Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Anna Maria Giuliani"'
Autor:
Elisamaria Tasca, Mauro Giustini, Alessandra Del Giudice, Sergio Moya, Luciano Galantini, Maria de los Angeles Ramirez, Karin Schillén, Patrizia Andreozzi, Anna Maria Giuliani
Hypothesis Doxorubicin hydrochloride (DX) is widely used as a chemotherapeutic agent, though its severe side-effects limit its clinical use. A way to overcome these limitations is to increase DX latency through encapsulation in suitable carriers. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e1919c800fa9638a613d38a0ce8c92f
https://zenodo.org/record/3994207
https://zenodo.org/record/3994207
Autor:
Nicolae Viorel Pavel, Marco D'Abramo, Luciano Galantini, Anna Maria Giuliani, Mauro Giustini, Gerardo Palazzo, Elisamaria Tasca
Publikováno v:
Chemistry - A European Journal. 24:8195-8204
Anthracyclines self-assemble in water into dimers. In the presence of sufficiently high salt (NaCl) concentrations, solutions of the antibiotic doxorubicin, but not those of the closely related molecules daunomycin and epirubicin, turn into gels bare
Autor:
Andrea Amadei, Anna Maria Giuliani, Elisamaria Tasca, Josephine Alba, Luciano Galantini, Mauro Giustini, Gerardo Palazzo, Marco D'Abramo
The self-association equilibria of doxorubicin hydrochloride (DX), at high drug and NaCl concentrations, are studied by temperature scan fluorescence spectroscopy, with the support of molecular dynamics (MD) calculations. Even though all anthracyclin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b431cae0efd95fedafc1040fdcc76617
http://hdl.handle.net/11573/1277998
http://hdl.handle.net/11573/1277998
Autor:
Mauro Giustini, Anna Maria Giuliani, Karin Schillén, Alessandra Del Giudice, Luciano Galantini, Elisamaria Tasca
Hypothesis Doxorubicin hydrochloride (DX) is one of the most powerful anticancer agents though its clinical use is impaired by severe undesired side effects. DX encapsulation in nanocarrier systems has been introduced as a mean to reduce its toxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d30992441839d7d8dd0f0e12dfb8d89
http://hdl.handle.net/11573/1216535
http://hdl.handle.net/11573/1216535
Publikováno v:
Biochemistry. 53:2197-2207
The interaction of doxorubicin (DX) with model polynucleotides poly(dG-dC)·poly(dG-dC) (polyGC), poly(dA-dT)·poly(dA-dT) (polyAT), and calf thymus DNA has been studied by several spectroscopic techniques in phosphate buffer aqueous solutions. UV-vi
Two metal complexes of 2,2′:6′,2′′-terpyridine (terpy), i.e. Cd(terpy)Cl2 and Ni(terpy)Cl2·3H2O, have been prepared and extensively characterized. The interaction of Cd(terpy)Cl2 with synthetic DNA models, poly(dA-dT)·poly(dA-dT) (polyAT) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306a051c32a74dcd5d81db9740a3a5b3
http://hdl.handle.net/10447/225803
http://hdl.handle.net/10447/225803
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 29:585-594
When the model polynucleotide poly(dG-dC)∙poly(dG-dC) [polyGC] is titrated with a strong acid (HCl) in unbuffered aqueous solutions containing the chlorides of the alkali metals in the concentration range 0.010 M-0.600 M, two transitions in the abs
Autor:
C. Andrea Boicelli, Marcello Giomini, Anna Maria Giuliani, Marta Airoldi, Mauro Giustini, Giuseppe Gennaro
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 23:465-477
The model polynucleotide poly(dG-dC).poly(dG-dC) (polyGC) was titrated with a strong acid (HCl) in aqueous unbuffered solutions and in the quaternary w/o microemulsion CTAB/n-pentanol/n-hexane/water. The titrations, performed at several concentration
Autor:
Mauro Giustini, Giuseppe Gennaro, Fabio Cadoni, Marta Airoldi, C. Andrea Boicelli, Marcello Giomini, Anna Maria Giuliani
Publikováno v:
Biopolymers. 75:118-127
CD and uv absorption data showed that high molecular weight poly(dA-dT) . poly(dA-dT), at 298 K, undergoes an acid-induced transition from B-double helix to random coil in NaCl solutions of different concentrations, ranging from 0.005 to 0.600M. Simi
Autor:
Marcello Giomini, Mauro Giustini, Giuseppe Gennaro, Fabio Cadoni, Anna Maria Giuliani, C. Andrea Boicelli, Marta Airoldi
Publikováno v:
Phys. Chem. Chem. Phys.. 6:1453-1457
CD and UV spectroscopies have been used to investigate the effects caused by the addition of either strong acid-or base-containing microemulsions on the behaviour of the synthetic polynucleotide polyAT entrapped in the aqueous core of a cationic quat