Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Anna Memou"'
Autor:
Nicole Comfort, Meethila Gade, Madeleine Strait, Samantha J. Merwin, Daphne Antoniou, Chiara Parodi, Lina Marcinczyk, Lea Jean‐Francois, Tessa R. Bloomquist, Anna Memou, Hardy J. Rideout, Stefania Corti, Shingo Kariya, Diane B. Re
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 3, Pp 1322-1336 (2023)
Abstract Background Sarcopenia, the age‐associated decline in skeletal muscle mass and strength, has long been considered a disease of muscle only, but accumulating evidence suggests that sarcopenia could originate from the neural components contro
Externí odkaz:
https://doaj.org/article/971c856039ca453e86c53bf33c9ab51e
Autor:
Nasia Antoniou, Dimitrios Vlachakis, Anna Memou, Emmanouela Leandrou, Polytimi-Eleni Valkimadi, Katerina Melachroinou, Diane B. Re, Serge Przedborski, William T. Dauer, Leonidas Stefanis, Hardy J. Rideout
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Abstract In experimental models, both in vivo and cellular, over-expression of Parkinson’s linked mutant leucine-rich repeat kinase 2 (LRRK2) is sufficient to induce neuronal death. While several cell death associated proteins have been linked to L
Externí odkaz:
https://doaj.org/article/023f75cba7e141e794a505571ddc8b16
Autor:
Katerina Melachroinou, Emmanouela Leandrou, Polytimi-Eleni Valkimadi, Anna Memou, Georgios Hadjigeorgiou, Leonidas Stefanis, Hardy J Rideout
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166053 (2016)
Despite the plethora of sequence variants in LRRK2, only a few clearly segregate with PD. Even within this group of pathogenic mutations, the phenotypic profile can differ widely.We examined multiple properties of LRRK2 behavior in cellular models ov
Externí odkaz:
https://doaj.org/article/ed751423893843bfb4c676d2114bec17
Autor:
Nicole Comfort, Meethila Gade, Madeleine Strait, Samantha J. Merwin, Daphne Antoniou, Anna Memou, Hardy J. Rideout, Stefania Corti, Shingo Kariya, Diane B. Re
BackgroundSarcopenia, the age-associated decline in skeletal muscle mass and strength, has long been considered a disease of muscle only, but accumulating evidence suggests that sarcopenia could originate from the neural components controlling muscle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dc225c8f92d9569560431276fe7540d
https://doi.org/10.1101/2022.02.01.478571
https://doi.org/10.1101/2022.02.01.478571
Autor:
Emmanouela Leandrou, Nicolina Clemente, Adam Schaffner, Iban Ubarretxena-Belandia, Chen Yao, Zhenyu Yue, Xiaoluan Hua, Lianteng Zhi, Hui Zhang, Christopher J. H. Elliott, Nina Pan, Shu G. Chen, Xianting Li, Hardy J. Rideout, Anna Memou, Ming-Ming Zhou, Farinaz Afsari, Keita Morohashi, Yacob Gomez-Llorente, Chunyu Wang
Publikováno v:
Cell Research. 29:313-329
Missense mutations in Leucine-Rich Repeat Kinase 2 (LRRK2) cause the majority of familial and some sporadic forms of Parkinson's disease (PD). The hyperactivity of LRRK2 kinase induced by the pathogenic mutations underlies neurotoxicity, promoting th
Autor:
Maria Kedariti, Andriana Lamprou, Michalis Kentros, Anna Memou, Lilian Petropoulou-Vathi, Polytimi-Eleni Valkimadi, Lampros Dimitrakopoulos, Hardy J. Rideout
Publikováno v:
Brain research. 1771
Parkinson's disease (PD) is the second most common neurodegenerative disease, comprised of both familial and idiopathic forms, behind only Alzheimer's disease (AD). The disease is characterized, regardless of the pathogenesis, primarily by a loss of
P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity
Autor:
Marc Bolliger, Anna Memou, Hardy J. Rideout, Alexia F. Kalogeropulou, William H. Wilson, Jing Zhao, R. Jeremy Nichols, Tyler P. Molitor, Shreya Narasimha
Publikováno v:
Biochemical Journal. 475:1271-1293
Autosomal-dominant, missense mutations in the leucine-rich repeat protein kinase 2 (LRRK2) gene are the most common genetic predisposition to develop Parkinson's disease (PD). LRRK2 kinase activity is increased in several pathogenic mutations (N1437H
Autor:
Emmanouela Leandrou, Katerina Melachroinou, Eliana Markidi, Elisa Greggio, Hardy J. Rideout, Anna Memou
The Parkinson's disease (PD) protein leucine-rich repeat kinase 2 (LRRK2) exists as a mixture of monomeric and dimeric species, with its kinase activity highly concentrated in the dimeric conformation of the enzyme. We have adapted the proximity biot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b687816fcc3d51df09b8af62568a5ca
http://hdl.handle.net/11577/3309713
http://hdl.handle.net/11577/3309713