Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Anna Motterle"'
Autor:
Anna Motterle, Sonia Gattesco, Marie-Line Peyot, Jonathan Lou S. Esguerra, Ana Gomez-Ruiz, D. Ross Laybutt, Patrick Gilon, Frédéric Burdet, Mark Ibberson, Lena Eliasson, Marc Prentki, Romano Regazzi
Publikováno v:
Molecular Metabolism, Vol 6, Iss 11, Pp 1407-1418 (2017)
Objective: Non-coding RNAs constitute a major fraction of the β-cell transcriptome. While the involvement of microRNAs is well established, the contribution of long non-coding RNAs (lncRNAs) in the regulation of β-cell functions and in diabetes dev
Externí odkaz:
https://doaj.org/article/3b8e45242e6146db91dafa93326fa629
Autor:
Veronika Souslova, Paul A Townsend, Jelena Mann, Chris M van der Loos, Anna Motterle, Fulvio D'Acquisto, Derek A Mann, Shu Ye
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9902 (2010)
Matrix metalloproteinase-3 (MMP3) is implicated in the pathogenesis and progression of atherosclerotic lesions. Previous studies suggested that MMP3 expression is influenced by a polymorphism (known as the 5A/6A polymorphism) in the promoter of the M
Externí odkaz:
https://doaj.org/article/f2b8d3a6e3994059a806ef88ada8a1f6
Autor:
Romano Regazzi, Ana Gómez-Ruiz, Frédéric Burdet, Marc Prentki, Patrick Gilon, Mark Ibberson, Sonia Gattesco, Jonathan L.S. Esguerra, Lena Eliasson, D. Ross Laybutt, Anna Motterle, Marie-Line Peyot
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 6, Iss 11, Pp 1407-1418 (2017)
Molecular metabolism, vol. 6, no. 11, pp. 1407-1418
Molecular Metabolism, Vol. 6, p. 1407-1418 (2017)
Molecular Metabolism, Vol 6, Iss 11, Pp 1407-1418 (2017)
Molecular metabolism, vol. 6, no. 11, pp. 1407-1418
Molecular Metabolism, Vol. 6, p. 1407-1418 (2017)
Objective Non-coding RNAs constitute a major fraction of the β-cell transcriptome. While the involvement of microRNAs is well established, the contribution of long non-coding RNAs (lncRNAs) in the regulation of β-cell functions and in diabetes deve
Publikováno v:
Diabetes, Obesity and Metabolism. 18:41-50
Pancreatic β-cells are highly specialized cells committed to secrete insulin in response to changes in the level of nutrients, hormones and neurotransmitters. Chronic exposure to elevated concentrations of glucose, fatty acids or inflammatory mediat
Involvement of long non-coding RNAs in beta cell failure at the onset of type 1 diabetes in NOD mice
Publikováno v:
DIABETOLOGIA
Diabetologia, vol. 58, no. 8, pp. 1827-1835
Diabetologia, vol. 58, no. 8, pp. 1827-1835
AIMS/HYPOTHESIS: Exposure of pancreatic beta cells to cytokines released by islet-infiltrating immune cells induces alterations in gene expression, leading to impaired insulin secretion and apoptosis in the initial phases of type 1 diabetes. Long non
Autor:
Beski Shohreh, Xiangyuan Pu, Shivani Gor, Kenneth Chan, Shu Ye, Fu Liang Ng, Qingzhong Xiao, Frank Cross, Arthur Tucker, Mark J. Caulfield, Robin N. Poston, Anna Motterle, Harriet Wood
Publikováno v:
Human Molecular Genetics. 21:4021-4029
Variation on chromosome 9p21 is associated with risk of coronary artery disease (CAD). This genomic region contains the CDKN2A and CDKN2B genes which encode the cell cycle regulators p16(INK4a), p14(ARF) and p15(INK4b) and the ANRIL gene which encode
Autor:
Anna Motterle, Shu Ye, G.E. Morris, Stefan Kiechl, Mark J. Caulfield, Johann Willeit, Qingzhong Xiao, Sylvia L.F. Pender
Publikováno v:
Atherosclerosis. 220:351-354
In vitro studies have shown that matrix metalloproteinase-12 (MMP12) can degrade fibrinogen, a clotting factor whose level predicts risk of advanced atherosclerosis and myocardial infarction. In this study, we found that mean plasma fibrinogen level
Publikováno v:
Diabetes obesity & metabolism
Pancreatic β-cells play a central role in glucose homeostasis by tightly regulating insulin release according to the organism's demand. Impairment of β-cell function due to hostile environment, such as hyperglycaemia and hyperlipidaemia, or due to
Autor:
Shu Ye, Anna Motterle, Stefan Kiechl, Qingzhong Xiao, Friedrich Oberhollenzer, Ross C. Laxton, Johann Willeit, Qingbo Xu
Publikováno v:
Atherosclerosis. 208:451-455
Recent studies have revealed that sequence variation on chromosome 9p21 is a major genetic determinant for coronary heart disease and stroke, however, the underlying mechanism remains unknown. This genomic region contains the gene encoding cyclin-dep
Autor:
Richard E. Peterson, Aibin He, William T. Pu, Samir Ounzain, Satoru Kobayashi, Donald R. Menick, Qiangrong Liang, Nilesh J. Samani, Anna Motterle, Nelson W. Chong
Publikováno v:
Molecular and cellular biology. 32(10)
Ms1/STARS is a novel muscle-specific actin-binding protein that specifically modulates the myocardin-related transcription factor (MRTF)-serum response factor (SRF) regulatory axis within striated muscle. This ms1/STARS-dependent regulatory axis is o