Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Anna Reister Schultz"'
Autor:
Haijiao Zhang, Samantha Savage, Anna Reister Schultz, Daniel Bottomly, Libbey White, Erik Segerdell, Beth Wilmot, Shannon K. McWeeney, Christopher A. Eide, Tamilla Nechiporuk, Amy Carlos, Rachel Henson, Chenwei Lin, Robert Searles, Hoang Ho, Yee Ling Lam, Richard Sweat, Courtney Follit, Vinay Jain, Evan Lind, Gautam Borthakur, Guillermo Garcia-Manero, Farhad Ravandi, Hagop M. Kantarjian, Jorge Cortes, Robert Collins, Daelynn R. Buelow, Sharyn D. Baker, Brian J. Druker, Jeffrey W. Tyner
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
FLT3 is commonly mutated in acute myeloid leukaemia and treatment with FLT3 inhibitors often ends with relapse. Here, the authors perform exome sequencing of samples from patients treated with the FLT3 inhibitor, crenolanib, to show that resistance o
Externí odkaz:
https://doaj.org/article/998f439604e74cef95464ecda676fa5a
Autor:
Jeffrey W. Tyner, Oliver Hantschel, Tim Kükenshöner, Shannon K. McWeeney, Beth Wilmot, Daniel Bottomly, Bruno C. Medeiros, Kevin Watanabe-Smith, Anna Reister Schultz, Sophie Means, Haijiao Zhang
This file contains a table listing somatic mutations identified by Exome sequencing in the index patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85088af5c96085f20387ee8860f3bdd4
https://doi.org/10.1158/0008-5472.22414889
https://doi.org/10.1158/0008-5472.22414889
Autor:
Jeffrey W. Tyner, Oliver Hantschel, Tim Kükenshöner, Shannon K. McWeeney, Beth Wilmot, Daniel Bottomly, Bruno C. Medeiros, Kevin Watanabe-Smith, Anna Reister Schultz, Sophie Means, Haijiao Zhang
This file contains additional data such as detailed sequencing methods; Sanger sequencing result; receptor expression and function of R308 and double cysteine mutations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e8bfcc5bed888de206909d4da07eae1
https://doi.org/10.1158/0008-5472.22414892
https://doi.org/10.1158/0008-5472.22414892
Autor:
Craig M. Crews, Brian J. Druker, Samantha L. Savage Stevens, Christopher A. Eide, Daniel P. Bondeson, Anna Reister Schultz, George M. Burslem
Supplemental Figures and Tables. Figure S1 - Immunoblotting characterization of GMB-101 and GMB-475. Figure S2 - Validation of degradation and compound toxicity via comparison of GMB-475 and GMB-651. Figure S3 - Combinations of ATP competitive TKIs w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c16edb5114867b4d870998a6ddd8d8
https://doi.org/10.1158/0008-5472.22421222
https://doi.org/10.1158/0008-5472.22421222
Autor:
Jeffrey W. Tyner, Oliver Hantschel, Tim Kükenshöner, Shannon K. McWeeney, Beth Wilmot, Daniel Bottomly, Bruno C. Medeiros, Kevin Watanabe-Smith, Anna Reister Schultz, Sophie Means, Haijiao Zhang
Exclusive of membrane-proximal mutations seen commonly in chronic neutrophilic leukemia (e.g., T618I), functionally defective mutations in the extracellular domain of the G-CSF receptor (CSF3R) have been reported only in severe congenital and idiopat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d3e05fd2f6cc57d2faf698aaf5c1574
https://doi.org/10.1158/0008-5472.c.6509105.v1
https://doi.org/10.1158/0008-5472.c.6509105.v1
Autor:
Jeffrey W. Tyner, Oliver Hantschel, Tim Kükenshöner, Shannon K. McWeeney, Beth Wilmot, Daniel Bottomly, Bruno C. Medeiros, Kevin Watanabe-Smith, Anna Reister Schultz, Sophie Means, Haijiao Zhang
The file contains a table demonstrating CSF3R targeted deep sequencing result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac159e35ee58e1f0eaeb660dfa3e185
https://doi.org/10.1158/0008-5472.22414886.v1
https://doi.org/10.1158/0008-5472.22414886.v1
Autor:
Craig M. Crews, Brian J. Druker, Samantha L. Savage Stevens, Christopher A. Eide, Daniel P. Bondeson, Anna Reister Schultz, George M. Burslem
Although the use of ATP-competitive tyrosine kinase inhibitors of oncoprotein BCR-ABL1 has enabled durable responses in patients with chronic myeloid leukemia (CML), issues of drug resistance and residual leukemic stem cells remain. To test whether t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::303718483b143ecef53849cdf7d02534
https://doi.org/10.1158/0008-5472.c.6510863.v1
https://doi.org/10.1158/0008-5472.c.6510863.v1
Autor:
Stefan D Gross, Christopher A. Eide, Michael R Burkard, Anna Reister Schultz, Monette A Aujay, Samuel Kintz, Brian J. Druker, Joseph P Lyssikatos
Publikováno v:
Blood. 140:3095-3096
Autor:
Mara W, Rosenberg, Samantha L, Savage, Christopher A, Eide, Anna, Reister Schultz, Rachel J, Cook, Richard D, Press, Carole, Rempfer, Garrett, Eickelberg, Beth, Wilmot, Shannon K, McWeeney, Jeffrey W, Tyner, Brian J, Druker, Cristina E, Tognon
Publikováno v:
Cold Spring Harbor molecular case studies. 8(6)
The Philadelphia chromosome (Ph) resulting from the t(9;22) translocation generates the oncogenic BCR::ABL1 fusion protein that is most commonly associated with chronic myeloid leukemia (CML) and Ph-positive (Ph+) acute lymphoblastic leukemia (ALL).
Autor:
James S. Blachly, Anna Reister Schultz, Maximilian Schmutz, Christopher C. Oakes, Brian J. Druker, Bethany L. Mundy-Bosse, Min Wang, Sebastian Vosberg, Ramiro Garzon, Lars Bullinger, Philipp A. Greif, Ann-Kathrin Eisfeld, Rainer Claus, John C. Byrd, Clara D. Bloomfield, Yue Zhong Wu, Kevin R. Coombes, Brian Giacopelli, Ada C Cleary, Jeffrey W. Tyner
Publikováno v:
Genome Res
Genome Res. 31, 747-761 (2021)
Genome Res. 31, 747-761 (2021)
Acute myeloid leukemia (AML) is a molecularly complex disease characterized by heterogeneous tumor genetic profiles and involving numerous pathogenic mechanisms and pathways. Integration of molecular data types across multiple patient cohorts may adv