Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Anna Marley"'
Autor:
Céline Cruciani-Guglielmacci, Lara Bellini, Jessica Denom, Masaya Oshima, Neïké Fernandez, Priscilla Normandie-Levi, Xavier P. Berney, Nadim Kassis, Claude Rouch, Julien Dairou, Tracy Gorman, David M. Smith, Anna Marley, Robin Liechti, Dmitry Kuznetsov, Leonore Wigger, Frédéric Burdet, Anne-Laure Lefèvre, Isabelle Wehrle, Ingo Uphues, Tobias Hildebrandt, Werner Rust, Catherine Bernard, Alain Ktorza, Guy A. Rutter, Raphael Scharfmann, Ioannis Xenarios, Hervé Le Stunff, Bernard Thorens, Christophe Magnan, Mark Ibberson
Publikováno v:
Molecular Metabolism, Vol 6, Iss 4, Pp 340-351 (2017)
Objective: In type 2 diabetes (T2D), pancreatic β cells become progressively dysfunctional, leading to a decline in insulin secretion over time. In this study, we aimed to identify key genes involved in pancreatic beta cell dysfunction by analyzing
Externí odkaz:
https://doaj.org/article/64a96d3c764e447db5466d3eb59128b0
Autor:
Gao Sun, Gabriela da Silva Xavier, Tracy Gorman, Claire Priest, Antonia Solomou, David J. Hodson, Marc Foretz, Benoit Viollet, Pedro-Luis Herrera, Helen Parker, Frank Reimann, Fiona M. Gribble, Stephanie Migrenne, Christophe Magnan, Anna Marley, Guy A. Rutter
Publikováno v:
Molecular Metabolism, Vol 4, Iss 4, Pp 277-286 (2015)
Aims/Hypothesis: Glucagon release from pancreatic alpha cells is required for normal glucose homoeostasis and is dysregulated in both Type 1 and Type 2 diabetes. The tumour suppressor LKB1 (STK11) and the downstream kinase AMP-activated protein kinas
Externí odkaz:
https://doaj.org/article/4f54fb1ea32f4d228578aa597d3cc524
Autor:
Katherine Macrae, Clare Stretton, Christopher Lipina, Agnieszka Blachnio-Zabielska, Marcin Baranowski, Jan Gorski, Anna Marley, Harinder S. Hundal
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 9, Pp 2366-2378 (2013)
Chronic exposure of skeletal muscle to saturated fatty acids, such as palmitate (C16:0), enhances proinflammatory IKK-NFκB signaling by a mechanism involving the MAP kinase (Raf-MEK-ERK) pathway. Raf activation can be induced by its dissociation fro
Externí odkaz:
https://doaj.org/article/9e61b45a61e84b389bc5eee7a75ee2ca
Autor:
Ola Fjellström, Niklas Larsson, Shin-Ichiro Yasuda, Takuma Tsuchida, Takahiro Oguma, Anna Marley, Charlotte Wennberg-Huldt, Daniel Hovdal, Hajime Fukuda, Yukimi Yoneyama, Kazuyo Sasaki, Anders Johansson, Sara Lundqvist, Johan Brengdahl, Richard J Isaacs, Daniel Brown, Stefan Geschwindner, Lambertus Benthem, Claire Priest, Andrew Turnbull
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145849 (2015)
Type 2 diabetes (T2D) occurs when there is insufficient insulin release to control blood glucose, due to insulin resistance and impaired β-cell function. The GPR39 receptor is expressed in metabolic tissues including pancreatic β-cells and has been
Externí odkaz:
https://doaj.org/article/64efe16b0e9f431eb9ae335a14c2bfc8
Autor:
ANNA MARLEY
Publikováno v:
The Unforgettables ISBN: 9780520385573
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77f30a11fcafad781d19d9e503eea217
https://doi.org/10.2307/j.ctv32fs57r.14
https://doi.org/10.2307/j.ctv32fs57r.14
