Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Anna M Rydzik"'
Autor:
Mun Chiang Chan, Onur Atasoylu, Emma Hodson, Anthony Tumber, Ivanhoe K H Leung, Rasheduzzaman Chowdhury, Verónica Gómez-Pérez, Marina Demetriades, Anna M Rydzik, James Holt-Martyn, Ya-Min Tian, Tammie Bishop, Timothy D W Claridge, Akane Kawamura, Christopher W Pugh, Peter J Ratcliffe, Christopher J Schofield
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132004 (2015)
As part of the cellular adaptation to limiting oxygen availability in animals, the expression of a large set of genes is activated by the upregulation of the hypoxia-inducible transcription factors (HIFs). Therapeutic activation of the natural human
Externí odkaz:
https://doaj.org/article/270e114bd2074970b400b2da1562426e
Autor:
Julie Weidner, Ewa Kolosionek, Reetta Holmila, Elisabeth Ax, Marion Garreau, Felix Gnerlich, Henric Olsson, Werngard Czechtizky, Stefan Vollmer, Anna M. Rydzik
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 898-907 (2023)
MicroRNAs are attractive therapeutic targets in many diseases, including chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. Among microRNA inhibitors antimiRs have been proven successful in lowering aberrant microRNA levels in t
Externí odkaz:
https://doaj.org/article/140a9ff8032c47bc9b3b36ead9a64253
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 81:129126
Autor:
Jürgen Brem, Tharindi Panduwawala, Jon Ulf Hansen, Joanne Hewitt, Edgars Liepins, Pawel Donets, Laura Espina, Alistair J. M. Farley, Kirill Shubin, Gonzalo Gomez Campillos, Paula Kiuru, Shifali Shishodia, Daniel Krahn, Robert K. Leśniak, Juliane Schmidt, Karina Calvopiña, María-Carmen Turrientes, Madeline E. Kavanagh, Dmitrijs Lubriks, Philip Hinchliffe, Gareth W. Langley, Ali F. Aboklaish, Anders Eneroth, Maria Backlund, Andrei G. Baran, Elisabet I. Nielsen, Michael Speake, Janis Kuka, John Robinson, Solveiga Grinberga, Lindsay Robinson, Michael A. McDonough, Anna M. Rydzik, Thomas M. Leissing, Juan Carlos Jimenez-Castellanos, Matthew B. Avison, Solange Da Silva Pinto, Andrew D. Pannifer, Marina Martjuga, Emma Widlake, Martins Priede, Iva Hopkins Navratilova, Marek Gniadkowski, Anna Karin Belfrage, Peter Brandt, Jari Yli-Kauhaluoma, Eric Bacque, Malcolm G. P. Page, Fredrik Björkling, Jonathan M. Tyrrell, James Spencer, Pauline A. Lang, Pawel Baranczewski, Rafael Cantón, Stuart P. McElroy, Philip S. Jones, Fernando Baquero, Edgars Suna, Angus Morrison, Timothy R. Walsh, Christopher J. Schofield
Publikováno v:
Brem, J, Panduwawala, T, Hansen, J U, Hewitt, J, Liepins, E, Donets, P, Espina, L, Farley, A J M, Shubin, K, Campillos, G G, Kiuru, P, Shishodia, S, Krahn, D, Leśniak, R K, Schmidt Adrian, J, Calvopiña, K, Turrientes, M-C, Kavanagh, M E, Lubriks, D, Hinchliffe, P, Langley, G W, Aboklaish, A F, Eneroth, A, Backlund, M, Baran, A G, Nielsen, E I, Speake, M, Kuka, J, Robinson, J, Grinberga, S, Robinson, L, McDonough, M A, Rydzik, A M, Leissing, T M, Jimenez-Castellanos, J C, Avison, M B, Da Silva Pinto, S, Pannifer, A D, Martjuga, M, Widlake, E, Priede, M, Hopkins Navratilova, I, Gniadkowski, M, Belfrage, A K, Brandt, P, Yli-Kauhaluoma, J, Bacque, E, Page, M G P, Björkling, F, Tyrrell, J M, Spencer, J, Lang, P A, Baranczewski, P, Cantón, R, McElroy, S P, Jones, P S, Baquero, F, Suna, E, Morrison, A, Walsh, T R & Schofield, C J 2022, ' Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors ', Nature Chemistry, vol. 14, pp. 15-24 . https://doi.org/10.1038/s41557-021-00831-x
Carbapenems are vital antibiotics, but their efficacy is increasingly compromised by metallo-beta-lactamases (MBLs). Here we report the discovery and optimization of potent broad-spectrum MBL inhibitors. A high-throughput screen for NDM-1 inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4fafe7a19ff7ed314c37086b73a558
https://research-information.bris.ac.uk/ws/files/323318874/IC_MBLinh_NatChem_accepted.pdf
https://research-information.bris.ac.uk/ws/files/323318874/IC_MBLinh_NatChem_accepted.pdf
Publikováno v:
Organic letters. 23(17)
We report a synthesis of a carbocyclic, abasic RNA phosphoramidite decorated with an amino functionality. The building block was efficiently incorporated into an RNA oligonucleotide in a site-specific manner, followed by deprotection to a free amino
Autor:
Robert K. Leśniak, Anna M. Rydzik, Timothy D. W. Claridge, Amjad Kahn, Christopher J. Schofield, Jos J. A. G. Kamps
Publikováno v:
Chemical Communications. 55:14717-14720
The final step in the biosynthesis of l-carnitine in humans is catalysed by the 2-oxoglutarate and ferrous iron dependent oxygenase, γ-butyrobetaine hydroxylase (BBOX). 1H and 19F NMR studies inform on the BBOX mechanism including by providing evide
Autor:
Eric Simon, Jörg F. Rippmann, Doris Riether, Anna M Rydzik, Wioletta Skronska-Wasek, Dirk Gottschling
Publikováno v:
Chembiochem : a European journal of chemical biology. 22(3)
The introduction of N6-methyladenosine (m6 A) into siRNA targeting Factor VII impacts its potency in cells and has a significant influence on the selectivity of siRNA, including reduced off-targeting. These effects are dependent on the position of m6
Autor:
Anna M, Rydzik, Jürgen, Brem, Shane A, Chandler, Justin L P, Benesch, Timothy D W, Claridge, Christopher J, Schofield
Publikováno v:
RSC medicinal chemistry. 11(3)
Autor:
Robert K. Leśniak, Christopher J. Schofield, Anna M. Rydzik, Jürgen Brem, Ivanhoe K. H. Leung, Hwanho Choi, Michael A. McDonough, Timothy D. W. Claridge, Amjad Khan
Publikováno v:
MedChemComm. 7:873-880
γ-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate (2OG) dependent oxygenase that catalyses the stereoselective C-3 hydroxylation of γ-butyrobetaine (GBB) to give L-carnitine. L-carnitine is involved in fatty acid metabolism in all animals and
Autor:
Anna M. Rydzik, Blazej A. Wojtczak, Renata Kasprzyk, Joanna Kowalska, Timothy D. W. Claridge, Anna Nowicka, Jacek Wójcik, Marcin Warminski, Jacek Jemielity, Marek R. Baranowski
Publikováno v:
The Journal of Organic Chemistry. 80:3982-3997
To broaden the scope of existing methods based on (19)F nucleotide labeling, we developed a new method for the synthesis of fluorophosphate (oligo)nucleotide analogues containing an O to F substitution at the terminal position of the (oligo)phosphate