Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Anna Pućkowska"'
Autor:
Anna Puckowska, Magdalena Gawel, Marlena Komorowska, Pawel Drozdzal, Aleksandra Arning, Damian Pawelski, Krzysztof Brzezinski, Marta E. Plonska-Brzezinska
Publikováno v:
Molecules, Vol 27, Iss 6, p 1819 (2022)
Derivatives based on pyridine-2-6- and furan-2,5-dicarboxamide scaffolds reveal numerous chemical properties and biological activities. This fact makes them an exciting research topic in supramolecular and coordination chemistry and in discovering ne
Externí odkaz:
https://doaj.org/article/e4f5ebc25aaa46479d4d172c5d9fe1d1
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 19:98-113
The DNA as the depository of genetic information is a natural target for chemotherapy. A lot of anticancer and antimicrobial agents derive their biological activity from their selective interaction with DNA in the minor groove and from their ability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706666382716d31fc73047eab83c1dea
https://doi.org/10.2174/1389557518666181009143203
https://doi.org/10.2174/1389557518666181009143203
Autor:
José María Zapico, Pilar Serra, Ana Ramos, M. Bruczko, Mario A. García, B. de Pascual-Teresa, Anna Pućkowska, Sonsoles Martín-Santamaría
Publikováno v:
Current Medicinal Chemistry. 19:1036-1064
Extracellular matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases involved in physiological and pathological processes, through the cleavage of extracellular matrix. MMPs are capable of degrading essentially all mat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db1c8cdd20c827b477b67cd247c5d08
https://doi.org/10.2174/092986712799320628
https://doi.org/10.2174/092986712799320628
Autor:
Claire Coderch, José María Zapico, Kamila Filipiak, Beatriz de Pascual-Teresa, Ana Ramos, Anna Pućkowska
Publikováno v:
Organicbiomolecular chemistry. 13(1)
MMP-2 is a validated target for the development of anticancer agents. Herein we describe the synthesis of a new series of potent phenylalanine derived hydroxamates, with increased MMP-2/MMP-9 selectivity compared to analogous hydroxamates described p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dfbc77e02a19b65249122f53a363db4
https://pubmed.ncbi.nlm.nih.gov/25348733
https://pubmed.ncbi.nlm.nih.gov/25348733
Autor:
Anna, Pućkowska, Danuta, Drozdowska, Małgorzata, Rusak, Tomasz, Bielawski, Irena, Bruzgo, Krystyna, Midura-Nowaczek
Publikováno v:
Acta poloniae pharmaceutica. 69(1)
The amino analogues of pentamidine with a polymethylene (n = 3 - 6) chain and their chlorambucil derivatives were synthesized. The obtained compounds revealed cytotoxic effect on MCF-7 human breast cancer cell line (IC50 = 22 - 95 +/- 2 pM), mainly b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::58affdf4123f434f6c73f923dd9e4f44
https://pubmed.ncbi.nlm.nih.gov/22574508
https://pubmed.ncbi.nlm.nih.gov/22574508
Publikováno v:
Acta poloniae pharmaceutica. 65(2)
Inhibitory effects of nine carbocyclic DNA minor groove binders on amidolytic activities of plasmin, trypsin and urokinase were examined. Some of the studied compounds affected plasmin or trypsin activity, but not urokinase activity. One of the penta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ee226e1991f653f1562a85201773c577
https://pubmed.ncbi.nlm.nih.gov/18666427
https://pubmed.ncbi.nlm.nih.gov/18666427
Publikováno v:
Acta poloniae pharmaceutica. 64(2)
A DNA-binding affinity and the effect on restriction enzymes activity of seven carbocyclic mono- and bis-lexitropsins and two analogues of pentamidine with unsubstituted N-terminal amine group were investigated. DNA association constants (Kapp) show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::568c0b3989c66aac21aba340c411eb35
https://pubmed.ncbi.nlm.nih.gov/17665860
https://pubmed.ncbi.nlm.nih.gov/17665860
Publikováno v:
Acta poloniae pharmaceutica. 62(1)
Four derivatives of benzotriazole-5-carboxylic acid were synthesized as potential UV-light dependent DNA cleaving agent. The effect of these compounds on phiX174 RF1 phage DNA and pBR322 plasmid DNA was investigated with and without UV exposure. It h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d9d9fbe7549403a8a86c4600d814d50f
https://pubmed.ncbi.nlm.nih.gov/16022495
https://pubmed.ncbi.nlm.nih.gov/16022495
Autor:
A Rózański, Krzysztof Bielawski, Bartulewicz D, Krzysztof Zwierz, Anna Pućkowska, Agnieszka Markowska
Publikováno v:
Europe PubMed Central
A new series of pyridine-containing analogues III-XXII of distamycin A and netrop sin was investigated by the molecular mechanics technique and molecular modelling. A pyridine analogue of netropsin (VII) is described, the first compound based on mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de65684adde2d49d1b561ff7e7cc4f89
https://pubmed.ncbi.nlm.nih.gov/9701495
https://pubmed.ncbi.nlm.nih.gov/9701495