Autor:
Vijay Gottipati, Anna Marley, William L. McPheat, Bronson A. Haynes, Lindsey Glenn, Jerry L. Nadler, Göran I. Hansson, Ryan W. Huyck, Anca D. Dobrian
Publikováno v:
Prostaglandins & Other Lipid Mediators. 136:23-32
The 12-lipoxygenase (12LO) pathway is a promising target to reduce islet dysfunction, adipose tissue (AT) inflammation and insulin resistance. Optimal pre-clinical models for the investigation of selective12LO inhibitors in this context have not yet
Autor:
Frank Reimann, David J. Hodson, Antonia Solomou, Guy A. Rutter, Gabriela da Silva Xavier, Helen E. Parker, Claire Priest, Gao Sun, Stéphanie Migrenne, Anna Marley, Tracy Gorman, Benoit Viollet, Pedro Luis Herrera, Christophe Magnan, Fiona M. Gribble, Marc Foretz
Publikováno v:
Molecular metabolism
Molecular metabolism, Elsevier, 2015, 4 (4), pp.277-86. ⟨10.1016/j.molmet.2015.01.006⟩
Molecular Metabolism, Vol 4, Iss 4, Pp 277-286 (2015)
Molecular metabolism, Elsevier, 2015, 4 (4), pp.277-86. 〈10.1016/j.molmet.2015.01.006〉
Molecular Metabolism, Vol. 4, No 4 (2015) pp. 277-286
Molecular metabolism, 2015, 4 (4), pp.277-86. ⟨10.1016/j.molmet.2015.01.006⟩
Molecular metabolism, Elsevier, 2015, 4 (4), pp.277-86. ⟨10.1016/j.molmet.2015.01.006⟩
Molecular Metabolism, Vol 4, Iss 4, Pp 277-286 (2015)
Molecular metabolism, Elsevier, 2015, 4 (4), pp.277-86. 〈10.1016/j.molmet.2015.01.006〉
Molecular Metabolism, Vol. 4, No 4 (2015) pp. 277-286
Molecular metabolism, 2015, 4 (4), pp.277-86. ⟨10.1016/j.molmet.2015.01.006⟩
Aims/Hypothesis: Glucagon release from pancreatic alpha cells is required for normal glucose homoeostasis and is dysregulated in both Type 1 and Type 2 diabetes. The tumour suppressor LKB1 (STK11) and the downstream kinase AMP-activated protein kinas
Autor:
Anna Marley, Melker Göransson, Therese Admyre, Jan Oscarsson, David M. Smith, Mikael Bjursell, Mohammad Bohlooly-Y
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 300:E211-E220
Free fatty acid receptor 2 (Ffar2), also known as GPR43, is activated by short-chain fatty acids (SCFA) and expressed in intestine, adipocytes, and immune cells, suggesting involvement in lipid and immune regulation. In the present study, Ffar2-defic
Autor:
Guy A. Rutter, Paul M. W. French, Anna Marley, Isabelle Leclerc, Fiona M. Gribble, Andrei I. Tarasov, James McGinty, G. da Silva Xavier, Helen E. Parker, Angela McDonald, Frank Reimann, Tracy Gorman, Gao Sun, Benoit Viollet, O. Prendiville, Raffaella Carzaniga
Publikováno v:
Diabetologia. 53:924-936
AMP-activated protein kinase (AMPK) is an evolutionarily conserved enzyme and a target of glucose-lowering agents, including metformin. However, the precise role or roles of the enzyme in controlling insulin secretion remain uncertain.The catalytic a
Autor:
Geoffrey D. Holman, David E. James, Anna Marley, Daniel J. Fazakerley, Jacqueline Stöckli, Adelle C.F. Coster
Publikováno v:
The Journal of Biological Chemistry
In L6 myotubes, redistribution of a hemagglutinin (HA) epitope-tagged GLUT4 (HA-GLUT4) to the cell surface occurs rapidly in response to insulin stimulation and AMP-activated protein kinase (AMPK) activation. We have examined whether these separate s