Výsledky vyhledávání - "Anna Nieborak"

Akademický článek

Depletion of pyruvate kinase (PK) activity causes glycolytic intermediate imbalances and reveals a PK-TXNIP regulatory axis

Autor: Anna Nieborak, Saulius Lukauskas, Jordi Capellades, Patricia Heyn, Gabriela Silva Santos, Karsten Motzler, Anja Zeigerer, Romina Bester, Ulrike Protzer, Florian Schelter, Mirko Wagner, Thomas Carell, Alexander Hruscha, Bettina Schmid, Oscar Yanes, Robert Schneider

Publikováno v: Molecular Metabolism, Vol 74, Iss , Pp 101748- (2023)

Objective: Cancer cells convert more glucose into lactate than healthy cells, what contributes to their growth advantage. Pyruvate kinase (PK) is a key rate limiting enzyme in this process, what makes it a promising potential therapeutic target. Howe

Externí odkaz: https://doaj.org/article/1cdb8cc6c3104464995700a9b14eb2eb

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Akademický článek

Metabolic intermediates – Cellular messengers talking to chromatin modifiers

Autor: Anna Nieborak, Robert Schneider

Publikováno v: Molecular Metabolism, Vol 14, Iss , Pp 39-52 (2018)

Background: To maintain homeostasis, cells need to coordinate the expression of their genes. Epigenetic mechanisms controlling transcription activation and repression include DNA methylation and post-translational modifications of histones, which can

Externí odkaz: https://doaj.org/article/358f0a6af7684006817fd1f5c717b965

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Significance of the pathogenic mutation T372R in the Yin Yang 1 protein interaction with DNA - thermodynamic studies

Autor: Andrzej Górecki, Anna Nieborak

Publikováno v: FEBS Letters. 590:838-847

This work focuses on the pathogenic missense mutation in YY1 protein correlated with insulinomas. Based on in vitro studies, we demonstrate that the mutation does not affect the secondary structure of either zinc fingers or the N-terminal fragment (N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b73f287d8139bfb6202d0986859a23
https://doi.org/10.1002/1873-3468.12106

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Histone propionylation is a mark of active chromatin

Autor: Raphaël Margueron, Robert H. Schneider, Aaron Taudt, Anna Nieborak, Florian Richter, Marijke P. Baltissen, Helena de Fatima Magliarelli, Gergö Meszaros, Maria Colomé-Tatché, Sylvain Daujat, Michiel Vermeulen, Lara Zorro Shahidian, Stéphanie Le Gras, Gerhard Mittler, Diana Aguilar Gómez, Adam Fiseha Kebede, Romeo Ricci

Publikováno v: Nature Structural & Molecular Biology, 24, 12, pp. 1048-1062
Nature Structural & Molecular Biology, 24(12), 1048-1056. Nature Publishing Group
Nature Structural & Molecular Biology, 24, 1048-1062

Histones are highly covalently modified, but the functions of many of these modifications remain unknown. In particular, it is unclear how histone marks are coupled to cellular metabolism and how this coupling affects chromatin architecture. We ident

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6776958a02e47f0e3f4215a2e9338aa
https://hdl.handle.net/2066/207705

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