Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Anna Salerno-Kochan"'
Autor:
Patrik Polák, William Garland, Om Rathore, Manfred Schmid, Anna Salerno-Kochan, Lis Jakobsen, Maria Gockert, Piotr Gerlach, Toomas Silla, Jens S. Andersen, Elena Conti, Torben Heick Jensen
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113325- (2023)
Summary: The RNA exosome is a versatile ribonuclease. In the nucleoplasm of mammalian cells, it is assisted by its adaptors the nuclear exosome targeting (NEXT) complex and the poly(A) exosome targeting (PAXT) connection. Via its association with the
Externí odkaz:
https://doaj.org/article/011a771c02a44db48dc70d320227324d
Autor:
Marija Kojic, Tomasz Gawda, Monika Gaik, Alexander Begg, Anna Salerno-Kochan, Nyoman D. Kurniawan, Alun Jones, Katarzyna Drożdżyk, Anna Kościelniak, Andrzej Chramiec-Głąbik, Soroor Hediyeh-Zadeh, Maria Kasherman, Woo Jun Shim, Enakshi Sinniah, Laura A. Genovesi, Rannvá K. Abrahamsen, Christina D. Fenger, Camilla G. Madsen, Julie S. Cohen, Ali Fatemi, Zornitza Stark, Sebastian Lunke, Joy Lee, Jonas K. Hansen, Martin F. Boxill, Boris Keren, Isabelle Marey, Margarita S. Saenz, Kathleen Brown, Suzanne A. Alexander, Sergey Mureev, Alina Batzilla, Melissa J. Davis, Michael Piper, Mikael Bodén, Thomas H. J. Burne, Nathan J. Palpant, Rikke S. Møller, Sebastian Glatt, Brandon J. Wainwright
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Subunits of the Elongator complex have been implicated in several nervous system pathologies. Here, the authors identify ELP2 variants in six patients with neurodevelopmental anomalies and show in mouse models that these variants impact protein stabi
Externí odkaz:
https://doaj.org/article/04bbd860a4c34da0ae14a920e50e23e1
Autor:
Marija Kojic, Monika Gaik, Bence Kiska, Anna Salerno-Kochan, Sarah Hunt, Angelo Tedoldi, Sergey Mureev, Alun Jones, Belinda Whittle, Laura A. Genovesi, Christelle Adolphe, Darren L. Brown, Jennifer L. Stow, Kirill Alexandrov, Pankaj Sah, Sebastian Glatt, Brandon J. Wainwright
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Elp6 is a component of the Elongator complex that regulates tRNAs and translation. Here the authors identify a mutation in the Elp6 gene that contributes to the cerebellar ataxia-like phenotype in a mutant mouse.
Externí odkaz:
https://doaj.org/article/abbd7a3dce6a4cee904088b04300ff36
Autor:
Nyoman D. Kurniawan, Margarita Saenz, Melissa J. Davis, Anna Salerno-Kochan, Julie S. Cohen, Sebastian Glatt, Anna Kościelniak, Ali Fatemi, Mikael Bodén, Martin F. Boxill, Joy Lee, Woo Jun Shim, Nathan J. Palpant, Tomasz Gawda, Jonas K. Hansen, Katarzyna Drożdżyk, Alexander Begg, Rikke S. Møller, Michael Piper, Marija Kojic, Soroor Hediyeh-Zadeh, Thomas H. J. Burne, Brandon J. Wainwright, Kathleen Brown, Isabelle Marey, Sergey Mureev, Rannvá K. Abrahamsen, Enakshi Sinniah, Zornitza Stark, Laura A. Genovesi, Monika Gaik, Andrzej Chramiec-Głąbik, Suzanne Alexander, Alun Jones, Alina Batzilla, Christina Fenger, Camilla Gøbel Madsen, Maria Kasherman, Boris Keren, Sebastian Lunke
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Kojic, M, Gawda, T, Gaik, M, Begg, A, Salerno-Kochan, A, Kurniawan, N D, Jones, A, Drożdżyk, K, Kościelniak, A, Chramiec-Głąbik, A, Hediyeh-Zadeh, S, Kasherman, M, Shim, W J, Sinniah, E, Genovesi, L A, Abrahamsen, R K, Fenger, C D, Madsen, C G, Cohen, J S, Fatemi, A, Stark, Z, Lunke, S, Lee, J, Hansen, J K, Boxill, M F, Keren, B, Marey, I, Saenz, M S, Brown, K, Alexander, S A, Mureev, S, Batzilla, A, Davis, M J, Piper, M, Bodén, M, Burne, T H J, Palpant, N J, Møller, R S, Glatt, S & Wainwright, B J 2021, ' Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype ', Nature Communications, vol. 12, 2678 . https://doi.org/10.1038/s41467-021-22888-5
Kojic, M, Gawda, T, Gaik, M, Begg, A, Salerno-Kochan, A, Kurniawan, N D, Jones, A, Drożdżyk, K, Kościelniak, A, Chramiec-Głąbik, A, Hediyeh-Zadeh, S, Kasherman, M, Shim, W J, Sinniah, E, Genovesi, L A, Abrahamsen, R K, Fenger, C D, Madsen, C G, Cohen, J S, Fatemi, A, Stark, Z, Lunke, S, Lee, J, Hansen, J K, Boxill, M F, Keren, B, Marey, I, Saenz, M S, Brown, K, Alexander, S A, Mureev, S, Batzilla, A, Davis, M J, Piper, M, Bodén, M, Burne, T H J, Palpant, N J, Møller, R S, Glatt, S & Wainwright, B J 2021, ' Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype ', Nature Communications, vol. 12, 2678 . https://doi.org/10.1038/s41467-021-22888-5
