Výsledky vyhledávání - "Anna N. Mendler"

Akademický článek

Double Strike Approach for Tumor Attack: Engineering T Cells Using a CD40L:CD28 Chimeric Co-Stimulatory Switch Protein for Enhanced Tumor Targeting in Adoptive Cell Therapy

Autor: Luis Felipe Olguín-Contreras, Anna N. Mendler, Grzegorz Popowicz, Bin Hu, Elfriede Noessner

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Activation of co-stimulatory pathways in cytotoxic T lymphocytes expressing chimeric antigen receptors (CARs) have proven to boost effector activity, tumor rejection and long-term T cell persistence. When using antigen-specific T cell receptors (TCR)

Externí odkaz: https://doaj.org/article/0de3501e8ca94ab1bedcd6a7f66b7639

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Akademický článek

Tumor Lactic Acidosis: Protecting Tumor by Inhibiting Cytotoxic Activity Through Motility Arrest and Bioenergetic Silencing

Autor: Angelika J. Fischbeck, Svenja Ruehland, Andreas Ettinger, Kerstin Paetzold, Ilias Masouris, Elfriede Noessner, Anna N. Mendler

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

Adoptive T cell therapy (ACT) is highly effective in the treatment of hematologic malignancies, but shows limited success in solid tumors. Inactivation of T cells in the tumor milieu is a major hurdle to a wider application of ACT. Cytotoxicity is th

Externí odkaz: https://doaj.org/article/302c86f4e7e749b2b3d6b3da0510006d

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NK-cell dysfunction in human renal carcinoma reveals diacylglycerol kinase as key regulator and target for therapeutic intervention

Autor: Elfriede Noessner, Ralph Oberneder, Dorothee Brech, Anna N. Mendler, Petra U. Prinz, Ilias Masouris

Publikováno v: International Journal of Cancer. 135:1832-1841

The relevance of NK cells in tumor control is well established in mouse models and human hematologic malignancies; however, their contribution to the control of human solid tumors remains disputed due to problems with in situ detection and reports of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d276ec06800f359d6b483a0d450bd2d
https://doi.org/10.1002/ijc.28837

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A novel CXCL10-based GPI-anchored fusion protein as adjuvant in NK-based tumor therapy

Autor: Laura Hinz, Niklas Muenchmeier, Nicole Rieth, Sophia Boecker, Peter J. Nelson, Elfriede Noessner, Anna N. Mendler, Lorenz Bankel, Constantin Lapa, Ralph Mocikat

Publikováno v: PLoS ONE 8:e72749 (2013)
PLoS ONE, Vol 8, Iss 8, p e72749 (2013)
PLoS ONE

Background Cellular therapy is a promising therapeutic strategy for malignant diseases. The efficacy of this therapy can be limited by poor infiltration of the tumor by immune effector cells. In particular, NK cell infiltration is often reduced relat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf2a98d899d7984ad7ae33146498458
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=27373

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Progressive natural killer cell dysfunction associated with alterations in subset proportions and receptor expression in soft-tissue sarcoma patients

Autor: Rolf D. Issels, Jan C. Schmollinger, Marion Subklewe, Tina Adunka, Anna N. Mendler, Veit Bücklein, Elfriede Noessner

Publikováno v: Oncoimmunology
OncoImmunology 5:e1178421 (2016)

Immunotherapy is currently investigated as treatment option in many types of cancer. So far, results from clinical trials have demonstrated that significant benefit from immunomodulatory therapies is restricted to patients with select histologies. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77480e8af7813f6e3df76602e13d5c06
https://doi.org/10.1080/2162402x.2016.1178421

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High DGK-α and disabled MAPK pathways cause dysfunction of human tumor-infiltrating CD8+ T cells that is reversible by pharmacologic intervention

Autor: Ilias Masouris, Petra U. Prinz, Elfriede Noessner, Ralph Oberneder, Leopold Durner, Anna N. Mendler

Publikováno v: J. Immunol. 188, 5990-6000 (2012)

CD8+ tumor-infiltrating T cells (CD8-TILs) are found in many types of tumors including human renal cell carcinoma. However, tumor rejection rarely occurs, suggesting limited functional activity in the tumor microenvironment. In this study, we documen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04844889c4e3eb63670dfef6f239a6e
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=7569

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Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation

Autor: Marina Kreutz, Elfriede Noessner, Petra U. Prinz, Eva Gottfried, Anna N. Mendler, Bin Hu

Publikováno v: Int. J. Cancer 131, 633-640 (2012)

Lactic acidosis is common to most solid tumors and has been found to affect infiltrating immune cells. Here we document effector phase inhibition of cytotoxic T cells (CTLs) involving complete blockage of cytokine production and partial impairment of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cefd153805d1019176259544d6f1180
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=6619

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Akademický článek

A novel CXCL10-based GPI-anchored fusion protein as adjuvant in NK-based tumor therapy.

Autor: Niklas Muenchmeier, Sophia Boecker, Lorenz Bankel, Laura Hinz, Nicole Rieth, Constantin Lapa, Anna N Mendler, Elfriede Noessner, Ralph Mocikat, Peter J Nelson

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e72749 (2013)

BACKGROUND: Cellular therapy is a promising therapeutic strategy for malignant diseases. The efficacy of this therapy can be limited by poor infiltration of the tumor by immune effector cells. In particular, NK cell infiltration is often reduced rela

Externí odkaz: https://doaj.org/article/a767ad6f616b48279f2d0cdeb9ac8030

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