Shed EBA-175 mediates red blood cell clustering that enhances malaria parasite growth and enables immune evasion

Autor: May M Paing, Nichole D Salinas, Yvonne Adams, Anna Oksman, Anja TR Jensen, Daniel E Goldberg, Niraj H Tolia

Publikováno v: eLife, Vol 7 (2018)

Erythrocyte Binding Antigen of 175 kDa (EBA-175) has a well-defined role in binding to glycophorin A (GpA) during Plasmodium falciparum invasion of erythrocytes. However, EBA-175 is shed post invasion and a role for this shed protein has not been def

Externí odkaz: https://doaj.org/article/0b9e9aa91f4f44c7a8316cff9ae63c1a

Author response: Shed EBA-175 mediates red blood cell clustering that enhances malaria parasite growth and enables immune evasion

Autor: May M. Paing, Yvonne Adams, Anna Oksman, Anja T. R. Jensen, Niraj H. Tolia, Nichole D. Salinas, Daniel E. Goldberg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26f08554553e39ade979bb6b7ba96a96
https://doi.org/10.7554/elife.43224.016

Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion

Autor: Svetlana Glushakova, Anna Oksman, Armiyaw S. Nasamu, Ilaria Russo, Arthur S. Kim, Joshua Zimmerberg, Daniel E. Goldberg, Barbara A. Vaupel, Niraj H. Tolia, Marvin J. Meyers, Jacquin C. Niles, Daved H. Fremont, Josh R. Beck

Publikováno v: ResearcherID
Nasamu, A S, Glushakova, S, Russo, I, Vaupel, B, Oksman, A, Kim, A S, Fremont, D H, Tolia, N, Beck, J R, Meyers, M J, Niles, J C, Zimmerberg, J & Goldberg, D E 2017, ' Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion ', Science, vol. 358, no. 6362, pp. 518-522 . https://doi.org/10.1126/science.aan1478

Plasmodium parasite entrance and exit Sweats and fever are the hallmarks of malaria. Red blood cells are the replication factories for malaria parasites. Fever occurs when the parasites' merozoite stages burst en masse from red blood cells into the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96328415a85e8502e134fd2fbaf30f1
https://europepmc.org/articles/PMC5928414/

New benzimidazole derivatives as antiplasmodial agents and plasmepsin inhibitors: Synthesis and analysis of structure–activity relationships

Autor: Waseem Ahmad, Arfa Akram, Shamim Akhtar, Anna Oksman, Arshad Arayne, Shaheen A Hussain, Zafar Saied Saify, Daniel E. Goldberg, M. Kamran Azim, Ishtiaq Ahmad Khan, Mehrun Nisa

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 22:1282-1286

The newly synthesized benzimidazole compounds were suggested to be inhibitors of Plasmodium falciparum plasmepsin II and human cathepsin D by virtual screening of an internal library of synthetic compounds. This was confirmed by enzyme inhibition stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f29130cef76b1521d614ee6b57ae3d
https://doi.org/10.1016/j.bmcl.2011.10.018

Fatty acid acylation regulates trafficking of the unusual Plasmodium falciparum calpain to the nucleolus

Autor: Anna Oksman, Ilaria Russo, Daniel E. Goldberg

Publikováno v: Molecular Microbiology. 72:229-245

The Plasmodium falciparum genome encodes a single calpain. By generating P. falciparum clones expressing C-terminally tagged calpain, we localized this protein to the nucleolus. Pf_calpain possesses an unusual and long N-terminal domain in which we i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54d2d003524f68076a11e72e8ea9fab2
https://doi.org/10.1111/j.1365-2958.2009.06639.x