Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Anna Marie Beckmann"'
Autor:
Zachary K. Sagawa, Cristina Goman, Aude Frevol, Azra Blazevic, Janice Tennant, Bridget Fisher, Tracey Day, Stephen Jackson, Franck Lemiale, Leon Toussaint, Irene Kalisz, Joe Jiang, Lisa Ondrejcek, Raodoh Mohamath, Julie Vergara, Alan Lew, Anna Marie Beckmann, Corey Casper, Daniel F. Hoft, Christopher B. Fox
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Here the authors present results from a randomized, double-blinded Phase 1 clinical trial, testing a thermostable presentation of a clinical-stage adjuvanted subunit tuberculosis vaccine candidate. The vaccine candidate is safe and well tolerated, an
Externí odkaz:
https://doaj.org/article/0416e608bded4e49acce0289f6385372
Autor:
Tazio Vanni, Beatriz C. Thomé, Erin Sparrow, Martin Friede, Christopher B. Fox, Anna Marie Beckmann, Chuong Huynh, Gabriella Mondini, Daniela H. Silveira, Juliana Y. K. Viscondi, Patrícia Emilia Braga, Anderson da Silva, Maria da Graça Salomão, Roberta O. Piorelli, Joane P. Santos, Vera Lúcia Gattás, Maria Beatriz B. Lucchesi, Mayra M. M. de Oliveira, Marcelo E. Koike, Esper G. Kallas, Lucia M. A. Campos, Eduardo B. Coelho, Marilda A. M. Siqueira, Cristiana C. Garcia, Milene Dias Miranda, Terezinha M. Paiva, Maria do Carmo S. T. Timenetsky, Eduardo A. Adami, Milena A. Akamatsu, Paulo Lee Ho, Alexander R. Precioso
Publikováno v:
PLoS ONE, Vol 17, Iss 10 (2022)
The emergence of potentially pandemic viruses has resulted in preparedness efforts to develop candidate vaccines and adjuvant formulations. We evaluated the dose-sparing effect and safety of two distinct squalene-based oil-in-water adjuvant emulsion
Externí odkaz:
https://doaj.org/article/5ee6497bf41b443da8fab583e15ed70d
Autor:
Timothy S. Dutill, Michelle C. Archer, Joseph McCollum, Chris Press, Lisa McNeill, Linda Hawkins, Tony Phan, Erik D. Laursen, Richard Cabullos, Lisa Bouchard, Regie J. Castro, Mong-Wu Lin, Jeralyn Roco, Cecile Blois, Babatunde A. Adeagbo, Jeffrey A. Guderian, Alana Gerhardt, Anna Marie Beckmann, Edward H. Trappler, Ryan M. Kramer, Christopher B. Fox
Publikováno v:
Frontiers in Drug Delivery. 2
Promising clinical efficacy results have generated considerable enthusiasm for the potential impact of adjuvant-containing subunit tuberculosis vaccines. The development of a thermostable tuberculosis vaccine formulation could have significant benefi
Autor:
Rhea N. Coler, Tracey A. Day, Ruth Ellis, Franco M. Piazza, Anna Marie Beckmann, Julie Vergara, Tom Rolf, Lenette Lu, Galit Alter, David Hokey, Lakshmi Jayashankar, Robert Walker, Margaret Ann Snowden, Tom Evans, Ann Ginsberg, Steven G. Reed, The TBVPX-113 Study Team
Publikováno v:
npj Vaccines, Vol 3, Iss 1, Pp 1-9 (2018)
NPJ Vaccines
NPJ Vaccines
Tuberculosis (TB) is the leading cause of infectious death worldwide. Development of improved TB vaccines that boost or replace BCG is a major global health goal. ID93 + GLA-SE is a fusion protein TB vaccine candidate combined with the Toll-like Rece
Autor:
