PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance.

Autor: Birgitte Holst, Kenneth L Madsen, Anna M Jansen, Chunyu Jin, Mattias Rickhag, Viktor K Lund, Morten Jensen, Vikram Bhatia, Gunnar Sørensen, Andreas N Madsen, Zhichao Xue, Siri K Møller, David Woldbye, Klaus Qvortrup, Richard Huganir, Dimitrios Stamou, Ole Kjærulff, Ulrik Gether

Publikováno v: PLoS Biology, Vol 11, Iss 4, p e1001542 (2013)

Secretory vesicles in endocrine cells store hormones such as growth hormone (GH) and insulin before their release into the bloodstream. The molecular mechanisms governing budding of immature secretory vesicles from the trans-Golgi network (TGN) and t

Externí odkaz: https://doaj.org/article/1b1e37beba824678913f7f38cf8eb86b

Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis

Autor: Rita C. Andersen, Jan H. Schmidt, Joscha Rombach, Matthew D. Lycas, Nikolaj R. Christensen, Viktor K. Lund, Donnie S. Stapleton, Signe S. Pedersen, Mathias A. Olsen, Mikkel Stoklund, Gith Noes-Holt, Tommas T.E. Nielsen, Mark P. Keller, Anna M. Jansen, Rasmus Herlo, Massimo Pietropaolo, Jens B. Simonsen, Ole Kjærulff, Birgitte Holst, Alan D. Attie, Ulrik Gether, Kenneth L. Madsen

Publikováno v: The Journal of Clinical Investigation, Vol 132, Iss 5 (2022)

Bin/amphiphysin/Rvs (BAR) domains are positively charged crescent-shaped modules that mediate curvature of negatively charged lipid membranes during remodeling processes. The BAR domain proteins PICK1, ICA69, and the arfaptins have recently been demo

Externí odkaz: https://doaj.org/article/283f087eadbe4c509ab194ae13855604

An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1

Autor: Pedro Blecua Carrillo Albornoz, Matthew D. Lycas, Ole Kjaerulff, Kenneth L. Madsen, Ina Ammendrup-Johnsen, George Khelashvili, Niklaus Johner, Anna M. Jansen, Ulrik Gether, Rasmus Herlo, Thomas S. Pedersen, Viktor K. Lund, Rita C. Andersen, Dimitrios Stamou, Simon Erlendsson, Nikolaj R. Christensen, Harel Weinstein, Vikram K. Bhatia, Mikkel Stoklund, Jannik B. Larsen

Publikováno v: Herlo, R, Lund, V K, Lycas, M D, Jansen, A M, Khelashvili, G, Andersen, R C, Bhatia, V, Pedersen, T S, Albornoz, P B C, Johner, N, Ammendrup-Johnsen, I, Christensen, N R, Erlendsson, S, Stoklund, M, Larsen, J B, Weinstein, H, Kjærulff, O, Stamou, D, Gether, U & Madsen, K L 2018, ' An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1 ', Cell Reports, vol. 23, no. 7, pp. 2056-2069 . https://doi.org/10.1016/j.celrep.2018.04.074

Summary BAR domains are dimeric protein modules that sense, induce, and stabilize lipid membrane curvature. Here, we show that membrane curvature sensing (MCS) directs cellular localization and function of the BAR domain protein PICK1. In PICK1, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30868816cfb6e5f277ae7b4d23b5a6fd
https://curis.ku.dk/ws/files/198646686/An_Amphipathic_Helix_Directs_Cellular_Membrane_Curvature_Sensing_and_Function_of_the_BAR_Domain_Protein_PICK1.pdf

Opening the psychological black box in genetic counseling. The psychological impact of DNA testing is predicted by the counselees' perception, the medical impact by the pathogenic or uninformative BRCA1/2-result

Autor: Christi J. van Asperen, Anne M. Stiggelbout, Jan C. Oosterwijk, Reinoud D. Stoel, Fred H. Menko, Anna M. Jansen, Joel Vos, Aad Tibben, Encarna B. Gomez-Garcia

Publikováno v: Psycho-Oncology. 21:29-42

Background: It has been hypothesized that the Outcomes of DNA testing (O) are better predicted and/or mediated by the counselees' Perception P) than by the actually communicated genetic Information (I). In this study, we aimed at quantifying the effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ab6c8e6ae8618ce332ff2ed98f474ba
https://doi.org/10.1002/pon.1864

The BAR Domain Protein PICK1 Controls Vesicle Number and Size in Adrenal Chromaffin Cells

Autor: Paulo S. Pinheiro, Ulrik Gether, H. de Wit, Bassam Tawfik, Kenneth L. Madsen, Jakob B. Sørensen, Anna M. Jansen, Matthijs Verhage

Publikováno v: Journal of Neuroscience, 34(32), 10688-10700. Society for Neuroscience
Pinheiro, P S, Jansen, A M, de Wit, H, Tawfik, B, Madsen, K L, Verhage, M, Gether, U & Sørensen, J B 2014, ' The BAR Domain Protein PICK1 Controls Vesicle Number and Size in Adrenal Chromaffin Cells ', The Journal of Neuroscience, vol. 34, no. 32, pp. 10688-10700 . https://doi.org/10.1523/JNEUROSCI.5132-13.2014
Pinheiro, P S, Jansen, A M, de Wit, H, Tawfik, B, Madsen, K L, Verhage, M, Gether, U & Sørensen, J B 2014, ' The BAR Domain Protein PICK1 Controls Vesicle Number and Size in Adrenal Chromaffin Cells ', Journal of Neuroscience, vol. 34, no. 32, pp. 10688-10700 . https://doi.org/10.1523/JNEUROSCI.5132-13.2014
The Journal of Neuroscience, 34(32), 10688-10700. Society for Neuroscience

Protein Interacting with C Kinase 1 (PICK1) is a Bin/Amphiphysin/Rvs (BAR) domain protein involved in AMPA receptor trafficking. Here, we identify a selective role for PICK1 in the biogenesis of large, dense core vesicles (LDCVs) in mouse chromaffin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df885819b176769d1bfd8dd97bedb9ff
https://research.vumc.nl/en/publications/e1b961da-3570-47d9-8bf4-4e3d61811380