Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Anna Roujeinikova"'
Autor:
Alexandra Tikhomirova, Emmylee R. McNabb, Luca Petterlin, Georgia L. Bellamy, Kyaw H. Lin, Christopher A. Santoso, Ella S. Daye, Fatimah M. Alhaddad, Kah Peng Lee, Anna Roujeinikova
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-20 (2024)
Abstract Campylobacter jejuni is a very common cause of gastroenteritis, and is frequently transmitted to humans through contaminated food products or water. Importantly, C. jejuni infections have a range of short- and long-term sequelae such as irri
Externí odkaz:
https://doaj.org/article/25ab43b35c454493a85517ac2e1abf2d
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
Externí odkaz:
https://doaj.org/article/611900622540491d9aab1d22dd8b4971
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT The flagellar motor protein FliL is conserved across many microbes, but its exact role has been obscured by varying fliL mutant phenotypes. We reanalyzed results from fliL studies and found they utilized alleles that differed in the amount o
Externí odkaz:
https://doaj.org/article/7d92007001d14a49828768a09315a913
Autor:
Mohammad M. Rahman, Alexandra Tikhomirova, Joyanta K. Modak, Melanie L. Hutton, Claudiu T. Supuran, Anna Roujeinikova
Publikováno v:
Gut Pathogens, Vol 12, Iss 1, Pp 1-7 (2020)
Abstract With the rise of bacterial resistance to conventional antibiotics, re-purposing of Food and Drug Administration (FDA) approved drugs currently used to treat non-bacteria related diseases as new leads for antibacterial drug discovery has beco
Externí odkaz:
https://doaj.org/article/f7789a24a4624956acb4bbf49a1e26c0
Autor:
Joyanta K. Modak, Alexandra Tikhomirova, Rebecca J. Gorrell, Mohammad M. Rahman, Despina Kotsanas, Tony M. Korman, Jose Garcia-Bustos, Terry Kwok, Richard L. Ferrero, Claudiu T. Supuran, Anna Roujeinikova
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1660-1667 (2019)
Ethoxzolamide (EZA), acetazolamide, and methazolamide are clinically used sulphonamide drugs designed to treat non-bacteria-related illnesses (e.g. glaucoma), but they also show antimicrobial activity against the gastric pathogen Helicobacter pylori.
Externí odkaz:
https://doaj.org/article/eb44d51be2b54acb9cc99fb86c5f74d4
Autor:
Xiaotian Zhou, Anna Roujeinikova
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
In the bacterial flagellar motor, the cell-wall-anchored stator uses an electrochemical gradient across the cytoplasmic membrane to generate a turning force that is applied to the rotor connected to the flagellar filament. Existing theoretical concep
Externí odkaz:
https://doaj.org/article/6cea49c658e44a38a98572caa824d0df
Autor:
Mayra A. Machuca, Kevin S. Johnson, Yu C. Liu, David L. Steer, Karen M. Ottemann, Anna Roujeinikova
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract It is recently appreciated that many bacterial chemoreceptors have ligand-binding domains (LBD) of the dCACHE family, a structure with two PAS-like subdomains, one membrane-proximal and the other membrane-distal. Previous studies had implica
Externí odkaz:
https://doaj.org/article/70d3bd8e624444ddaa9c81528f895161
Autor:
Mohammad F. Khan, Mayra A. Machuca, Mohammad M. Rahman, Cengiz Koç, Raymond S. Norton, Brian J. Smith, Anna Roujeinikova
Publikováno v:
Biomolecules, Vol 10, Iss 5, p 744 (2020)
Chemotaxis is an important virulence factor of the foodborne pathogen Campylobacter jejuni. Inactivation of chemoreceptor Tlp3 reduces the ability of C. jejuni to invade human and chicken cells and to colonise the jejunal mucosa of mice. Knowledge of
Externí odkaz:
https://doaj.org/article/ae3cea2aa03a44f4a5ffc221b9357a25
Publikováno v:
Crystals, Vol 8, Iss 10, p 391 (2018)
Colonization of Campylobacter concisus in the gastrointestinal tract can lead to the development of inflammatory bowel disease (IBD). Plasmid-encoded C. concisus-secreted protein 1 (Csep1p) was recently identified as a putative pathogenicity marker a
Externí odkaz:
https://doaj.org/article/ced9d445d04b461d8e1cd004eb82e72f
Autor:
Mohammad Mizanur Rahman, Daniel Phillip Germantsis, Mayra Alejandra Machuca, Abu Iftiaf Salah Ud-Din, Anna Roujeinikova
Publikováno v:
Crystals, Vol 7, Iss 11, p 330 (2017)
Helicobacter pylori infection can lead to the development of gastric and duodenal ulcers and gastric cancer. In recent years, the efficacy of the standard therapy has been falling, necessitating ongoing efforts to identify new drug targets. Due to th
Externí odkaz:
https://doaj.org/article/fc3b542eabda4db486fe08c0328c6878