Výsledky vyhledávání - "Anna Murphree"

Crystallographic Location and Mutational Analysis of Zn and Cd Inhibitory Sites and Role of Lipidic Carboxylates in Rescuing Proton Path Mutants in Cytochrome c Oxidase

Autor: Denise A. Mills, Carrie Hiser, R. Michael Garavito, Jonathan P. Hosler, Ling Qin, Shelagh Ferguson-Miller, Anna Murphree

Publikováno v: Biochemistry. 46:6239-6248

Cytochrome c oxidase (CcO) transfers protons from the inner surface of the enzyme to the buried O2 reduction site through two different pathways, termed K and D, and from the outer surface via an undefined route. These proton paths can be inhibited b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68facd96fb7a0eaf42d5ee06522b269c
https://doi.org/10.1021/bi700173w

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Altering Conserved Lipid Binding Sites in Cytochrome c Oxidase of Rhodobacter sphaeroides Perturbs the Interaction between Subunits I and III and Promotes Suicide Inactivation of the Enzyme

Autor: Rodney C. Baker, Denise A. Mills, Jimmy Gray, Jonathan P. Hosler, Chris Purser, Lakshman Varanasi, Anna Murphree

Publikováno v: Biochemistry. 45:14896-14907

Subunit III of the three-subunit catalytic core of cytochrome c oxidase (CcO) contains no metal centers, but it does bind two lipids, within a deep cleft, in binding sites conserved from bacteria to humans. Subunit III binds to subunit I, where it pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5b3982b6200f95297b2be248b673f3
https://doi.org/10.1021/bi061390q

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