Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Anna Qiao"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
The rhodopsin-like receptor GPR119 plays a crucial role in glucose homeostasis and is an emerging target for the treatment of type 2 diabetes mellitus. In this study, we analyzed the structure of GPR119 with the agonist APD597 bound and in complex wi
Externí odkaz:
https://doaj.org/article/9663fb2b8de24d618a49648e6891b8a3
Autor:
Yuxia Qian, Jiening Wang, Linlin Yang, Yanru Liu, Lina Wang, Wei Liu, Yun Lin, Hong Yang, Lixin Ma, Sheng Ye, Shan Wu, Anna Qiao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Agonists selectively targeting GPR119 hold promise for treating metabolic disorders. Here, authors reveal that GPR119 adopts a non-canonical consensus structural scaffold with an extended ligand-binding pocket for chemically different agonists.
Externí odkaz:
https://doaj.org/article/1a5e75195b15441ab9ae910d66ae194b
Autor:
Anna Qiao1,2,3, Shuo Han1,2, Xinmei Li3,4, Zhixin Li5, Peishen Zhao6, Antao Dai1,7, Rulve Chang5, Linhua Tai3,4, Qiuxiang Tan1,2, Xiaojing Chu1,2, Limin Ma1,2, Thorsen, Thor Seneca8, Reedtz-Runge, Steffen8, Dehua Yang1,7, Ming-Wei Wang1,3,5,7, Sexton, Patrick M.5,6, Wootten, Denise5,6 denise.wootten@monash.edu, Fei Sun3,4,9 feisun@ibp.ac.cn, Qiang Zhao2,3,10 zhaoq@simm.ac.cn, Beili Wu1,3,10,11 beiliwu@simm.ac.cn
Publikováno v:
Science. 3/20/2020, Vol. 367 Issue 6484, p1346-1352. 7p. 4 Diagrams.
Autor:
Denise Wootten, Guangyao Lin, Qiuxiang Tan, Li Zhong, Ming-Wei Wang, Patrick M. Sexton, Rulue Chang, Antao Dai, Radostin Danev, Matthew J. Belousoff, Shuo Han, Yi Lynn Liang, Dehua Yang, Xin Zhang, Anna Qiao, Lijun Shao, Beili Wu, Limin Ma
Publikováno v:
J Biol Chem
Unimolecular dual agonists of the glucagon (GCG) receptor (GCGR) and glucagon-like peptide-1 receptor (GLP-1R) are a new class of drugs that are potentially superior to GLP-1R–specific agonists for the management of metabolic disease. The dual-agon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49688bee82635a26227737dda46db30
https://europepmc.org/articles/PMC7363120/
https://europepmc.org/articles/PMC7363120/
Autor:
Linlin Yang, Xianping Wang, Raymond C. Stevens, Ye Zhou, Cuiying Yi, Beili Wu, Qiuxiang Tan, Gye Won Han, Hualiang Jiang, Jianfeng Liu, Xuejun Cai Zhang, Qiang Zhao, Xuemei Li, Can Cao, Huaiyu Yang, Anna Qiao, Minmin Lu, Yongfang Zhao, Yiwei Zhou, Chanjuan Xu, Zihe Rao, Lingli He
Publikováno v:
Nature Structural & Molecular Biology. 25:488-495
Platelet-activating-factor receptor (PAFR) responds to platelet-activating factor (PAF), a phospholipid mediator of cell-to-cell communication that exhibits diverse physiological effects. PAFR is considered an important drug target for treating asthm
Autor:
Venkatasubramanian Dharmarajan, Anna Qiao, Xiaoai Wu, Guangyao Lin, Raymond G. Sierra, Michael A. Hanson, Patrick R. Griffin, Gye Won Han, Thomas D. Grant, Hui Zhang, Yanhong Wu, Steffen Reedtz-Runge, Linlin Yang, Haonan Zhang, Dehua Yang, Ming-Wei Wang, Wei Liu, Hualiang Jiang, Huaiyu Yang, Garrett Nelson, Xiaoqing Cai, Yuhui Dong, Raymond C. Stevens, Beili Wu, Antao Dai, Vadim Cherezov, Zhi Geng, Uwe Weierstall, Gaojie Song, Chris de Graaf, Limin Ma, Qiang Zhao, Jesper Lau
