Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Anna Maria Marini"'
Autor:
Elisabetta Barresi, Rahul Ravichandran, Lorenzo Germelli, Andrea Angeli, Emma Baglini, Silvia Salerno, Anna Maria Marini, Barbara Costa, Eleonora Da Pozzo, Claudia Martini, Federico Da Settimo, Claudiu Supuran, Sandro Cosconati, Sabrina Taliani
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1783-1797 (2021)
Carbonic Anhydrase Activators (CAAs) could represent a novel approach for the treatment of Alzheimer’s disease, ageing, and other conditions that require remedial achievement of spatial learning and memory therapy. Within a research project aimed a
Externí odkaz:
https://doaj.org/article/61803acb569c43b59486f5dce895777a
Autor:
Emma Baglini, Rahul Ravichandran, Emanuela Berrino, Silvia Salerno, Elisabetta Barresi, Anna Maria Marini, Monica Viviano, Sabrina Castellano, Federico Da Settimo, Claudiu T. Supuran, Sandro Cosconati, Sabrina Taliani
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1874-1883 (2021)
A library of variously decorated N-phenyl secondary sulphonamides featuring the bicyclic tetrahydroquinazole scaffold was synthesised and biologically evaluated for their inhibitory activity against human carbonic anhydrase (hCA) I, II, IV, and IX. O
Externí odkaz:
https://doaj.org/article/88031813ab9443118c310ad8a0e3ccdb
Autor:
Gordon Williamson, Ana Sofia Brito, Adriana Bizior, Giulia Tamburrino, Gaëtan Dias Mirandela, Thomas Harris, Paul A. Hoskisson, Ulrich Zachariae, Anna Maria Marini, Mélanie Boeckstaens, Arnaud Javelle
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Ammonium translocation through biological membranes, by the ubiquitous Amt-Mep-Rh family of transporters, plays a key role in all domains of life. Two highly conserved histidine residues protrude into the lumen of the pore of these transport
Externí odkaz:
https://doaj.org/article/cc220a8cb6be485b8d249deacb618d7c
Autor:
Ana Sofia Brito, Silvia Soto Diaz, Pascale Van Vooren, Patrice Godard, Anna Maria Marini, Mélanie Boeckstaens
Publikováno v:
iScience, Vol 20, Iss , Pp 415-433 (2019)
Summary: To adjust cell growth and metabolism according to environmental conditions, the conserved TORC1 signaling network controls autophagy, protein synthesis, and turnover. Here, we dissected the signals controlling phosphorylation and activity of
Externí odkaz:
https://doaj.org/article/86916cfaa7fe4f7d832e58e9a7d2eff7
Autor:
Gordon Williamson, Giulia Tamburrino, Adriana Bizior, Mélanie Boeckstaens, Gaëtan Dias Mirandela, Marcus G Bage, Andrei Pisliakov, Callum M Ives, Eilidh Terras, Paul A Hoskisson, Anna Maria Marini, Ulrich Zachariae, Arnaud Javelle
Publikováno v:
eLife, Vol 9 (2020)
The transport of charged molecules across biological membranes faces the dual problem of accommodating charges in a highly hydrophobic environment while maintaining selective substrate translocation. This has been the subject of a particular controve
Externí odkaz:
https://doaj.org/article/46bab61e73654c119810b3aa4dcdde01
Publikováno v:
PLoS Genetics, Vol 16, Iss 2, p e1008634 (2020)
The dimorphic transition from the yeast to the filamentous form of growth allows cells to explore their environment for more suitable niches and is often crucial for the virulence of pathogenic fungi. In contrast to their Mep1/3 paralogues, fungal Me
Externí odkaz:
https://doaj.org/article/88b46f6946984b7bbe2d14b3b34be9a3
Autor:
Mélanie Boeckstaens, Ahmad Merhi, Elisa Llinares, Pascale Van Vooren, Jean-Yves Springael, René Wintjens, Anna Maria Marini
Publikováno v:
PLoS Genetics, Vol 11, Iss 7, p e1005382 (2015)
Fine-tuning the plasma-membrane permeability to essential nutrients is fundamental to cell growth optimization. Nutritional signals including nitrogen availability are integrated by the TORC1 complex which notably regulates arrestin-mediated endocyto
Externí odkaz:
https://doaj.org/article/36fb95f525b043fd9981b8741dd1e578
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128683 (2015)
Ammonium is a metabolic waste product mainly detoxified by the liver. Hepatic dysfunction can lead to cytotoxic accumulation of circulating ammonium and to subsequent encephalopathy. Transmembrane ammonium transport is a widely spread process ensured
Externí odkaz:
https://doaj.org/article/4bb5a1f80c2d42139fcf41d487e88ee8
Autor:
Andreas Pfannmüller, Dominik Wagner, Christian Sieber, Birgit Schönig, Mélanie Boeckstaens, Anna Maria Marini, Bettina Tudzynski
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0125487 (2015)
The rice pathogenic fungus Fusarium fujikuroi is well known for the production of a broad spectrum of secondary metabolites (SMs) such as gibberellic acids (GAs), mycotoxins and pigments. The biosynthesis of most of these SMs strictly depends on nitr
Externí odkaz:
https://doaj.org/article/3651ff39a0fa47378e4393a0c43d4492
Autor:
Aude Deschuyteneer, Mélanie Boeckstaens, Christelle De Mees, Pascale Van Vooren, René Wintjens, Anna Maria Marini
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71092 (2013)
Proteins of the conserved Mep-Amt-Rh family, including mammalian Rhesus factors, mediate transmembrane ammonium transport. Ammonium is an important nitrogen source for the biosynthesis of amino acids but is also a metabolic waste product. Its disposa
Externí odkaz:
https://doaj.org/article/159e8141b1444204b6c65186496796da