The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species.

Autor: Daniela Niemeyer, Kirstin Mösbauer, Eva M Klein, Andrea Sieberg, Robert C Mettelman, Anna M Mielech, Ronald Dijkman, Susan C Baker, Christian Drosten, Marcel A Müller

Publikováno v: PLoS Pathogens, Vol 14, Iss 9, p e1007296 (2018)

SARS-coronavirus (CoV) is a zoonotic agent derived from rhinolophid bats, in which a plethora of SARS-related, conspecific viral lineages exist. Whereas the variability of virulence among reservoir-borne viruses is unknown, it is generally assumed th

Externí odkaz: https://doaj.org/article/e2c3a18d260f4854ab9ea12b5d41be2e

The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species

Autor: Marcel A. Müller, E. Klein, Daniela Niemeyer, Kirstin Mösbauer, Robert C. Mettelman, Christian Drosten, Anna M. Mielech, Ronald Dijkman, Susan C. Baker, Andrea Sieberg

Publikováno v: PLoS Pathogens, Vol 14, Iss 9, p e1007296 (2018)
PLoS Pathogens
Niemeyer, Daniela; Mösbauer, Kirstin; Klein, Eva M; Sieberg, Andrea; Mettelman, Robert C; Mielech, Anna M; Dijkman, Ronald; Baker, Susan C; Drosten, Christian; Müller, Marcel A (2018). The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species. PLoS pathogens, 14(9), e1007296. Public Library of Science 10.1371/journal.ppat.1007296
PLOS Pathogens

SARS-coronavirus (CoV) is a zoonotic agent derived from rhinolophid bats, in which a plethora of SARS-related, conspecific viral lineages exist. Whereas the variability of virulence among reservoir-borne viruses is unknown, it is generally assumed th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27e077008961a8bbf2170807c7ccbd5
https://doaj.org/article/e2c3a18d260f4854ab9ea12b5d41be2e

Murine Coronavirus Ubiquitin-Like Domain Is Important for Papain-Like Protease Stability and Viral Pathogenesis

Autor: Eveline Kindler, Xufang Deng, Volker Thiel, Dorthea L. Wheeler, Stanley Perlman, Anna M. Mielech, Andrew D. Mesecar, Susan C. Baker, Yafang Chen

Publikováno v: Journal of Virology

Ubiquitin-like domains (Ubls) now are recognized as common elements adjacent to viral and cellular proteases; however, their function is unclear. Structural studies of the papain-like protease (PLP) domains of coronaviruses (CoVs) revealed an adjacen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326127eb8bbedbc5629a0d65874da884

Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages

Autor: Robert C. Mettelman, Xufang Deng, Amornrat O'Brien, Susan C. Baker, Anna M. Mielech, C. Cheng Kao, Guanghui Yi, Matthew Hackbart

Publikováno v: Proceedings of the National Academy of Sciences

Coronaviruses are positive-sense RNA viruses that generate double-stranded RNA (dsRNA) intermediates during replication, yet evade detection by host innate immune sensors. Here we report that coronavirus nonstructural protein 15 (nsp15), an endoribon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd13df2f2ae3040de6968986e5267abf
https://doi.org/10.1073/pnas.1618310114

X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases

Autor: Michael P. Agius, Scott D. Larsen, Scott J. Barraza, Nicole M. Davis, Michael W. Wilson, Yahira M. Báez-Santos, Anna M. Mielech, Andrew D. Mesecar, Susan C. Baker

Publikováno v: Journal of Medicinal Chemistry

Structure-guided design was used to generate a series of noncovalent inhibitors with nanomolar potency against the papain-like protease (PLpro) from the SARS coronavirus (CoV). A number of inhibitors exhibit antiviral activity against SARS-CoV infect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c793cf3b7b1caaba5150d98618621b