Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Anna R Carta"'
Autor:
Marzia Indrigo, Ilaria Morella, Daniel Orellana, Raffaele d'Isa, Alessandro Papale, Riccardo Parra, Antonia Gurgone, Daniela Lecca, Anna Cavaccini, Cezar M Tigaret, Alfredo Cagnotto, Kimberley Jones, Simon Brooks, Gian Michele Ratto, Nicholas D Allen, Mariah J Lelos, Silvia Middei, Maurizio Giustetto, Anna R Carta, Raffaella Tonini, Mario Salmona, Jeremy Hall, Kerrie Thomas, Riccardo Brambilla, Stefania Fasano
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp n/a-n/a (2023)
Abstract Cell signaling is central to neuronal activity and its dysregulation may lead to neurodegeneration and cognitive decline. Here, we show that selective genetic potentiation of neuronal ERK signaling prevents cell death in vitro and in vivo in
Externí odkaz:
https://doaj.org/article/07ec956f4df240a18ad3746f40460254
Autor:
Maria Scherma, Maria Francesca Palmas, Augusta Pisanu, Paolo Masia, Simona Dedoni, Chiara Camoglio, Walter Fratta, Anna R. Carta, Paola Fadda
Publikováno v:
Nutrients, Vol 15, Iss 17, p 3830 (2023)
Anorexia nervosa (AN) is a complex eating disorder characterized by reduced caloric intake to achieve body-weight loss. Furthermore, over-exercise is commonly reported. In recent years, animal models of AN have provided evidence for neuroplasticity c
Externí odkaz:
https://doaj.org/article/c6384681a1d44592b5440b0ebd629fbf
Autor:
Ezio Carboni, Anna R. Carta
Publikováno v:
Journal of Integrative Neuroscience, Vol 21, Iss 5, p 144 (2022)
Major depressive disorder is one of the primary causes of disability and disease worldwide. The therapy of depression is prevalently based on monoamine reuptake blockers; consequently, investigations aimed to clarify the aetiology of depression have
Externí odkaz:
https://doaj.org/article/f98ca508ddf64749b032654e64830f77
Autor:
Maria Francesca Palmas, Michela Etzi, Augusta Pisanu, Chiara Camoglio, Claudia Sagheddu, Michele Santoni, Maria Francesca Manchinu, Mauro Pala, Giuliana Fusco, Alfonso De Simone, Luca Picci, Giovanna Mulas, Saturnino Spiga, Maria Scherma, Paola Fadda, Marco Pistis, Nicola Simola, Ezio Carboni, Anna R. Carta
Publikováno v:
Cells, Vol 11, Iss 17, p 2628 (2022)
Parkinson’s disease (PD) is a complex pathology causing a plethora of non-motor symptoms besides classical motor impairments, including cognitive disturbances. Recent studies in the PD human brain have reported microgliosis in limbic and neocortica
Externí odkaz:
https://doaj.org/article/3eedc67be715406cbd276027691c9ffd
Autor:
Giulia Di Benedetto, Chiara Burgaletto, Anna R. Carta, Salvatore Saccone, Laurence Lempereur, Giovanna Mulas, Carla Loreto, Renato Bernardini, Giuseppina Cantarella
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-17 (2019)
Abstract Background Currently, there are no effective therapeutic options for Alzheimer’s disease, the most common, multifactorial form of dementia, characterized by anomalous amyloid accumulation in the brain. Growing evidence points to neuroinfla
Externí odkaz:
https://doaj.org/article/5b3d2f646b2345b58927556b6c14dce2
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Repurposing ketamine in the therapy of depression could well represent a breakthrough in understanding the etiology of depression. Ketamine was originally used as an anesthetic drug and later its use was extended to other therapeutic applications suc
Externí odkaz:
https://doaj.org/article/bd5956fe57ab46d5b4f96f4fdd337dd3
Repurposing Immunomodulatory Imide Drugs (IMiDs) in Neuropsychiatric and Neurodegenerative Disorders
Autor:
Yoo Jin Jung, David Tweedie, Michael T. Scerba, Dong Seok Kim, Maria Francesca Palmas, Augusta Pisanu, Anna R. Carta, Nigel H. Greig
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Neuroinflammation represents a common trait in the pathology and progression of the major psychiatric and neurodegenerative disorders. Neuropsychiatric disorders have emerged as a global crisis, affecting 1 in 4 people, while neurological disorders a
Externí odkaz:
https://doaj.org/article/9646c29fec9d42168ac9907f0232eade
Autor:
Maria Antonietta Casu, Ignazia Mocci, Raffaella Isola, Augusta Pisanu, Laura Boi, Giovanna Mulas, Nigel H. Greig, Maria Dolores Setzu, Anna R. Carta
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
The search for new disease-modifying drugs for Parkinson’s disease (PD) is a slow and highly expensive process, and the repurposing of drugs already approved for different medical indications is becoming a compelling alternative option for research
Externí odkaz:
https://doaj.org/article/0fd9fc7c6a714725a54eba324e1c4037
Autor:
Laura Boi, Augusta Pisanu, Maria Francesca Palmas, Giuliana Fusco, Ezio Carboni, Maria Antonietta Casu, Valentina Satta, Maria Scherma, Elzbieta Janda, Ignazia Mocci, Giovanna Mulas, Anna Ena, Saturnino Spiga, Paola Fadda, Alfonso De Simone, Anna R. Carta
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8535 (2020)
The accumulation of aggregated α-synuclein (αSyn) is a hallmark of Parkinson’s disease (PD). Current evidence indicates that small soluble αSyn oligomers (αSynOs) are the most toxic species among the forms of αSyn aggregates, and that size and
Externí odkaz:
https://doaj.org/article/03241811a4b9437d8aa33d3e64f30208
Autor:
Federica Murgia, Luigi Atzori, Ezio Carboni, Maria Laura Santoru, Aran Hendren, Augusta Pisanu, Pierluigi Caboni, Laura Boi, Giuliana Fusco, Anna R. Carta
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 18, p 6745 (2020)
Parkinson’s disease (PD) is considered a synucleinopathy because of the intraneuronal accumulation of aggregated α-synuclein (αSyn). Recent evidence points to soluble αSyn-oligomers (αSynO) as the main cytotoxic species responsible for cell dea
Externí odkaz:
https://doaj.org/article/df3f923210bf43eb9f63d7e8bee7279b