Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Anna M. Krichevsky"'
Autor:
Lien D. Nguyen, Zhiyun Wei, M. Catarina Silva, Sergio Barberán-Soler, Jiarui Zhang, Rosalia Rabinovsky, Christina R. Muratore, Jonathan M. S. Stricker, Colin Hortman, Tracy L. Young-Pearse, Stephen J. Haggarty, Anna M. Krichevsky
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract MicroRNAs (miRNAs) regulate fundamental biological processes by silencing mRNA targets and are dysregulated in many diseases. Therefore, miRNA replacement or inhibition can be harnessed as potential therapeutics. However, existing strategies
Externí odkaz:
https://doaj.org/article/b8a8e54f65f640bfad7b904c07567fde
Autor:
Yanhong Zhang, Rosalia Rabinovsky, Zhiyun Wei, Rachid El Fatimy, Evgeny Deforzh, Bai Luan, Leonid Peshkin, Erik J. Uhlmann, Anna M. Krichevsky
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 265-275 (2023)
MicroRNA-10b (miR-10b) is an essential glioma driver and one of the top candidates for targeted therapies for glioblastoma and other cancers. This unique miRNA controls glioma cell cycle and viability via an array of established conventional and unco
Externí odkaz:
https://doaj.org/article/10a4b48db9e44e428e91f68ba2b1e1e6
Publikováno v:
Cells, Vol 12, Iss 22, p 2660 (2023)
While it is well known that 98–99% of the human genome does not encode proteins, but are nevertheless transcriptionally active and give rise to a broad spectrum of noncoding RNAs [ncRNAs] with complex regulatory and structural functions, specific f
Externí odkaz:
https://doaj.org/article/ae6768801d8545108bcafe6cbe0c9d95
Autor:
Rachid El Fatimy, Yanhong Zhang, Evgeny Deforzh, Mahalakshmi Ramadas, Harini Saravanan, Zhiyun Wei, Rosalia Rabinovsky, Nadiya M. Teplyuk, Erik J. Uhlmann, Anna M. Krichevsky
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-19 (2022)
Abstract Background miRNAs are regulatory transcripts established as repressors of mRNA stability and translation that have been functionally implicated in carcinogenesis. miR-10b is one of the key onco-miRs associated with multiple forms of cancer.
Externí odkaz:
https://doaj.org/article/f937b4f91e9b476aa787c3a706e91a6a
Autor:
Ailiang Zeng, Zhiyun Wei, Rosalia Rabinovsky, Hyun Jung Jun, Rachid El Fatimy, Evgeny Deforzh, Ramil Arora, Yizheng Yao, Shun Yao, Wei Yan, Erik J. Uhlmann, Alain Charest, Yongping You, Anna M. Krichevsky
Publikováno v:
iScience, Vol 23, Iss 8, Pp 101420- (2020)
Summary: Glioblastoma (GBM) may arise from astrocytes through a multistep process involving a progressive accumulation of mutations. We explored whether GBM-derived extracellular vesicles (EVs) may facilitate neoplastic transformation and malignant g
Externí odkaz:
https://doaj.org/article/affd28779865474595993f92557b0b03
Publikováno v:
Genes, Vol 12, Iss 12, p 2005 (2021)
Despite the enormous burden of Alzheimer’s disease and related dementias (ADRD) on patients, caregivers, and society, only a few treatments with limited efficacy are currently available. While drug development conventionally focuses on disease-asso
Externí odkaz:
https://doaj.org/article/d950e9fdffe64819870447d708e479ea
Autor:
Zhiyun Wei, Xingjun Meng, Rachid El Fatimy, Bowen Sun, Dongmei Mai, Junfang Zhang, Ramil Arora, Ailiang Zeng, Pingyi Xu, Shaogang Qu, Anna M. Krichevsky, Dennis J. Selkoe, Shaomin Li
Publikováno v:
Neurobiology of Disease, Vol 134, Iss , Pp - (2020)
As the most common cause of progressive cognitive decline in humans, Alzheimer's disease (AD) has been intensively studied, but the mechanisms underlying its profound synaptic dysfunction remain unclear. Here we confirm that exposing wild-type mice t
Externí odkaz:
https://doaj.org/article/0555bcd7882b4d0fb94610581f5138af
Autor:
Rocco Lucero, Valentina Zappulli, Alessandro Sammarco, Oscar D. Murillo, Pike See Cheah, Srimeenakshi Srinivasan, Eric Tai, David T. Ting, Zhiyun Wei, Matthew E. Roth, Louise C. Laurent, Anna M. Krichevsky, Xandra O. Breakefield, Aleksandar Milosavljevic
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2065-2074.e4 (2020)
Summary: Glioblastoma (GBM) is characterized by aberrant vascularization and a complex tumor microenvironment. The failure of anti-angiogenic therapies suggests pathways of GBM neovascularization, possibly attributable to glioblastoma stem cells (GSC
Externí odkaz:
https://doaj.org/article/fc3e84da265140dfa24968d38eea26a6
Autor:
Erik R. Abels, Sybren L.N. Maas, Lisa Nieland, Zhiyun Wei, Pike See Cheah, Eric Tai, Christy-Joy Kolsteeg, Sophie A. Dusoswa, David T. Ting, Suzanne Hickman, Joseph El Khoury, Anna M. Krichevsky, Marike L.D. Broekman, Xandra O. Breakefield
Publikováno v:
Cell Reports, Vol 28, Iss 12, Pp 3105-3119.e7 (2019)
Summary: Gliomas are primary, diffusely infiltrating brain tumors. Microglia are innate immune cells in the CNS and make up a substantial portion of the tumor mass. Glioma cells shape their microenvironment, communicating with and reprogramming surro
Externí odkaz:
https://doaj.org/article/77fbde4a03344664a5847ccb72526d8d
Autor:
Zhiyun Wei, Arsen O. Batagov, Sergio Schinelli, Jintu Wang, Yang Wang, Rachid El Fatimy, Rosalia Rabinovsky, Leonora Balaj, Clark C. Chen, Fred Hochberg, Bob Carter, Xandra O. Breakefield, Anna M. Krichevsky
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
While circulating DNA has been extensively explored as a potential cancer biomarker, RNA potential has been overlooked so far. Here the authors present a comprehensive analysis of extracellular RNA secreted by glioblastoma cells that could prove a va
Externí odkaz:
https://doaj.org/article/25f5c51de7fe4c82a5f6c0fe04050e91