Gαq activation modulates autophagy by promoting mTORC1 signaling

Autor: Sofía Cabezudo, Maria Sanz-Flores, Alvaro Caballero, Inmaculada Tasset, Elena Rebollo, Antonio Diaz, Anna M. Aragay, Ana María Cuervo, Federico Mayor, Catalina Ribas

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

Nutrient status in the cell regulates autophagy via mTORC1 activity. Here, the authors show that the ubiquitous G protein subunit Gαq contributes to nutrient sensing by promoting formation of an mTOR-p62-Raptor complex in replete conditions, modulat

Externí odkaz: https://doaj.org/article/b633204dd82c4a36a9216ada8eca36a2

Kazrin promotes dynein/dynactin-dependent traffic from early to recycling endosomes

Autor: Ines Hernandez-Perez, Javier Rubio, Adrian Baumann, Henrique Girao, Miriam Ferrando, Elena Rebollo, Anna M Aragay, María Isabel Geli

Publikováno v: eLife, Vol 12 (2023)

Kazrin is a protein widely expressed in vertebrates whose depletion causes a myriad of developmental defects, in part derived from altered cell adhesion and migration, as well as failure to undergo epidermal to mesenchymal transition. However, the pr

Externí odkaz: https://doaj.org/article/05d57bd983924f86a902c5aeee0d26d2

A novel Alex3/Gαq protein complex regulating mitochondrial dynamics, dendritic complexity, and neuronal survival

Autor: Ismael Izquierdo-Villalba, Serena Mirra, Yasmina Manso, Antoni Parcerisas, Javier Rubio, Jaume Del Valle, Francisco J. Gil-Bea, Fausto Ulloa, Marina Herrero-Lorenzo, Ester Verdaguer, Cristiane Benincá, Rubén D. Castro-Torres, Elena Rebollo, Gemma Marfany, Carme Auladell, Xavier Navarro, José A. Enríquez, Adolfo López de Munain, Anna M. Aragay, Eduardo Soriano

In neurons, mitochondrial dynamics and trafficking are essential to provide the energy required for neurotransmission and neuronal activity. Recent studies point to GPCR and G proteins as important regulators of mitochondrial dynamics and energy meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::625cdf89e575a19f4b2cdff578f81e07
https://doi.org/10.1101/2021.12.09.471902

Gαq activation modulates autophagy by promoting mTORC1 signaling

Autor: Anna M. Aragay, Elena Rebollo, Antonio Diaz, Inmaculada Tasset, Alvaro Caballero, Federico Mayor, Maria Sanz-Flores, Ana Maria Cuervo, Sofía Cabezudo, Catalina Ribas

Publikováno v: Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Digital.CSIC. Repositorio Institucional del CSIC

The mTORC1 node plays a major role in autophagy modulation. We report a role of the ubiquitous Gαq subunit, a known transducer of plasma membrane G protein-coupled receptors signaling, as a core modulator of mTORC1 and autophagy. Cells lacking Gαq/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d50a57cfc4efa04aa0b16c49adcdbac
http://hdl.handle.net/10486/702267

Filamin a binds to CCR2B and regulates its internalization.

Autor: Laura Minsaas, Jesús Planagumà, Michael Madziva, Beate F Krakstad, Míriam Masià-Balagué, Arieh A Katz, Anna M Aragay

Publikováno v: PLoS ONE, Vol 5, Iss 8, p e12212 (2010)

The chemokine (C-C motif) receptor 2B (CCR2B) is one of the two isoforms of the receptor for monocyte chemoattractant protein-1 (CCL2), the major chemoattractant for monocytes, involved in an array of chronic inflammatory diseases. Employing the yeas

Externí odkaz: https://doaj.org/article/51341e740e8148a48985d0a652b804d8