Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Anna M Piskorz"'
Autor:
Maria Vias, Lena Morrill Gavarró, Carolin M Sauer, Deborah A Sanders, Anna M Piskorz, Dominique-Laurent Couturier, Stéphane Ballereau, Bárbara Hernando, Michael P Schneider, James Hall, Filipe Correia-Martins, Florian Markowetz, Geoff Macintyre, James D Brenton
Publikováno v:
eLife, Vol 12 (2023)
High-grade serous ovarian carcinoma (HGSOC) is the most genomically complex cancer, characterized by ubiquitous TP53 mutation, profound chromosomal instability, and heterogeneity. The mutational processes driving chromosomal instability in HGSOC can
Externí odkaz:
https://doaj.org/article/850eb78c25664e2982c8900a7a2a9606
Autor:
Lorenza Mittempergher, Anna M Piskorz, Astrid J Bosma, Magali Michaut, G Bea A Wisman, Roelof J C Kluin, Marja Nieuwland, Wim Brugman, Kevin J W van der Ven, Francesco Marass, James Morris, Nitzan Rosenfeld, Mercedes Jimenez-Linan, Steven de Jong, Ate G J van der Zee, James D Brenton, René Bernards
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0235766 (2020)
High-grade serous ovarian carcinoma (HGSOC) remains the deadliest form of epithelial ovarian cancer and despite major efforts little improvement in overall survival has been achieved. Identification of recurring "driver" genetic lesions has the poten
Externí odkaz:
https://doaj.org/article/7f3ef9cdd1cd4ff0870e2b1e963d3724
Autor:
Christine A Parkinson, Davina Gale, Anna M Piskorz, Heather Biggs, Charlotte Hodgkin, Helen Addley, Sue Freeman, Penelope Moyle, Evis Sala, Karen Sayal, Karen Hosking, Ioannis Gounaris, Mercedes Jimenez-Linan, Helena M Earl, Wendi Qian, Nitzan Rosenfeld, James D Brenton
Publikováno v:
PLoS Medicine, Vol 13, Iss 12, p e1002198 (2016)
BackgroundCirculating tumour DNA (ctDNA) carrying tumour-specific sequence alterations may provide a minimally invasive means to dynamically assess tumour burden and response to treatment in cancer patients. Somatic TP53 mutations are a defining feat
Externí odkaz:
https://doaj.org/article/a390f131ca6d41f198c5c746342604e0
Autor:
Michael P. Schneider, Amy E. Cullen, Justina Pangonyte, Jason Skelton, Harvey Major, Elke Van Oudenhove, Maria J. Garcia, Blas Chaves Urbano, Anna M. Piskorz, James D. Brenton, Geoff Macintyre, Florian Markowetz
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-27 (2024)
Abstract Cancer cells often exhibit DNA copy number aberrations and can vary widely in their ploidy. Correct estimation of the ploidy of single-cell genomes is paramount for downstream analysis. Based only on single-cell DNA sequencing information, s
Externí odkaz:
https://doaj.org/article/9e368e2318e242c8953f09f4b2805e9d
Autor:
Roland F Schwarz, Charlotte K Y Ng, Susanna L Cooke, Scott Newman, Jillian Temple, Anna M Piskorz, Davina Gale, Karen Sayal, Muhammed Murtaza, Peter J Baldwin, Nitzan Rosenfeld, Helena M Earl, Evis Sala, Mercedes Jimenez-Linan, Christine A Parkinson, Florian Markowetz, James D Brenton
Publikováno v:
PLoS Medicine, Vol 12, Iss 2, p e1001789 (2015)
BackgroundThe major clinical challenge in the treatment of high-grade serous ovarian cancer (HGSOC) is the development of progressive resistance to platinum-based chemotherapy. The objective of this study was to determine whether intra-tumour genetic
Externí odkaz:
https://doaj.org/article/0a04b45ee3a2448488392ea351cd23be
Autor:
Corine M Beaufort, Jean C A Helmijr, Anna M Piskorz, Marlous Hoogstraat, Kirsten Ruigrok-Ritstier, Nicolle Besselink, Muhammed Murtaza, Wilfred F J van IJcken, Anouk A J Heine, Marcel Smid, Marco J Koudijs, James D Brenton, Els M J J Berns, Jozien Helleman
