Distribution of Lewy-related pathology in the brain, spinal cord, and periphery: the population-based Vantaa 85 + study

Autor: Anna Raunio, Ville Kivistö, Mia Kero, Jarno Tuimala, Sara Savola, Minna Oinas, Eloise Kok, Kia Colangelo, Anders Paetau, Tuomo Polvikoski, Pentti J. Tienari, Henri Puttonen, Liisa Myllykangas

Publikováno v: Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-12 (2022)

Abstract Evolving evidence has supported the existence of two anatomically distinct Lewy-related pathology (LRP) types. Investigation of spinal cord and peripheral LRP can elucidate mechanisms of Lewy body disorders and origins of synuclein accumulat

Externí odkaz: https://doaj.org/article/2912458944eb46dea1ce4928ea95aaec

Neuropathological evidence of body-first vs. brain-first Lewy body disease

Autor: Per Borghammer, Jacob Horsager, Katrine Andersen, Nathalie Van Den Berge, Anna Raunio, Shigeo Murayama, Laura Parkkinen, Liisa Myllykangas

Publikováno v: Neurobiology of Disease, Vol 161, Iss , Pp 105557- (2021)

Aggregation of alpha-synuclein into inclusion bodies, termed Lewy pathology, is a defining feature of Parkinson's disease (PD) and Dementia with Lewy bodies (DLB). In the majority of post mortem cases, the distribution of Lewy pathology seems to foll

Externí odkaz: https://doaj.org/article/e724fb4b6980453890175ae589978beb

Neuropathological evidence of body-first vs. brain-first Lewy body disease

Autor: Anna Raunio, Nathalie Van Den Berge, Laura Parkkinen, Liisa Myllykangas, Jacob Horsager, Per Borghammer, Katrine B. Andersen, Shigeo Murayama

Publikováno v: Neurobiology of Disease, Vol 161, Iss, Pp 105557-(2021)
Borghammer, P, Horsager, J, Andersen, K, Van Den Berge, N, Raunio, A, Murayama, S, Parkkinen, L & Myllykangas, L 2021, ' Neuropathological evidence of body-first vs. brain-first Lewy body disease ', Neurobiology of Disease, vol. 161, 105557 . https://doi.org/10.1016/j.nbd.2021.105557

Aggregation of alpha-synuclein into inclusion bodies, termed Lewy pathology, is a defining feature of Parkinson's disease (PD) and Dementia with Lewy bodies (DLB). In the majority of post mortem cases, the distribution of Lewy pathology seems to foll

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34738bb50913952df65da4d06719929d
http://www.sciencedirect.com/science/article/pii/S0969996121003065

Hippocampal Sclerosis in the Oldest Old : A Finnish Population-Based Study

Autor: Tuomo Polvikoski, Mia Kero, Pentti J. Tienari, Anna Raunio, Liisa Myllykangas, Anders Paetau

Publikováno v: Journal of Alzheimer's Disease

Background: There are only few population-based studies that have systemically investigated the prevalence of hippocampal sclerosis (HS) in the very old. The frequency of unilateral versus bilateral HS has been rarely studied. Objective: We investiga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8967bd303b60be5068f0c27d2f8a74
http://hdl.handle.net/10138/235228

Amygdala α-Synuclein Pathology in the Population-Based Vantaa 85+ Study

Autor: Tuomo Polvikoski, Minna Oinas, Anders Paetau, Anna Raunio, Liisa Myllykangas, Mia Kero

Publikováno v: Journal of Alzheimer's Disease

We investigated the frequency of Lewy-related pathology (LRP) in the amygdala among the population-based Vantaa 85+ study. Data of amygdala samples (N = 304) immunostained with two α-synuclein antibodies (clone 42 and clone 5G4) was compared with th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba0f2ed0fb8f765f71cdc6dede0ac7b
https://pubmed.ncbi.nlm.nih.gov/28482633