Publikováno v:
Zhang, H, Qiao, A, Yang, D, Yang, L, Dai, A, de Graaf, C, Reedtz-Runge, S, Dharmarajan, V, Zhang, H, Han, G W, Grant, T D, Sierra, R G, Weierstall, U, Nelson, G, Liu, W, Wu, Y, Ma, L, Cai, X, Lin, G, Wu, X, Geng, Z, Dong, Y, Song, G, Griffin, P R, Lau, J, Cherezov, V, Yang, H, Hanson, M A, Stevens, R C, Zhao, Q, Jiang, H, Wang, M W & Wu, B 2017, ' Structure of the full-length glucagon class B G-protein-coupled receptor ', Nature, vol. 546, no. 7657, pp. 259-264 . https://doi.org/10.1038/nature22363
Nature
Nature, 546(7657), 259-264. Nature Publishing Group
Nature
Nature, 546(7657), 259-264. Nature Publishing Group
The human glucagon receptor, GCGR, belongs to the class B G-protein-coupled receptor family and plays a key role in glucose homeostasis and the pathophysiology of type 2 diabetes. Here we report the 3.0 Å crystal structure of full-length GCGR contai
Autor:
Anna, Qiao, Shuo, Han, Xinmei, Li, Zhixin, Li, Peishen, Zhao, Antao, Dai, Rulve, Chang, Linhua, Tai, Qiuxiang, Tan, Xiaojing, Chu, Limin, Ma, Thor Seneca, Thorsen, Steffen, Reedtz-Runge, Dehua, Yang, Ming-Wei, Wang, Patrick M, Sexton, Denise, Wootten, Fei, Sun, Qiang, Zhao, Beili, Wu
Publikováno v:
Science (New York, N.Y.). 367(6484)
Class B G protein-coupled receptors, an important class of therapeutic targets, signal mainly through the G
Autor:
Anna Qiao, Huaiyu Yang, Antao Dai, Cuiying Yi, Hualiang Jiang, Jesper Lau, Ming-Wei Wang, Ned Van Eps, Steffen Reedtz-Runge, Hui Zhang, Raymond C. Stevens, Klaus Stensgaard Frederiksen, Linlin Yang, Michael A. Hanson, Can Cao, Lingli He, Oliver P. Ernst, Dehua Yang, Beili Wu, Haonan Zhang, Qiang Zhao, Xiaoqing Cai
Publikováno v:
Nature. 553(7686)
The crystal structure of the full-length glucagon receptor in complex with a glucagon analogue NNC1702 reveals how the peptide ligand interacts with its target and shows the conformational changes required for receptor activation. The glucagon recept
Autor:
Anna Qiao, Steven Zhang
Publikováno v:
Journal of Loss Prevention in the Process Industries. 23:843-848
The main objective of this study is to quantify the potential overpressures due to Vapor Cloud Explosions (VCEs) and the potential gas buildup by using Computation Fluid Dynamics (CFD) for onshore or offshore facilities. A series of CFD simulations a
Autor:
Rulue Chang1, Xin Zhang2, Anna Qiao3,4, Antao Dai3,5, Belousoff, Matthew J.2, Qiuxiang Tan3,4, Lijun Shao3,4,6, Li Zhong3,4, Guangyao Lin3,4,6, Yi-Lynn Liang2, Limin Ma3, Shuo Han3, Dehua Yang3,5, Radostin Danev7, Ming-Wei Wang1,3,4,5,6 mwwang@simm.ac.cn, Wootten, Denise2 denise.wootten@monash.edu, Beili Wu3,4,6 beiliwu@simm.ac.cn, Sexton, Patrick M.2 Patrick.sexton@monash.edu
Publikováno v:
Journal of Biological Chemistry. 7/10/2020, Vol. 295 Issue 28, p9313-9325. 13p.