Chlorpromazine, a Clinically Approved Drug, Inhibits SARS-CoV-2 Nucleocapsid-Mediated Induction of IL-6 in Human Monocytes

Autor: Iwona Karwaciak, Kaja Karaś, Anna Sałkowska, Joanna Pastwińska, Marcin Ratajewski

Publikováno v: Molecules, Vol 27, Iss 12, p 3651 (2022)

The COVID-19 pandemic, caused by the rapidly spreading SARS-CoV-2 virus, led to the unprecedented mobilization of scientists, resulting in the rapid development of vaccines and potential pharmaceuticals. Although COVID-19 symptoms are moderately seve

Externí odkaz: https://doaj.org/article/7e4846b5f3cf4a90a2e705d5c3b22aeb

Nucleocapsid and Spike Proteins of the Coronavirus SARS-CoV-2 Induce IL6 in Monocytes and Macrophages—Potential Implications for Cytokine Storm Syndrome

Autor: Iwona Karwaciak, Anna Sałkowska, Kaja Karaś, Jarosław Dastych, Marcin Ratajewski

Publikováno v: Vaccines, Vol 9, Iss 1, p 54 (2021)

The pandemic of the new coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) has led to the deaths of more than 1.5 million people worldwide. SARS-CoV-2 causes COVID-19, which exhibits wide variation in the course of disease in di

Externí odkaz: https://doaj.org/article/913690c72d0d46bb9ac8c3af33c9bc2b

Identification of Novel Molecular Markers of Human Th17 Cells

Autor: Anna Sałkowska, Kaja Karaś, Iwona Karwaciak, Aurelia Walczak-Drzewiecka, Mariusz Krawczyk, Marta Sobalska-Kwapis, Jarosław Dastych, Marcin Ratajewski

Publikováno v: Cells, Vol 9, Iss 7, p 1611 (2020)

Th17 cells are important players in host defense against pathogens such as Staphylococcus aureus, Candida albicans, and Bacillus anthracis. Th17 cell-mediated inflammation, under certain conditions in which balance in the immune system is disrupted,

Externí odkaz: https://doaj.org/article/e09d1790a6b74007b8bf006b889269c5

SARS-CoV-2 Proteins Induce IFNG in Th1 Lymphocytes Generated from CD4+ Cells from Healthy, Unexposed Polish Donors

Autor: Kaja Karaś, Anna Sałkowska, Jarosław Dastych, Marcin Ratajewski, Iwona Karwaciak

Publikováno v: Vaccines
Vaccines, Vol 8, Iss 673, p 673 (2020)

The outbreak of the SARS-CoV-2 virus in December 2019 has caused the deaths of several hundred thousand people worldwide. Currently, the pathogenesis of COVID-19 is poorly understood. During the course of COVID-19 infection, many patients experience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a197870022d2c5b5ac46a72b61721379
http://europepmc.org/articles/PMC7712722

Identification of Corosolic and Oleanolic Acids as Molecules Antagonizing the Human RORγT Nuclear Receptor Using the Calculated Fingerprints of the Molecular Similarity

Autor: Joanna Pastwińska, Kaja Karaś, Anna Sałkowska, Iwona Karwaciak, Katarzyna Chałaśkiewicz, Błażej A. Wojtczak, Rafał A. Bachorz, Marcin Ratajewski

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 1906, p 1906 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1906

RORγT is a protein product of the RORC gene belonging to the nuclear receptor subfamily of retinoic-acid-receptor-related orphan receptors (RORs). RORγT is preferentially expressed in Th17 lymphocytes and drives their differentiation from naive CD4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::416c449f441023475abd5f22201eb520
https://doi.org/10.3390/ijms23031906