Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Anna Meljon"'
Autor:
Anna Meljon, Peter J. Crick, Eylan Yutuc, Joyce L. Yau, Jonathan R. Seckl, Spyridon Theofilopoulos, Ernest Arenas, Yuqin Wang, William J. Griffiths
Publikováno v:
Biomolecules, Vol 9, Iss 4, p 149 (2019)
Deficiency in cytochrome P450 (CYP) 7B1, also known as oxysterol 7α-hydroxylase, in humans leads to hereditary spastic paraplegia type 5 (SPG5) and in some cases in infants to liver disease. SPG5 is medically characterized by loss of motor neurons i
Externí odkaz:
https://doaj.org/article/848a439f0557428f8a7a0f9ecc731797
Autor:
Anna Meljon, Spyridon Theofilopoulos, Cedric H.L. Shackleton, Gordon L. Watson, Norman B. Javitt, Hans-Joachim Knölker, Ratni Saini, Ernest Arenas, Yuqin Wang, William J. Griffiths
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 11, Pp 2469-2483 (2012)
Unesterified cholesterol is a major component of plasma membranes. In the brain of the adult, it is mostly found in myelin sheaths, where it plays a major architectural role. In the newborn mouse, little myelination of neurons has occurred, and much
Externí odkaz:
https://doaj.org/article/a741b3827125454fb17d6fdba5a7cf6b
The development of suitable analytical tools is required to study the stability, manufacturability and bio-performance of peptide conjugate therapeutics. Mass spectrometric analysis provides essential knowledge for understanding and building the crit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a928da10c0166efb3a8f1ff41f83e16
https://doi.org/10.1039/9781788016445-00343
https://doi.org/10.1039/9781788016445-00343
Publikováno v:
Mass Spectrometry Handbook
Publikováno v:
Biochemical pharmacology. 86(1)
In this study the sterol and oxysterol profile of newborn brain from the Dhcr7(Δ3-5/T93M) mouse model of Smith-Lemli-Opitz syndrome (SLOS) has been investigated. This is a viable mouse model which is compound heterozygous containing one null allele
Autor:
Zsolts Ruzsics, Paul Lacaze, Mathieu Blanc, Anna Meljon, Nathanael J. Spann, Jürgen Haas, Marie Craigon, Guanghou Shui, Kai A. Kropp, Steven Watterson, Kathiresan Krishnan, William J. Griffiths, Thorsten Forster, Markus R. Wenk, Simon G. Talbot, Christopher K. Glass, Wei Yuan Hsieh, Ana Angulo, Yuqin Wang, Kevin A. Robertson, Peter Ghazal, Douglas F. Covey, Samantha J. Griffiths
Publikováno v:
Blanc, M, Hsieh, W Y, Robertson, K A, Kropp, K A, Forster, T, Shui, G, Lacaze, P, Watterson, S, Griffiths, S J, Spann, N J, Meljon, A, Talbot, S, Krishnan, K, Covey, D F, Wenk, M R, Craigon, M, Ruzsics, Z, Haas, J, Angulo, A, Griffiths, W J, Glass, C K, Wang, Y & Ghazal, P 2013, ' The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response ', Immunity, vol. 38, no. 1, pp. 106–118 . https://doi.org/10.1016/j.immuni.2012.11.004
Immunity
Immunity
Summary Recent studies suggest that the sterol metabolic network participates in the interferon (IFN) antiviral response. However, the molecular mechanisms linking IFN with the sterol network and the identity of sterol mediators remain unknown. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35cb39676fc00f1322712916051e592b
https://www.pure.ed.ac.uk/ws/files/8197918/The_Transcription_Factor_STAT_1_Couples_Macrophage_Synthesis_of_25_Hydroxycholesterol_to_the_Interferon_Antiviral_Response.pdf
https://www.pure.ed.ac.uk/ws/files/8197918/The_Transcription_Factor_STAT_1_Couples_Macrophage_Synthesis_of_25_Hydroxycholesterol_to_the_Interferon_Antiviral_Response.pdf
Autor:
Hans-Joachim Knölker, William J. Griffiths, Arndt W. Schmidt, Ratni Saini, Yuqin Wang, Olga Kataeva, Anna Meljon
Using 3β-hydroxychol-5-en-24-oic acid (4) as starting material, the diastereoisomeric allylic alcohols (24E)-26-hydroxydesmosterol (2) and (24Z)-26-hydroxydesmosterol (3) have been synthesised in six steps with 67% and 12% overall yield, respectivel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a28e02e46e2cace91ba509133be40c3
https://cronfa.swan.ac.uk/Record/cronfa15364
https://cronfa.swan.ac.uk/Record/cronfa15364
Publikováno v:
FEBS Letters. (3):205-208
It has been shown that the incorporation of [14C]serine into phosphatidylserine (PS) in isolated rat liver nuclei is intrinsic to this organelle as attested by marker enzyme activity. Serine incorporation into PS was the highest in nuclei depleted of