, Simon Boecker, Marcus Hoffmann, Udo Reichl, Robert Kottler, Katja Bettenbrock, Anna Schildbach, Markus Pietzsch, Sebastian Tischlik, Christin Bergmann, Thomas Rexer, Reza Mahour, Lisa Wenzel

Publikováno v: Journal of Biotechnology. 322:54-65

A wide range of glycoproteins can be recombinantly expressed in aglycosylated forms in bacterial and cell-free production systems. To investigate the effect of glycosylation of these proteins on receptor binding, stability, efficacy as drugs, pharmac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c7298e72819d695f384f2f30860c41
https://doi.org/10.1016/j.jbiotec.2020.07.003

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One pot synthesis of GDP-mannose by a multi-enzyme cascade for enzymatic assembly of lipid-linked oligosaccharides

Autor: Anna Schildbach, Markus Pietzsch, Udo Reichl, Angelika Schierhorn, Erdmann Rapp, Jan Klapproth, Reza Mahour, Thomas Rexer

Publikováno v: Biotechnology and Bioengineering

Glycosylation of proteins is a key function of the biosynthetic‐secretory pathway in the endoplasmic reticulum (ER) and Golgi apparatus. Glycosylated proteins play a crucial role in cell trafficking and signaling, cell‐cell adhesion, blood‐grou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4882cb9a86f7f833978ed6bb5fd14a8d
https://doi.org/10.1002/bit.26454

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Establishment of a five-enzyme cell-free cascade for the synthesis of uridine diphosphate N-acetylglucosamine

Autor: Anna Schildbach, Thomas Rexer, Markus Pietzsch, Jan Klapproth, Erdmann Rapp, Reza Mahour, Udo Reichl, Steffen Klamt

Publikováno v: Journal of Biotechnology

In spite of huge endeavors in cell line engineering to produce glycoproteins with desired and uniform glycoforms, it is still not possible in vivo. Alternatively, in vitro glycoengineering can be used for the modification of glycans. However, in vitr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffbe3cb8a176ba20ed300ead6d2df6cb
https://hdl.handle.net/21.11116/0000-0005-54E8-721.11116/0000-0001-F434-1

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