Evaluation of emodepside in laboratory models of human intestinal nematode and schistosome infections

Autor: Tanja Karpstein, Valérian Pasche, Cécile Häberli, Ivan Scandale, Anna Neodo, Jennifer Keiser

Publikováno v: Parasites & Vectors, Vol 12, Iss 1, Pp 1-10 (2019)

Abstract Background Helminthiases are very prevalent worldwide, yet their treatment and control rely on a handful of drugs. Emodepside, a marketed broad-spectrum veterinary anthelminthic with a unique mechanism of action, undergoing development for o

Externí odkaz: https://doaj.org/article/bb2098fcab2145fa80878d0aa1e09c3c

Evaluation of emodepside in laboratory models of human intestinal nematode and schistosome infections

Autor: Cécile Häberli, Ivan Scandale, Anna Neodo, Valérian Pasche, Tanja Karpstein, Jennifer Keiser

Publikováno v: Parasites & Vectors, Vol 12, Iss 1, Pp 1-10 (2019)
Parasites & Vectors

Background Helminthiases are very prevalent worldwide, yet their treatment and control rely on a handful of drugs. Emodepside, a marketed broad-spectrum veterinary anthelminthic with a unique mechanism of action, undergoing development for onchocerci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0a73a301959b65fc4ac6ac8476a609
http://link.springer.com/article/10.1186/s13071-019-3476-x

Population Pharmacokinetics and Exposure-Response Analysis of Tribendimidine To Improve Treatment for Children with Hookworm Infection

Autor: Janneke M. Brussee, Marc Pfister, Jennifer Keiser, Noemi Hiroshige, Anna Neodo, Jean T. Coulibaly

Publikováno v: Antimicrob Agents Chemother

Tribendimidine has been successful in treating hookworm infections and may serve as an alternative to albendazole should resistance arise. Our aims were to (i) characterize the pharmacokinetics (PK) of tribendimidine’s primary metabolite, deacetyla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5c8abea7ab8f7237197c4aa93884e03
https://doi.org/10.1128/aac.01778-20

Exposure of Heligmosomoides polygyrus and Trichuris muris to albendazole, albendazole sulfoxide, mebendazole and oxantel pamoate in vitro and in vivo to elucidate the pathway of drug entry into these gastrointestinal nematodes

Autor: Jennifer Keiser, Anna Neodo, Noemi Cowan, Charles Meier

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 7, Iss 2, Pp 159-173 (2017)
International Journal for Parasitology: Drugs and Drug Resistance

Millions of people are treated with anthelmintics to control soil-transmitted helminth infections; yet, drug distribution in the plasma and gastrointestinal tract compartments and the pathway of drug uptake into gastrointestinal nematodes responsible

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df67d83c1c9340eff078ab34913d7b9c
http://www.sciencedirect.com/science/article/pii/S2211320716301348

In Vitro and In Vivo Drug-Drug Interaction Study of the Effects of Ivermectin and Oxantel Pamoate on Tribendimidine

Autor: Jennifer Keiser, Jessica D. Schulz, Anna Neodo, Jörg Huwyler

Publikováno v: Antimicrobial Agents and Chemotherapy. 63

Soil-transmitted helminth (STH) infections still remain a major health problem in poor rural settings. The lack of efficacious drugs against all STH species raises interest in drug combinations. Drug-drug interactions (DDIs) are, however, of major co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ef8f225d06098b5d7b70d709f13a19
https://doi.org/10.1128/aac.00762-18