Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Anna R. Cliffe"'
Autor:
Alison K. Francois, Ali Rohani, Matt Loftus, Sara Dochnal, Joel Hrit, Steven McFarlane, Abigail Whitford, Anna Lewis, Patryk Krakowiak, Chris Boutell, Scott B. Rothbart, David Kashatus, Anna R. Cliffe
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTThe fate of herpesvirus genomes following entry into different cell types is thought to regulate the outcome of infection. For the Herpes simplex virus 1 (HSV-1), latent infection of neurons is characterized by association with repressive het
Externí odkaz:
https://doaj.org/article/63ac7e096c154504b5aaf7c57f3b8b2f
Publikováno v:
Viruses, Vol 13, Iss 8, p 1470 (2021)
The Human Herpesviruses persist in the form of a latent infection in specialized cell types. During latency, the herpesvirus genomes associate with cellular histone proteins and the viral lytic genes assemble into transcriptionally repressive heteroc
Externí odkaz:
https://doaj.org/article/c02d636ae6ea4072a6443690b407fd11
Publikováno v:
mBio, Vol 4, Iss 1 (2013)
ABSTRACT The herpes simplex virus (HSV) genome is associated with heterochromatic histone modifications, including trimethylation of the lysine 27 residue of histone H3 (H3K27me3), during latent infection of neurons. Here we have examined the kinetic
Externí odkaz:
https://doaj.org/article/3844149ee7ec4c3ea534b3ec717b178a
Autor:
Abigail L Whitford, Anna R Cliffe
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010587 (2022)
Externí odkaz:
https://doaj.org/article/2691fd45933b49a9b96db1770dcc0e8d
Autor:
Sean R Cuddy, Austin R Schinlever, Sara Dochnal, Philip V Seegren, Jon Suzich, Parijat Kundu, Taylor K Downs, Mina Farah, Bimal N Desai, Chris Boutell, Anna R Cliffe
Publikováno v:
eLife, Vol 9 (2020)
Herpes simplex virus-1 (HSV-1) establishes a latent infection in neurons and periodically reactivates to cause disease. The stimuli that trigger HSV-1 reactivation have not been fully elucidated. We demonstrate HSV-1 reactivation from latently infect
Externí odkaz:
https://doaj.org/article/0fb97c7a33404ae3886ae03f37e70bc9
Autor:
Sean R. Cuddy, Anna R. Cliffe
Publikováno v:
Journal of Virology. 97
Innate immune responses can impact different stages of viral life cycles. Herpes simplex virus latent infection of neurons and subsequent reactivation provide a unique context for immune responses to intersect with different stages of infection.
Autor:
Andreja Zubković, Cristina Gómez-Martín, Adwait Anand Parchure, Mia Cesarec, Antun Ferenčić, Filip Rokić, Hrvoje Jakovac, Abigail L Whitford, Sara A Dochnal, Anna R. Cliffe, Dražen Cuculić, Angela Gallo, Oliver Vugrek, MIchael Hackenberg, Igor Jurak
Viruses use miRNAs to enable efficient replication, control host defense mechanisms, and regulate latent infection. Herpes simplex virus 1 (HSV-1) expresses multiple miRNAs, whose functions are largely unknown. The evolutionary conservation of many H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbdfd163c4349a09a32519ad9b086fa9
https://doi.org/10.1101/2023.05.26.542484
https://doi.org/10.1101/2023.05.26.542484
Autor:
Sara Dochnal, Husain Y. Merchant, Austin R. Schinlever, Aleksandra Babnis, Daniel P. Depledge, Angus C. Wilson, Anna R. Cliffe
Publikováno v:
J Virol
Understanding the molecular mechanism of herpes simplex virus type 1 (HSV-1) latent infection and reactivation in neurons requires the use of model systems. However, establishing a quiescent infection in cultured neurons is problematic as infectious
Autor:
Abigail L. Whitford, Corinne A. Clinton, E. B. Lane Kennedy, Sara A. Dochnal, Jon B. Suzich, Anna R. Cliffe
Publikováno v:
J Virol
Herpes simplex virus 1 (HSV-1) maintains a lifelong latent infection in neurons and periodically reactivates, resulting in the production of infectious virus. The exact cellular pathways that induce reactivation are not understood. In primary neurona
Autor:
Abigail L. Whitford, Corinne A. Clinton, E.B. Lane Kennedy, Sara A. Dochnal, Jon B. Suzich, Anna R. Cliffe
Herpes Simplex virus-1 (HSV-1) maintains a lifelong latent infection in neurons and periodically reactivates, resulting in the production of infectious virus. The exact cellular pathways that induce reactivation are not understood. In primary neurona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::495d746f2b2ced891e09919a3c62f4f9
https://doi.org/10.1101/2022.02.25.481951
https://doi.org/10.1101/2022.02.25.481951