Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Anna P, Lam"'
Autor:
Paul A. Reyfman, Elizabeth S. Malsin, Basil Khuder, Nikita Joshi, Gaurav Gadhvi, Annette S. Flozak, Mary A. Carns, Kathleen Aren, Isaac A. Goldberg, Seokjo Kim, Michael Alexander, Peter H. S. Sporn, Alexander V. Misharin, G.R. Scott Budinger, Anna P. Lam, Monique Hinchcliff, Cara J. Gottardi, Deborah R. Winter
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 68:176-185
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef834d033f4b9fee594f27d3e0991cbd
https://doi.org/10.1165/rcmb.2021-0123oc
https://doi.org/10.1165/rcmb.2021-0123oc
Publikováno v:
Respiratory Medicine Case Reports, Vol 26, Iss , Pp 304-306 (2019)
Background: Mirabegron, a β3 adrenergic receptor agonist, is FDA approved for treatment of overactive bladder. Approved in 2012 in the US, there have been no reports of any effects of mirabegron on pulmonary function.Case presentation: We report the
Externí odkaz:
https://doaj.org/article/785cee57dd284b1e8b6aa215c537415e
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Macrophages are often viewed through the lens of their core functions, but recent transcriptomic studies reveal them to be largely distinct across tissue types. While these differences appear to be shaped by their local environment, the key signals t
Externí odkaz:
https://doaj.org/article/358c81f41cb344f2aef97491fc502301
Autor:
Ahmet Z Uluer, Gordon MacGregor, Pilar Azevedo, Veronica Indihar, Claire Keating, Marcus A Mall, Edward F McKone, Bonnie W Ramsey, Steven M Rowe, Ronald C Rubenstein, Jennifer L Taylor-Cousar, Elizabeth Tullis, Lael M Yonker, Chenghao Chu, Anna P Lam, Nitin Nair, Patrick R Sosnay, Simon Tian, Fredrick Van Goor, Lakshmi Viswanathan, David Waltz, Linda T Wang, Yingmei Xi, Joanne Billings, Alexander Horsley, Edward F. Nash, Marleen Bakker, Renske van der Meer, Petrus Merkus, Christof Majoor, Karen McCoy, Krishna Pancham, James Tolle, Bryon Quick, Ahmet Uluer, Emily DiMango, Adupa Rao, Santiago Reyes, Ross Klingsberg, Celeste Barreto, Victor Ortega, Donna Willey-Courand, Carsten Schwarz, Sivagurunathan Sutharsan, Rainald Fischer, Jane Davies, Jamie Duckers, Simon Doe, Harry Heijerman, George M. Solomon, Christian Merlo, Jennifer Griffonnet, Joseph Pilewski, Jordan Dunitz, Saba Sheikh, Ronald C. Rubenstein, Daniel B. Rosenbluth, Theodore Liou, Maria Indihar, Lael Yonker, Samya Nasr, Cynthia D. Brown, Gregory S. Sawicki, Jennifer Ruddy, Bryan Garcia, Andrew Braun, Alex H. Gifford, Nighat Mehdi, Maria Tupayachi Ortiz, Raksha Jain, Francisco J. Calimano, Jimmy Johannes, Cori L. Daines, Jason Fullmer, Joel Mermis, Christopher Barrios, Ngoc Ly, Brian P. Casserly, Stephan Eisenmann, Helge Hebestreit, Alexander Kiefer, Daniel Peckham, Martin Ledson, Eva Van Braeckel, Noel Gerard McElvaney, Edward McKone, Barry Plant, Lucy Burr, Daniel J. Smith, Peter Middleton, John Wilson
Publikováno v:
The Lancet Respiratory Medicine, 11(6), 550-562. Elsevier Limited
VX18-121-101 & VX18-561-101 Study Groups 2023, ' Safety and efficacy of vanzacaftor–tezacaftor–deutivacaftor in adults with cystic fibrosis : randomised, double-blind, controlled, phase 2 trials ', The Lancet Respiratory Medicine, vol. 11, no. 6, pp. 550-562 . https://doi.org/10.1016/S2213-2600(22)00504-5
LANCET RESPIRATORY MEDICINE
VX18-121-101 & VX18-561-101 Study Groups 2023, ' Safety and efficacy of vanzacaftor–tezacaftor–deutivacaftor in adults with cystic fibrosis : randomised, double-blind, controlled, phase 2 trials ', The Lancet Respiratory Medicine, vol. 11, no. 6, pp. 550-562 . https://doi.org/10.1016/S2213-2600(22)00504-5
LANCET RESPIRATORY MEDICINE
Background: Elexacaftor–tezacaftor–ivacaftor has been shown to be safe and efficacious in people with cystic fibrosis and at least one F508del allele. Our aim was to identify a novel cystic fibrosis transmembrane conductance regulator (CFTR) modu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b19fd4ef9823a3f92122d18b15dec4
https://research.vumc.nl/en/publications/0a8b171c-28b7-4da9-8e4a-5749733cacf9
https://research.vumc.nl/en/publications/0a8b171c-28b7-4da9-8e4a-5749733cacf9
Autor:
Paul A, Reyfman, Elizabeth S, Malsin, Basil, Khuder, Nikita, Joshi, Gaurav, Gadhvi, Annette S, Flozak, Mary A, Carns, Kathleen, Aren, Isaac A, Goldberg, Seokjo, Kim, Michael, Alexander, Peter H S, Sporn, Alexander V, Misharin, G R Scott, Budinger, Anna P, Lam, Monique, Hinchcliff, Cara J, Gottardi, Deborah R, Winter
Publikováno v:
American journal of respiratory cell and molecular biology.
