Výsledky vyhledávání - "Anna M. Cerny"

Akademický článek

CD200R1 supports HSV-1 viral replication and licenses pro-inflammatory signaling functions of TLR2.

Autor: Roy J Soberman, Christopher R MacKay, Christine A Vaine, Glennice Bowen Ryan, Anna M Cerny, Mikayla R Thompson, Boris Nikolic, Valeria Primo, Peter Christmas, Paul Sheiffele, Lisa Aronov, David M Knipe, Evelyn A Kurt-Jones

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e47740 (2012)

The CD200R1:CD200 axis is traditionally considered to limit tissue inflammation by down-regulating pro-inflammatory signaling in myeloid cells bearing the receptor. We generated CD200R1(-/-) mice and employed them to explore both the role of CD200R1

Externí odkaz: https://doaj.org/article/b89806b6104e487bb5874dc3f2af1e21

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A Fluorescent Reporter Mouse for Inflammasome Assembly Demonstrates an Important Role for Cell-Bound and Free ASC Specks during In Vivo Infection

Autor: Brian G. Monks, Katherine A. Fitzgerald, Te-Chen Tzeng, Anna M. Cerny, Donghai Wang, Stefan A. Schattgen, Eicke Latz, Douglas T. Golenbock

Publikováno v: Cell Reports, Vol 16, Iss 2, Pp 571-582 (2016)

Summary Inflammasome activation is associated with numerous diseases. However, in vivo detection of the activated inflammasome complex has been limited by a dearth of tools. We have developed transgenic mice that ectopically express the fluorescent a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::924c162b3ffd050bbccb6f5606721311

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Induction and Inhibition of Type I Interferon Responses by Distinct Components of Lymphocytic Choriomeningitis Virus

Autor: Shenghua Zhou, An Zacharia, Katherine A. Fitzgerald, Evelyn A. Kurt-Jones, Robert W. Finberg, Anna M. Cerny

Publikováno v: Journal of Virology. 84:9452-9462

Type I interferons (IFNs) play a critical role in the host defense against viruses. Lymphocytic choriomeningitis virus (LCMV) infection induces robust type I IFN production in its natural host, the mouse. However, the mechanisms underlying the induct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55ee090884586ab2888faa5529df92c
https://doi.org/10.1128/jvi.00155-10

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Mutations in Bone Marrow-Derived Stromal Stem Cells Unmask Latent Malignancy

Autor: Christine Hewes, Theofilos Poutahidis, Glennice N. Bowen, Yingwang Liu, Jian Hua Liu, Hanchen Li, Anna M. Cerny, Stephen Lyle, Varada P. Rao, Nathan F. Moore, Xueli Fan, Susan E. Erdman, JeanMarie Houghton, Christine L. Taylor, Jan Cerny, Evelyn A. Kurt-Jones, Erin A. Jackson

Publikováno v: Stem Cells and Development. 19:1153-1166

Neoplastic epithelia may remain dormant and clinically unapparent in human patients for decades. Multiple risk factors including mutations in tumor cells or the stromal cells may affect the switch from dormancy to malignancy. Gene mutations, includin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664978f1fca4d7a944f3bf3ca4e3411d
https://doi.org/10.1089/scd.2009.0439

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Human erythrocytes bind and inactivate type 5 adenovirus by presenting Coxsackie virus-adenovirus receptor and complement receptor 1

Autor: Andreas F.-P. Sonnen, N K Green, Anna M. Cerny, Leonard W. Seymour, Kerry D. Fisher, Robert B. Sim, Vladimir Subr, Robert J.C. Gilbert, Y Di, Robert W. Finberg, Karel Ulbrich, Robert Carlisle

Publikováno v: Blood

Type 5 adenovirus (Ad5) is a human pathogen that has been widely developed for therapeutic uses, with only limited success to date. We report here the novel finding that human erythrocytes present Coxsackie virus-adenovirus receptor (CAR) providing a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aff0399378b98bf1bcbdf5181ac264a9
https://doi.org/10.1182/blood-2008-09-178459

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MyD88 Intrinsically Regulates CD4 T-Cell Responses

Autor: Shenghua Zhou, Melvin Chan, Roderick T. Bronson, Robert W. Finberg, Anna M. Cerny, Evelyn A. Kurt-Jones

Publikováno v: Journal of Virology. 83:1625-1634

Myeloid differentiation factor 88 (MyD88) is an essential adaptor protein in the Toll-like receptor-mediated innate signaling pathway, as well as in interleukin-1 receptor (IL-1R) and IL-18R signaling. The importance of MyD88 in the regulation of inn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2f5343bb101bd77dd0f273b7db23d8c
https://doi.org/10.1128/jvi.01770-08

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Respiratory Syncytial Virus Activates Innate Immunity through Toll-Like Receptor 2

Autor: Evelyn A. Kurt-Jones, Ralph A. Tripp, Robert W. Finberg, Larry J. Anderson, Glennice N. Bowen, Matthew R. Murawski, Lia M. Haynes, Anna M. Cerny

Publikováno v: Journal of Virology. 83:1492-1500

Respiratory syncytial virus (RSV) is a common cause of infection that is associated with a range of respiratory illnesses, from common cold-like symptoms to serious lower respiratory tract illnesses such as pneumonia and bronchiolitis. RSV is the sin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d64405cc4935402b303b44de7b5c0d76
https://doi.org/10.1128/jvi.00671-08

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Toll-like receptor–mediated activation of neutrophils by influenza A virus

Autor: Carolyn Padden, Glennice N. Bowen, Jennifer P. Wang, Robert W. Finberg, Anna M. Cerny, Evelyn A. Kurt-Jones, Peter E. Newburger

Publikováno v: Blood. 112:2028-2034

Influenza virus infection of the respiratory tract is characterized by a neutrophil infiltrate accompanied by inflammatory cytokine and chemokine production. We and others have reported that Toll-like receptor (TLR) proteins are present on human neut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1909cddb127b00bb6c40ce347d452254
https://doi.org/10.1182/blood-2008-01-132860

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Trefoil Family Factor 2 Is Expressed in Murine Gastric and Immune Cells and Controls both Gastrointestinal Inflammation and Systemic Immune Responses

Autor: George W. Reed, James G. Fox, Arlin B. Rogers, Prashant R. Nambiar, Timothy C. Wang, Shigeo Takaishi, Frantisek Sandor, Evelyn A. Kurt-Jones, Glennice N. Bowen, Jing Yan, Alfred L. Chi, JeanMarie Houghton, LuCheng Cao, Mark T. Whary, Anna M. Cerny

Publikováno v: Infection and Immunity. 75:471-480

Trefoil family factor 2 (TFF2), also known as spasmolytic peptide, is a low-molecular-weight protein that is upregulated in gastric tissues infected with Helicobacter or having other inflammatory conditions, but a precise function is yet to be elucid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae6410f0a423fffefb5d569c176ba73
https://doi.org/10.1128/iai.02039-05

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MyD88 is critical for the development of innate and adaptive immunity during acute lymphocytic choriomeningitis virus infection

Autor: Douglas T. Golenbock, Robert W. Finberg, Leisa Mandell, Anna M. Cerny, Melvin Chan, Evelyn A. Kurt-Jones, Shenghua Zhou

Publikováno v: European Journal of Immunology. 35:822-830

We investigated the roles of Toll-like receptor 2 (TLR2) and myeloid differentiation factor 88 (MyD88) in the course of a lymphocytic choriomeningitis virus (LCMV) infection and revealed the following: (i) studies of transfected cells and murine peri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d35a0b363dcc67fef343952aed6284
https://doi.org/10.1002/eji.200425730

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