Intellectual disability (ID) and autism spectrum disorder (ASD) are the most common neurodevelopmental disorders and are characterized by substantial impairment in intellectual and adaptive functioning, with their genetic and molecular basis remainin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e88d1f07cbf7c539d80a6e3ae160ebc4
https://doaj.org/article/04bbd860a4c34da0ae14a920e50e23e1
https://doaj.org/article/04bbd860a4c34da0ae14a920e50e23e1
Autor:
Anna Salerno-Kochan, Andreas Horn, Pritha Ghosh, Chandran Nithin, Anna Kościelniak, Andreas Meindl, Daniela Strauss, Rościsław Krutyhołowa, Oliver Rossbach, Janusz M Bujnicki, Monika Gaik, Jan Medenbach, Sebastian Glatt
The TRIM-NHL protein Meiotic P26 (Mei-P26) acts as a regulator of cell fate in Drosophila. Its activity is critical for ovarian germline stem cell maintenance, differentiation of oocytes, and spermatogenesis. Mei-P26 functions as a post-transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34791bf60636beccc0571d2a7202c512
Autor:
Oliver Rossbach, Daniela Strauss, Sebastian Glatt, Anna Kościelniak, Monika Gaik, Andreas Horn, Janusz M. Bujnicki, Pritha Ghosh, Anna Salerno-Kochan, Jan Medenbach, Chandran Nithin
The TRIM-NHL protein Meiotic P26 (Mei-P26) acts as a regulator of cell fate in Drosophila. Its activity is critical for ovarian germline stem cell maintenance, differentiation of oocytes and spermatogenesis. Mei-P26 functions as a post-transcriptiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8597d1068ce36dba761d0e2d9f3e9d3e
https://doi.org/10.1101/2021.09.20.461029
https://doi.org/10.1101/2021.09.20.461029
Autor:
Piotr Gerlach, William Garland, Mahesh Lingaraju, Anna Salerno-Kochan, Fabien Bonneau, Jérôme Basquin, Torben Heick Jensen, Elena Conti
Publikováno v:
Gerlach, P, Garland, W, Lingaraju, M, Salerno-Kochan, A, Bonneau, F, Basquin, J, Jensen, T H & Conti, E 2022, ' Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome ', Molecular Cell, vol. 82, no. 13, pp. 2505-2518.e7 . https://doi.org/10.1016/j.molcel.2022.04.011
Molecular Cell
Molecular Cell
In mammalian cells, spurious transcription results in a vast repertoire of unproductive non-coding RNAs, whose deleterious accumulation is prevented by rapid decay. The nuclear exosome targeting (NEXT) complex plays a central role in directing non-fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b7a76c083e03805b5e0babc6a45b7c
https://doi.org/10.1016/j.molcel.2022.04.011
https://doi.org/10.1016/j.molcel.2022.04.011
Autor:
Anna Salerno-Kochan, Bence Kiska, Kirill Alexandrov, Belinda Whittle, Christelle Adolphe, Marija Kojic, Sergey Mureev, Alun Jones, Laura A. Genovesi, Sarah Hunt, Angelo Tedoldi, Pankaj Sah, Monika Gaik, Brandon J. Wainwright, Darren L. Brown, Sebastian Glatt, Jennifer L. Stow
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Nature Communications
Cerebellar ataxias are severe neurodegenerative disorders with an early onset and progressive and inexorable course of the disease. Here, we report a single point mutation in the gene encoding Elongator complex subunit 6 causing Purkinje neuron degen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a66cbb71c9d401f89db9392564d374d
http://link.springer.com/article/10.1038/s41467-018-05765-6
http://link.springer.com/article/10.1038/s41467-018-05765-6
Autor:
Marta Dziedzicka-Wasylewska, Dariusz Zurawek, Piotr Popik, Anna Salerno-Kochan, Agnieszka Nikiforuk, Tomasz Kos
Publikováno v:
Schizophrenia research. 192
It has been shown that the metabotropic glutamate receptor subtype 5 (mGluR5) is functionally associated with the NMDA subtype of the glutamate receptor family (NMDA receptors). These two receptors colocalize in brain regions associated with schizoph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf21240d8d87a96b0e07cbbd83dc04cd
https://pubmed.ncbi.nlm.nih.gov/28433499
https://pubmed.ncbi.nlm.nih.gov/28433499