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e103988 (2014)
Epithelial ovarian cancer is a highly heterogeneous disease and remains the most lethal gynaecological malignancy in the Western world. Therapeutic approaches need to account for inter-patient and intra-tumoural heterogeneity and detailed characteriz
Externí odkaz:
https://doaj.org/article/89fef8c147544e4ca580af119453cff1
Autor:
Linda E Kelemen, James D Brenton, Christine Parkinson, Hayley C Whitaker, Anna M Piskorz, Ilona Csizmadi, Paula J Robson
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96542 (2014)
BackgroundSerum concentrations of the tumor-associated folate receptor 1 (FOLR1) protein may be a marker for early cancer detection, yet concentrations have also been detected in cancer-free women. We investigated the conditions associated with circu
Externí odkaz:
https://doaj.org/article/954d4f6ea3f643a8bfcc820be7a0718f
Autor:
Nicola S. Meagher, Phineas Hamilton, Katy Milne, Shelby Thornton, Bronwyn Harris, Ashley Weir, Jennifer Alsop, Christiani Bisinoto, James D. Brenton, Angela Brooks-Wilson, Derek S. Chiu, Kara L. Cushing-Haugen, Sian Fereday, Dale W. Garsed, Simon A. Gayther, Aleksandra Gentry-Maharaj, Blake Gilks, Mercedes Jimenez-Linan, Catherine J. Kennedy, Nhu D. Le, Anna M. Piskorz, Marjorie J. Riggan, Mitul Shah, Naveena Singh, Aline Talhouk, Martin Widschwendter, David D.L. Bowtell, Francisco J. Candido dos Reis, Linda S. Cook, Renée T. Fortner, María J. García, Holly R. Harris, David G. Huntsman, Anthony N. Karnezis, Martin Köbel, Usha Menon, Paul D.P. Pharoah, Jennifer A. Doherty, Michael S. Anglesio, Malcolm C. Pike, Celeste Leigh Pearce, Michael L. Friedlander, Anna DeFazio, Brad H. Nelson, Susan J. Ramus
Publikováno v:
Gynecologic Oncology. 168:23-31
Mucinous ovarian carcinoma (MOC) is a rare histotype of ovarian cancer, with low response rates to standard chemotherapy, and very poor survival for patients diagnosed at advanced stage. There is a limited understanding of the MOC immune landscape, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8232bd6bc8a4de1eb0f10e0e21d4e388
https://doi.org/10.1016/j.ygyno.2022.10.022
https://doi.org/10.1016/j.ygyno.2022.10.022
Autor:
Colucci, Elin Bernson, Oisín Huhn, Veronika Karlsson, Delia Hawkes, Maria Lycke, Valentina Cazzetta, Joanna Mikulak, James Hall, Anna M. Piskorz, Rosalba Portuesi, Domenico Vitobello, Barbara Fiamengo, Gabriele Siesto, Amir Horowitz, Hormas Ghadially, Domenico Mavilio, James D. Brenton, Karin Sundfeldt, Francesco
Publikováno v:
Cancers; Volume 15; Issue 13; Pages: 3362
Women with ovarian cancer have limited therapy options, with immunotherapy being unsatisfactory for a large group of patients. Tumor cells spread from the ovary or the fallopian tube into the abdominal cavity, which is commonly accompanied with massi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::eeea4d3fe41cf3316bef0212dfe4d3b5
Autor:
Lena Morrill Gavarró, Maria Vias, Carolin M Sauer, Deborah A Sanders, Anna M Piskorz, Dominique-Laurent Couturier, Stéphane Ballereau, Bárbara Hernando, Michael P Schneider, James Hall, Filipe Correia-Martins, Florian Markowetz, Geoff Macintyre, James D Brenton
Publikováno v:
eLife. 12
High-grade serous ovarian carcinoma (HGSOC) is the most genomically complex cancer, characterized by ubiquitous TP53 mutation, profound chromosomal instability, and heterogeneity. The mutational processes driving chromosomal instability in HGSOC can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b4af16f2a03ca7ef85212a031a75733
https://doi.org/10.7554/elife.83867
https://doi.org/10.7554/elife.83867