Combined intramuscular and intraspinal transplant of bone marrow cells improves neuromuscular function in the SOD1G93A mice

Autor: Anna Martínez-Muriana, Diego Pastor, Renzo Mancuso, Amaya Rando, Rosario Osta, Salvador Martínez, Rubèn López-Vales, Xavier Navarro

Publikováno v: Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-11 (2020)

Abstract Background The simultaneous contribution of several etiopathogenic disturbances makes amyotrophic lateral sclerosis (ALS) a fatal and challenging disease. Here, we studied two different cell therapy protocols to protect both central and peri

Externí odkaz: https://doaj.org/article/8d33161732da499ba5e50cfa37ffd723

Neuregulin-1 promotes functional improvement by enhancing collateral sprouting in SOD1G93A ALS mice and after partial muscle denervation

Autor: Renzo Mancuso, Anna Martínez-Muriana, Tatiana Leiva, David Gregorio, Lorena Ariza, Marta Morell, Jesús Esteban-Pérez, Alberto García-Redondo, Ana C. Calvo, Gabriela Atencia-Cibreiro, Gabriel Corfas, Rosario Osta, Assumpció Bosch, Xavier Navarro

Publikováno v: Neurobiology of Disease, Vol 95, Iss , Pp 168-178 (2016)

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive degeneration of motoneurons, which is preceded by loss of neuromuscular connections in a “dying back” process. Neuregulin-1 (Nrg1) is a neurotrophic f

Externí odkaz: https://doaj.org/article/c76a86ef64a142899121229bddad684b

Stem-cell-derived human microglia transplanted into mouse brain to study human disease

Autor: Renzo Mancuso, Ivana Geric, Bart De Strooper, Anna Martínez-Muriana, Nicola Fattorelli, Leen Wolfs

Publikováno v: Nature Protocols
Nature protocols

Microglia are critically involved in complex neurological disorders with a strong genetic component, such as Alzheimer's disease, Parkinson's disease and frontotemporal dementia. Although mouse microglia can recapitulate aspects of human microglia ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983d16fd294095dce10610596d721e6a
https://lirias.kuleuven.be/handle/123456789/668199

Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition

Autor: Pierre Lemaitre, Lidia Yshii, Carlos P. Roca, Teresa Prezzemolo, Wenson D. Rajan, Andrew Young, Oliver T. Burton, Alerie Guzman de la Fuente, Carly E. Whyte, Bart De Strooper, Alena Moudra, Aleksandra Brajic, Renzo Mancuso, Adrian Liston, Lubna Kouser, Zsuzsanna Callaerts-Vegh, Denise C. Fitzgerald, Emanuela Pasciuto, Raul Y. Tito, Michelle Naughton, Jeroen Raes, Vasiliki Lagou, James Dooley, Tom Theys, Suresh Poovathingal, Loriana G. Mascali, Anna Martínez-Muriana

Publikováno v: Cell
Pasciuto, E, Burton, O T, Roca, C P, Lagou, V, Rajan, W D, Theys, T, Mancuso, R, Tito, R Y, Kouser, L, Callaerts-Vegh, Z, de la Fuente, A G, Prezzemolo, T, Mascali, L G, Brajic, A, Whyte, C E, Yshii, L, Martinez-Muriana, A, Naughton, M, Young, A, Moudra, A, Lemaitre, P, Poovathingal, S, Raes, J, De Strooper, B, Fitzgerald, D C, Dooley, J & Liston, A 2020, ' Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition ', Cell, vol. 182, no. 3, pp. 625 . https://doi.org/10.1016/j.cell.2020.06.026

The brain is a site of relative immune privilege. Although CD4 T cells have been reported in the central nervous system, their presence in the healthy brain remains controversial, and their function remains largely unknown. We used a combination of i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d8cb0770f5a3db2b4038a0683a729f

IL-4 drives microglia and macrophages toward a phenotype conducive for tissue repair and functional recovery after spinal cord injury

Autor: Jesús Amo-Aparicio, Rubèn López-Vales, Anna Martínez-Muriana, Isaac Francos-Quijorna

Publikováno v: Glia. 64:2079-2092

Macrophages and microglia play a key role in the maintenance of nervous system homeostasis. However, upon different challenges, they can adopt several phenotypes, which may lead to divergent effects on tissue repair. After spinal cord injury (SCI), m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8a20c2867ad7d1dca95e3452acb6fad
https://doi.org/10.1002/glia.23041