Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Anna Podnos"'
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e113597 (2014)
We have compared cure from local/metastatic tumor growth in BALB/c mice receiving EMT6 or the poorly immunogenic, highly metastatic 4THM, breast cancer cells following manipulation of immunosuppressive CD200:CD200R interactions or conventional chemot
Externí odkaz:
https://doaj.org/article/866073cb8b784ddf975f0592dfe653fc
Publikováno v:
Breast Cancer Research and Treatment. 136:117-127
Previous studies reported that CD200 expression on cells of the transplantable EMT6 mouse breast cancer line was increased during growth in immunocompetent mice. Low levels of expression persisted in NOD-SCID.IL-2(γr-/-) mice or mice with generalize
Autor:
Anna Podnos, Adriana Taseva, Ivo Boudakov, Karrie Wong, Brent Lamptey, Reginald M. Gorczynski, Ismat Khatri
Publikováno v:
Open Journal of Immunology. :168-186
CD200:CD200R interactions regulate immune responses. Since CD200Rs show extensive homology in their extracellular region, generating anti-CD200R specific antibodies is a challenge. We report below on the generation of mAbs specific for murine (m)R1/R
Publikováno v:
Oncogene. 34(29)
CD200 acts through its receptor (CD200R) to inhibit excessive inflammation. The role of CD200-CD200R1 interaction in tumor immunity is poorly understood. In this study, we examined the role of CD200-CD200R1 interaction in the progression and metastas
Publikováno v:
The Journal of Immunology. 194:69.19-69.19
Attenuated expression of CD200 decreases local tumor growth and metastasis in immunocompetent animals. We explored the ability to cure BALB/c CD200KO or CD200R1KO mice of tumors ≤1cm3 in size by surgical resection of localized tumor, followed by im
Publikováno v:
The Journal of Immunology. 192:203.3-203.3
Attenuated expression of CD200 decreases local tumor growth and metastasis in immunocompetent animals. We explored the ability to cure BALB/c CD200KO or CD200R1KO mice of tumors ≤1cm3 in size by surgical resection of localized tumor, followed by im
Publikováno v:
The Journal of Immunology. 192:203.4-203.4
CD200 overexpression increases metastasis of tumor cells to draining lymph nodes. Increased levels of a soluble form of CD200, sCD200, occur in serum of ~50% breast cancer patients, and an immunoadhesin, linking CD200 to an immunoglobulin Fc region (
Publikováno v:
Breast Cancer Research and Treatment
In previous studies, we observed that regulation of expression of CD200, both on cells of a transplantable breast cancer, EMT6, and of the host, as well as of the receptor, CD200R in host mice, regulated local tumor growth and metastasis in immunocom