Tissue availability remains an important limitation of single-cell genomic technologies for investigating cellular heterogeneity in human health and disease. Bronchoalveolar lavage (BAL) represents a minimally invasive approach to assess an individua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::58f426d1ca1bc7263ff1d3e6ae3c328c
https://pubmed.ncbi.nlm.nih.gov/36174229
https://pubmed.ncbi.nlm.nih.gov/36174229
Autor:
Sivagurunathan Sutharsan, Edward F McKone, Damian G Downey, Jamie Duckers, Gordon MacGregor, Elizabeth Tullis, Eva Van Braeckel, Claire E Wainwright, Danie Watson, Neil Ahluwalia, Bote G Bruinsma, Christopher Harris, Anna P Lam, Yiyue Lou, Samuel M Moskowitz, Simon Tian, Jason Yuan, David Waltz, Marcus A Mall, Paul Aurora, Stijn Verhulst, Michael Lorenz, Jobst Roehmel, Wolfgang Gleiber, Susanne Naehrig, Florian Stehling, Silke van Koningsbruggen-Rietschel, Rainald Fischer, Damian Downey, Charles Haworth, Julian Legg, Peter Barry, Rebecca Thursfield, Simon James Doe, Tom Hilliard, Edward F Nash, Nicholas John Withers, Daniel Peckham, Helen Louise Barr, Timothy Lee, Robert Gray, Francois Vermeulen, Eef Vanderhelst, Philip J Robinson, Daniel J Smith, Siobhain A Mulrennan, Barry S Clements, Peter Wark
Publikováno v:
VX18-445-109 study group 2021, ' Efficacy and safety of elexacaftor plus tezacaftor plus ivacaftor versus tezacaftor plus ivacaftor in people with cystic fibrosis homozygous for F508del-CFTR: a 24-week, multicentre, randomised, double-blind, active-controlled, phase 3b trial ', The Lancet. Respiratory medicine . https://doi.org/10.1016/S2213-2600(21)00454-9
BackgroundElexacaftor plus tezacaftor plus ivacaftor is a triple-combination cystic fibrosis transmembrane conductance regulator (CFTR) modulator regimen shown to be generally safe and efficacious in people with cystic fibrosis aged 12 years or older
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c34a7aa3d2d4d1a01b05a402f021fc
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85124502293
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85124502293
Autor:
Monique Hinchcliff, Monica Chi, Manu Jain, Anna P. Lam, Vince K. Morgan, Gökhan M. Mutlu, Ali Shilatifard, Luís A. Nunes Amaral, A. Christine Argento, Satoshi Watanabe, Robert D. Guzy, SeungHye Han, Ankit Bharat, Colin T. Gillespie, Stacy A. Marshall, Kishore R. Anekalla, Ching I. Chen, Kiwon Nam, Alexandra C. McQuattie-Pimentel, Alexander V. Misharin, Remzi Bag, Annette S. Flozak, Harris Perlman, Karen M. Ridge, Rohan Verma, Benjamin D. Singer, James M. Walter, Jane Dematte, Catherine A. Bonham, Stephen Chiu, Ramiro Fernandez, Ziyou Ren, Cara L. Hrusch, Saul Soberanes, Anjana Yeldandi, Francisco J. Gonzalez-Gonzalez, Nikita Joshi, Hiam Abdala-Valencia, Trevor T. Nicholson, G. R. Scott Budinger, Sangeeta Bhorade, Anne I. Sperling, Paul A. Reyfman, Mahzad Akbarpour, Jacob I. Sznajder, Deborah R. Winter, Robert B. Hamanaka, Kinola J.N. Williams, Cara J. Gottardi
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
Rationale: The contributions of diverse cell populations in the human lung to pulmonary fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal changes within individual cell populations during pulmonary fibrosis that are i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b5b08bd503f998ca7b47f22338bd3f5
https://doi.org/10.1164/rccm.201712-2410oc
https://doi.org/10.1164/rccm.201712-2410oc
Autor:
Anna P. Lam, Thomas C. Corbridge
Publikováno v:
The Scientific World Journal, Vol 7, Pp 80-82 (2007)
Externí odkaz:
https://doaj.org/article/371f14bf8da9492fb336c5acef05865d
Autor:
Roberto M Barrozo, Cara L Cooke, Lori M Hansen, Anna M Lam, Jennifer A Gaddy, Elizabeth M Johnson, Taryn A Cariaga, Giovanni Suarez, Richard M Peek, Timothy L Cover, Jay V Solnick
Publikováno v:
PLoS Pathogens, Vol 9, Iss 2, p e1003189 (2013)
Helicobacter pylori causes clinical disease primarily in those individuals infected with a strain that carries the cytotoxin associated gene pathogenicity island (cagPAI). The cagPAI encodes a type IV secretion system (T4SS) that injects the CagA onc
Externí odkaz:
https://doaj.org/article/b65e978879024fac91d09c8853f267fc
Autor:
G. R. Scott Budinger, Long Shuang Huang, Satoshi Watanabe, Seok Jo Kim, Nikita Joshi, Viswanathan Natarajan, David W. Kamp, Anantha Harijith, Monica Chi, Anjana V. Yeldandi, Anna P. Lam, Ziyan Lu, Cara J. Gottardi, Paul Cheresh, Kinola J.N. Williams, Alexander V. Misharin
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 5595, p 5595 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 16
International Journal of Molecular Sciences
Volume 21
Issue 16
Idiopathic pulmonary fibrosis (IPF) is a chronic disease for which novel approaches are urgently required. We reported increased sphingosine kinase 1 (SPHK1) in IPF lungs and that SPHK1 inhibition using genetic and pharmacologic approaches reduces mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe3e2ec9e34588a1a9e4989f00e5333
https://www.mdpi.com/1422-0067/21/16/5595
https://www.mdpi.com/1422-0067/21/16/5595