Zobrazeno 1 - 10
of 197
pro vyhledávání: '"Anna S. Gukovskaya"'
Autor:
Olga A. Mareninova, Dustin L. Dillon, Carli J.M. Wightman, Iskandar Yakubov, Toshimasa Takahashi, Herbert Y. Gaisano, Keith Munson, Masaki Ohmuraya, David Dawson, Ilya Gukovsky, Anna S. Gukovskaya
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 599-622 (2022)
Background: Autophagosome, the central organelle in autophagy process, can assemble via canonical pathway mediated by LC3-II, the lipidated form of autophagy-related protein LC3/ATG8, or noncanonical pathway mediated by the small GTPase Rab9. Canonic
Externí odkaz:
https://doaj.org/article/11feff5cad444a05b90bf2cb94aaf905
Autor:
Olga A. Mareninova, Matthias Sendler, Sudarshan Ravi Malla, Iskandar Yakubov, Samuel W. French, Elmira Tokhtaeva, Olga Vagin, Viola Oorschot, Renate Lüllmann-Rauch, Judith Blanz, David Dawson, Judith Klumperman, Markus M. Lerch, Julia Mayerle, Ilya Gukovsky, Anna S. Gukovskaya
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 1, Iss 6, Pp 678-694 (2015)
Background & Aims: The pathogenic mechanism of pancreatitis is poorly understood. Recent evidence implicates defective autophagy in pancreatitis responses; however, the pathways mediating impaired autophagy in pancreas remain largely unknown. Here, w
Externí odkaz:
https://doaj.org/article/cb4a33f8eeb6420680ed96b3e0cadf95
Autor:
Viktória Venglovecz, Savio G. Barreto, Aurelia Lugea, Stephen J. Pandol, Péter Hegyi, Anna S. Gukovskaya, Robert Sutton, Aida Habtezion, Dhiraj Yadav, Christie Y. Jeon
Publikováno v:
Gut
Acute pancreatitis (AP), an acute inflammatory disorder of the exocrine pancreas, is one of the most common gastrointestinal diseases encountered in emergency departments with no specific treatments. Laboratory-based research has formed the cornersto
Autor:
Eszter T. Vegh, Natalia Shalbueva, Zoltán Rakonczay, Dustin L. Dillon, Nicholas O. Davidson, Stephen J. Pandol, Anna S. Gukovskaya, Olga A. Mareninova, David W. Dawson, Sudarshan R. Malla, Steven J. Bensinger, Carli J. Wightman, Toshimasa Takahashi, Yan Xie, Herbert Y. Gaisano, Samuel W. French, Fred S. Gorelick, Ilya Gukovsky
Publikováno v:
J Clin Invest
The Journal of clinical investigation, vol 131, iss 15
The Journal of clinical investigation, vol 131, iss 15
Disordered lysosomal/autophagy pathways initiate and drive pancreatitis, but the underlying mechanisms and links to disease pathology are poorly understood. Here, we show that the mannose-6-phosphate (M6P) pathway of hydrolase delivery to lysosomes c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51296d66f09bb85e129d2fbc9e461ec8
https://europepmc.org/articles/PMC8321573/
https://europepmc.org/articles/PMC8321573/
Autor:
Anna S. Gukovskaya, Sudarshan R. Malla, Ujjwal M. Mahajan, Thomas Wartmann, Walter Halangk, F. Ulrich Weiss, Markus M. Lerch, Fred S. Gorelick, Matthias Sendler, Julia Mayerle, Franziska Gisela Thiel, Ali A. Aghdassi, Thomas Reinheckel, Carina De Boni, Burkhard Krueger
Publikováno v:
Cell Mol Life Sci
Premature intrapancreatic trypsinogen activation is widely regarded as an initiating event for acute pancreatitis. Previous studies have alternatively implicated secretory vesicles, endosomes, lysosomes, or autophagosomes/autophagolysosomes as the pr
Publikováno v:
Gastroenterology. 156:1941-1950
Acute pancreatitis is an inflammatory disorder of the exocrine pancreas associated with tissue injury and necrosis. The disease can be mild, involving only the pancreas, and resolve spontaneously within days or severe, with systemic inflammatory resp
Autor:
Keith Munson, Toshimasa Takahashi, Anna S. Gukovskaya, Iskandar Yakubov, Carli J. Wightman, Ilya Gukovsky, Olga A. Mareninova, Dustin L. Dillon, David W. Dawson, Herbert Y. Gaisano, Masaki Ohmuraya
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 599-622 (2022)
Cellular and molecular gastroenterology and hepatology, vol 13, iss 2
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 599-622 (2022)
Cellular and molecular gastroenterology and hepatology, vol 13, iss 2
Background Autophagosome, the central organelle in autophagy process, can assemble via canonical pathway mediated by LC3-II, the lipidated form of autophagy-related protein LC3/ATG8, or noncanonical pathway mediated by the small GTPase Rab9. Canonica
Autor:
Dustin L. Dillon, Anna S. Gukovskaya, Sophie Gretler, Guy E. Groblewski, Ilya Gukovsky, Wenzhuo Jia, Conner L. Holthaus, Olga A. Mareninova, Michael Pimienta, Diana D. H. Thomas
Publikováno v:
Autophagy
Pancreatitis is a common, sometimes fatal, disease of exocrine pancreas, initiated by damaged acinar cells. Recent studies implicate disordered macroautophagy/autophagy in pancreatitis pathogenesis. ATG8/LC3 protein is critical for autophagosome form
Publikováno v:
Gastroenterology. 153:1212-1226
Pancreatitis is a common disorder with significant morbidity and mortality, yet little is known about its pathogenesis, and there is no specific or effective treatment. Its development involves dysregulated autophagy and unresolved inflammation, demo