Julia Amsterdam, Alessandro Companie, Fajwa Opperman, Justin Shenje, Steven G. Reed, Elma Van Rooyen, Sandra Goliath, Julia Noble, Tom Rolf, Friedrich Thienemann, Ann Swarts, Rhea N. Coler, Amaryl Van Schalkwyk, Linda-Gail Bekker, Sarah Albertson, Alessandro Sette, Erica Smit, Angelique Mouton, Michele Tameris, Zachary K. Sagawa, Lebohang Makhethe, Yolandi Herselman, Aude Frevol, Yolundi Cloete, Simbarashe Mabwe, Nicole Bilek, Angelique Kany Kany Luabeya, Alana Keyser, Cecilia S. Lindestam Arlehamn, Andrew Fiore-Gartland, Tracey A. Day, Asma Toefy, Carolyn Jones, Thomas J. Scriba, Linda van der Merwe, Constance Schreuder, Natasja Botes, Susan Rossouw, Andreas H. Diacon, Humphrey Mulenga, Adam Penn-Nicholson, Devona Hofmeester, Sandra Kruger, Nelita du Plessis, Fan-Chi Hsu, Jill A. Ashman, Julie Vergara, Anna Marie Beckmann, Eunice Sinandile, Andre G. Loxton, Elisabeth Filander, Ashley Veldsman, Andrea Gutschmidt, Marwou de Kock, Leya Hassanally, Hadn Africa, Stuart Kahn, Yiwen Lu, Marcia Steyn, Timothy D. Reid, Gerhard Walzl, Gail Jacobs, Elize van der Riet, Mark Hatherill, Cynthia Ontong, Nambitha Quaqua, H. Geldenhuys
Publikováno v:
The Lancet. Respiratory medicine. 9(4)
Summary Background A therapeutic vaccine that prevents recurrent tuberculosis would be a major advance in the development of shorter treatment regimens. We aimed to assess the safety and immunogenicity of the ID93 + GLA-SE vaccine at various doses an
Autor:
Efrat Kochba, Nathalie Landry, Steven G. Reed, Khin Nu, Darrick Carter, Anna Marie Beckmann, Susan L. Baldwin, Al Magill, Zachary K. Sagawa, Neal Van Hoeven, Nathalie Charland, Jill A. Ashman, Yotam Levin, Aude Frevol
Publikováno v:
Science Advances
We present an adjuvant for intradermal use that works in humans, enabling self-administration in case of a flu pandemic.
Adjuvants are key to shaping the immune response to vaccination, but to date, no adjuvant suitable for human use has been de
Adjuvants are key to shaping the immune response to vaccination, but to date, no adjuvant suitable for human use has been de
Toll-like receptor (TLR) 4 ligands represent a unique class of adjuvant molecules. Among the few types of adjuvants employed in products approved for human use, only appropriately formulated TLR4 ligands have been shown to activate a specific pattern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2abd9657b87625c2c2eee66413f30695
https://doi.org/10.1016/b978-0-12-804019-5.00006-2
https://doi.org/10.1016/b978-0-12-804019-5.00006-2
Autor:
Upasna Gaur Dixit, Rhea N. Coler, Anna Marie Beckmann, Patricia L. Winokur, Allison F. Christiaansen, Steven M. Varga, Mary E. Wilson, M. Bridget Zimmerman, Steven G. Reed
Publikováno v:
Vaccine
Background Determining the efficacy of human vaccines that induce antigen-specific protective CD4 T cell responses against pathogens can be particularly challenging to evaluate. Surface expression of CD11a and CD49d has been shown to identify antigen
Autor:
Sonali Trivedi, Vijay K. Rai, Steven G. Reed, Subodh Kumar, Anna Marie Beckmann, Stuart J. Kahn, Karen D. Cowgill, Shyam Sundar, Jaya Chakravarty, Franco M. Piazza, Elsa M. Laughlin, Anup Singh, Rhea N. Coler, Jill A. Ashman
Publikováno v:
Vaccine. 29:3531-3537
Healthy Indian adult volunteers, with or without a history of leishmaniasis, were evaluated for evidence of previous infection with Leishmania donovani based on the direct agglutination test (DAT). Three cohorts of 6 DAT-negative and 6 DAT-positive s
Autor:
Steven G. Reed, Stuart J. Kahn, Karen D. Cowgill, Anna Marie Beckmann, Wessmark Calderon, Elsa M. Laughlin, Lisa Y. Bogatzki, Maria Cruz, Fabiana P. Alves, Rhea N. Coler, Sylvie Bertholet, Jill A. Ashman, Franco M. Piazza, Alejandro Llanos-Cuentas
Publikováno v:
Vaccine. 28:7427-7435
Adult patients with mucosal leishmaniasis (ML) were enrolled in a randomized, double-blind, placebo-controlled, dose-escalating clinical trial and were randomly assigned to receive three injections of either the LEISH-F1+MPL-SE vaccine (consisting of