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Akademický článek

Do Long-Acting Injectable Antipsychotics Influence Serum Levels of Brain-Derived Neurotrophic Factor in People With Schizophrenia and Schizoaffective Disorder?

Publikováno v: Mental Illness, Vol 2024 (2024)

Schizophrenia (SCZ) and schizoaffective disorder (SAD) are severe and complex psychiatric disorders whose liability threshold is modulated by the interplay of biological, mainly genetic, and environmental factors. Consistent evidence has pointed to t

Externí odkaz: https://doaj.org/article/f67ca0f413e444469a23236b54af506a

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Akademický článek

Analysis on in vitro effect of lithium on telomere length in lymphoblastoid cell lines from bipolar disorder patients with different clinical response to long-term lithium treatment

Autor: Alessio Squassina, Anna Meloni, Donatella Congiu, Panagiotis Bosganas, George P. Patrinos, Rixing Lin, Gustavo Turecki, Giovanni Severino, Raffaella Ardau, Caterina Chillotti, Claudia Pisanu

Publikováno v: Human Genomics, Vol 16, Iss 1, Pp 1-7 (2022)

Abstract Background It has been suggested that bipolar disorder (BD) is associated with clinical and biological features of accelerated aging. In our previous studies, we showed that long-term lithium treatment was correlated with longer leukocyte te

Externí odkaz: https://doaj.org/article/ec7d29fa1b5d4fe98acbe22cdd4d6ef3

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Akademický článek

Probing the Association between Cognition, Suicidal Behavior and Tryptophan Metabolism in a Sample of Individuals Living with Bipolar Disorder: A Secondary Analysis

Publikováno v: Brain Sciences, Vol 13, Iss 4, p 693 (2023)

Background and Objectives: Alterations in hot cognition and in the tryptophan metabolism through serotonin (5-HT) and kynurenine (KYN) pathways have been associated with an increased risk of suicidal behavior. Here, we aim at probing the association

Externí odkaz: https://doaj.org/article/2a9577058629418a92190c06341799c5

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Akademický článek

Exploring the association between brain-derived neurotrophic factor levels and longitudinal psychopathological and cognitive changes in Sardinian psychotic patients

Publikováno v: European Psychiatry, Vol 65 (2022)

Abstract Background and hypothesis Schizophrenia spectrum disorders are among the most debilitating mental disorders and has complex pathophysiological underpinnings. There is growing evidence that brain-derived neurotrophic factor (BDNF) can play a

Externí odkaz: https://doaj.org/article/c68ae7193fcd44d5a6f575944b516de9

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Akademický článek

Converging Evidence Points to BDNF as Biomarker of Depressive Symptoms in Schizophrenia-Spectrum Disorders

Publikováno v: Brain Sciences, Vol 12, Iss 12, p 1666 (2022)

Brain-derived neurotrophic factor (BDNF) is a key modulator of neuroplasticity and has an important role in determining the susceptibility to severe psychiatric disorder with a significant neurodevelopmental component such as major psychoses. Indeed,

Externí odkaz: https://doaj.org/article/2ca50f1dcede47ec89f23c23b5164ee3

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Akademický článek

Investigation of Genetic Variants Associated with Tryptophan Metabolite Levels via Serotonin and Kynurenine Pathways in Patients with Bipolar Disorder

Publikováno v: Metabolites, Vol 12, Iss 11, p 1127 (2022)

The kynurenine pathway (KP) may play a role in the pathophysiology of bipolar disorder (BD). We conducted a genome-wide association study (GWAS) to identify genetic variants associated with the plasma levels of the metabolites of tryptophan (TRP) via

Externí odkaz: https://doaj.org/article/5861d6e5720f4fc6b9ffb742f93b32f1

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Protocol for a pharmacogenetic study of antidepressants: characterization of drug-metabolizing profiles of cytochromes CYP2D6 and CYP2C19 in a Sardinian population of patients with major depressive disorder

Autor: Francesco Mola, A. Carta, Anna Meloni, Alessio Squassina, Pasquale Paribello, Bernardo Carpiniello, Maria Del Zompo, Claudia Pisanu, Marco Pinna, Mirko Manchia, Claudio Conversano, Federica Pinna

Publikováno v: Psychiatric Genetics. 31:186-193

The effectiveness of antidepressants shows high interindividual variability ranging from full symptomatologic remission to treatment-resistant depression. Many factors can determine the variation in the clinical response, but a fundamental role is pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66c45968a388a7006b75f5da613ffd8
https://doi.org/10.1097/ypg.0000000000000293

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Cost-Utility Analysis of Pharmacogenetic Testing Based on CYP2C19 or CYP2D6 in Major Depressive Disorder: Assessing the Drivers of Different Cost-Effectiveness Levels from an Italian Societal Perspective

Autor: Andrea Carta, Maria Del Zompo, Anna Meloni, Francesco Mola, Pasquale Paribello, Federica Pinna, Marco Pinna, Claudia Pisanu, Mirko Manchia, Alessio Squassina, Bernardo Carpiniello, Claudio Conversano

Publikováno v: Clinical drug investigation. 42(9)

Major depressive disorder (MDD) is a common and severe psychiatric disorder that has enormous economical and societal costs. As pharmacogenetics is one of the key tools of precision psychiatry, we analyze the cost-utility of test screening of CYP2C19

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ffa6e3e21e2980611e2981c2087b81f
https://pubmed.ncbi.nlm.nih.gov/35930170

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